Why would PSA drop now?

[Pancake_Lefse]

My Jeff had 5 infusions of carboplatin/cabazitaxel. Unfortunately this treatment proved to be ineffective. Scans showed progression and his PSA soared.

His last infusion was on March 9th. Today Jeff had a PSMA PET scan and we meet with his doctor tomorrow to discuss what treatment Jeff will try next.

When Jeff was in between Docetaxel failing and his actively starting Zytiga, his PSA dropped.

Now, Jeff is in between carboplatin/cabazitaxel failing and who knows what’s next and his PSA dropped from 365 to 275.

I’m baffled. Twice now in between treatments, his PSA has dropped. I’m happy for the drop in numbers, but I don’t understand? His PSA consistently went up the entire time he was on chemo.

Why would his PSA drop now? Is this common? It just doesn’t make sense to me.

[treedown]

If I understand it right scans mean more than PSA at this point in Jeff's treatment. Also maybe the dying cells during this last treatment kept the PSA higher. I am speculating base on things I have read on this forum. Others brighter than me will reply soon. I sure hope its a good sign and what they come up with next is the silver bullet to his PC.

[Tall_Allen]

The important thing is what his scans show.

[Javelin18]

Not quite sure what the PSA readings are saying. PCa has many variants at the same time. Some produce lots of PSA, some little PSA. You might think about a biopsy of the metastatic cancer, to see how it has changed over time and with treatment.

This is done as part of research studies, but not as SOC treatment. I'm not sure if it would give your doctor more information to guide treatment, but I think it is worth discussing with him.

[j-o-h-n]

Probably caused by the nice looking woman he's chilling with..........does she have a twin sister (mums the word with my wife).....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 04/02/2022 7:33 PM DST

[Pancake_Lefse in reply to j-o-h-n]

😂😂🤦‍♀️

[cancerfox]

Has Jeff had any genomic testing done? Sometimes it can help determine treatment options.

cancer.gov/types/prostate/h...

PSA readings are useful, but they seem to be difficult to interpret at times, which is obvious from all the discussions on this website, almost tantamount to reading tea leaves. 🤔