Cabozantinib and Keytruda

[JC531]

Update on my dad, he continues on the above combo treatment. His PSA keeps decreasing and his liver tumors keep shrinking. Very hopeful, it’s now been a one year that his liver was invaded by the prostate cancer.

[noirhole]

How did he qualify for keytruda off label?

[JC531 in reply to noirhole]

He is being treated Mt Sinai NYC, by Dr. Oh, his cancer met some genetic markers, the treatment above is experimental and not approved yet by the FDA

[noirhole in reply to JC531]

Thanks!

[Shooter1 in reply to JC531]

Great and thanks. We need more treatments available to us and he is a pioneer exploring new ways to save life...maybe mine.

[lewicki in reply to Shooter1]

Yes !

[WVtwinsmama in reply to JC531]

Do you recall the genetic markers he met?

[JC531 in reply to WVtwinsmama]

CHK 2 gene, we tried Lynparza first didn’t work, then this combo treatment seems to be working

[addicted2cycling in reply to noirhole]

QUALIFY???

Got my Keytruda + Opdivo + Yervoy injection for my 5+5 back in 2015 because wife and I paid for it. Just not FDA approved so call me a Guinea pig.

[Tall_Allen]

When cabozantanib was explored before it failed for an interesting reason - it changed the tumor microenvironment so tumors did not show up on scans. I hope that combining it with Keytruda does the trick.

[tango65]

This is link has a review of several trials of PC and cabozantinib:

urotoday.com/clinical-trial...

[j-o-h-n]

Again. Keytruda is working on my Lung melanoma..............

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 04/08/2021 6:29 PM DST

[Chugach]

Please keep us posted. I’ve been on Keytruda for about 18 months and after a year of undetectable PSA, mine is finally starting to creep up. It’s an amazing drug/ science. I wondering about other combinations due to the wide genetic diversity of my PC