Lynparza (olaparib) slows progression in men with BRCA2, BRCA1, and ATM gene mutations

[Tall_Allen]

It was an interim analysis, but results were especially good for men with BRCA1/2 and ATM mutations. A similar analysis showed the benefits on BRCA 1/2 of another PARP inhibitor, Zejula (niraparib):

pcnrv.blogspot.com/2019/10/...

[SPEEDYX]

Good news Iam waiting on my gene mapping....important for future therapies!

[immunity1]

Thanks for update. R

[Hurling24]

Why would this parb work for ATM and others like Rucaparib not ?

[Stegosaurus37 in reply to Hurling24]

Good question. I have the ATM mutation and the TRITON II trial did nothing for me except give me the grandmother of all constipation. I would have hated to have to clean up that ER after they finally unclogged it with an enema.

Then I found out that they knew rucaparib wouldn't work against the ATM mutation BEFORE I started the trial. So I'd want to see evidence that it is effective against the ATM mutation before I started olaparib.

[Hurling24]

Ya exactly the same here . Dynorod were on standby to clear the pipes 🤣🤣

[Dalipup]

Hi Tall_Allen, I saw a reply you put on another question, but thought it better to ask you on a different link. My husband did a guardiant 360 blood draw early on in his treatment. it was explained to us that they would look for tumor "floating by in the blood" to get a sample from. they apparently didn't find that tumor floating by so we have nothing from that test to change his treatments, however often on these sites, you list BRCA genes and say you can get a gene test. is that different from the guardiant 360? would the guardiant 360 been able to detect BRCA without a tumor "floating by" or is this a different kind of gene test that does not require a "floating tumor"? it seems if you can do this with just saliva that you wouldn't need the tumor. I'm just wondering since we have no sample type of things to work from, if getting a gene test would help find a more direct path of treatment than simply trying "the next thing on the list". also wondering if this would have shown up in Guardiant 360 test and since it didn't that it isn't there?

thoughts?

[Tall_Allen]

Guardant 360 looks at cell-free DNA in the blood- the detritis of dead cells. Those cells may have been from tumors or from healthy cells. As the tumors change over time, so will what is picked up by the test. It shows the genes expressed by all your cells. So if you have mutated BRCA genes in some of your tumors only, Guardant 360 may find it.

Other genomic tests, like Foundation One, require a tumor biopsy. They tell you about genomic alterations specifically in that tumor. Unlike Guardant 360, it is specific to the biopsied tumor only.

Germline tests, like Color Genome Dx only look at the DNA of healthy cells. So if you have mutated BRCA genes in all the cells of your body, a germline test will pick it up.

pcnrv.blogspot.com/2018/02/...