On to Keytruda.....: So, as I had... - Advanced Prostate...

Advanced Prostate Cancer

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On to Keytruda.....

Faith1111 profile image
29 Replies

So, as I had posted before, my brother failed the ARV/110 trial. A great response at first with dropping PSA but then it started to rise so he ended the trial. His MO wanted him to start the PT 112 trial at Dana-Farber the beginning of April. In the meantime she put him on Darolutimide which only saw Psa continue to rise. A second Foundation One report showed a big increase in mutations which was devastating, however has led us to another option. Dr. Beltran thought he may be a good candidate for Keytruda. He had his first infusion last week. With a high mutational burden, some mismatch repair genes, MSH 2,3 and 6, CDK 12 and TP53 we are once again hopeful. 🙏🏻

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Faith1111 profile image
Faith1111
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29 Replies
Yadifan profile image
Yadifan

Hi Faith! Glad to read your update and to see renewed hope for your brother. I've seen several posts on Keytruda here and it seems promising. Hoping for success for him.

Faith1111 profile image
Faith1111 in reply to Yadifan

Thank you so much Yadifan for your support. Hope you are doing well.

Faith1111 profile image
Faith1111

Thank you for your reply Nal. It is because of you that we have Dr. Beltran. It is also because of you we went to Foundation One. My brother has discussed it with Dr. Beltran although not in depth. I will keep your information at hand. Right now we are praying for Keytruda.

Faith1111 profile image
Faith1111

🙏🏻💞

Tall_Allen profile image
Tall_Allen

I think many get the Foundation One report too soon. I'm glad she found some actionable mutations.

Faith1111 profile image
Faith1111 in reply to Tall_Allen

Yes, agree TA. It is amazing how much you learn as you go along. He never would have been considered for Keytruda based on the first report. Now that we’ve waited this long it is proving useful in directing treatment.

Chugach profile image
Chugach in reply to Faith1111

I had the foundation one test early and then again later and only the second test showed I was MSI-h. I’m not sure if it was missed or if it was later acquired

Faith1111 profile image
Faith1111 in reply to Chugach

Bobs came back not MSI high but he has some MMR mutations and a high TMB. Like TA says things are always developing and changing.

Sebara profile image
Sebara

HiI'm on a clinical trial of Xtandi four tablets every day with Keytruda/plecebo infusion every 3 weeks

It's been 6 months lots of side effects mainly fatigue

Faith1111 profile image
Faith1111 in reply to Sebara

Hi Sebara, what trial are you on? I hope you get a great response. I know there can be some side effects. Do you have any of the mutations?

Sebara profile image
Sebara in reply to Faith1111

HiMy clinical trial is KEYNOTE 991

Xtandi plus Keytruda. I am also on Eligard

George71 profile image
George71

Good news Faith, we are praying for Bob. Keep us posted.

Faith1111 profile image
Faith1111 in reply to George71

Thanks George . I will definitely update you

Chugach profile image
Chugach

Hi Faith- Keytruda was my Hail Mary, PSA went from 122 to undetectable and stayed undetectable for over a year. I had pretty much run out of options. I wish your brother the same success. It’s amazing drug

Faith1111 profile image
Faith1111 in reply to Chugach

So wonderful for you!! I believe you are the person my brother spoke to. You have given him so much hope! We hope we have the same amazing results!

Yank66 profile image
Yank66

Having hope is great medicine, too!

Faith1111 profile image
Faith1111 in reply to Yank66

Yes it is!

Hotrod65 profile image
Hotrod65

Faith, high Mutational Burden is what qualified me for Keytruda..50 infusions over 5 yrs and now just 2 maintenance doses a year has me in Complete Durable Clinical Remission NED...Good luck to your brother..reach out if you have questions.

Faith1111 profile image
Faith1111 in reply to Hotrod65

I cannot tell you how much hearing your words mean to me. Thank you so much for sharing your AMAZING story. So much hope for us and others reading that. I know every cancer is different but there are some commonalities with those responding so well to Keytruda. I continue to pray and be thankful that Bob is getting this opportunity. I very well may reach out to you as we go along. Thank you again for responding. Faith.

Hotrod65 profile image
Hotrod65 in reply to Faith1111

Is your brother at Dana Farber?

Faith1111 profile image
Faith1111 in reply to Hotrod65

Yes. He has Dr Beltran

Hotrod65 profile image
Hotrod65 in reply to Faith1111

I'm at Tuft's Cancer Center..Dr. Paul Mathew.. Genitourinary Oncologist with PC specialization..he is my God.

Faith1111 profile image
Faith1111 in reply to Hotrod65

We are so lucky to live in this part of the country. Boston area is loaded with great hospitals. We are about an hour and a half to two hours from there.

Hotrod65 profile image
Hotrod65 in reply to Faith1111

45 min for me depending on time of day, otherwise 1.5 hrs..Gosh been making this trip for going on 7 yrs now..but that is a very good thing!.

j-o-h-n profile image
j-o-h-n

Keytruda is working on my Lung melanoma.... Right On!!!

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 04/12/2021 9:59 PM DST

Faith1111 profile image
Faith1111 in reply to j-o-h-n

That is wonderful. It could be working on your prostate cancer as well. As you go along you may develop mutations that will respond. I don’t care what your doctors say. I’m saying yes!

ellie2211 profile image
ellie2211

Do mutations form after certain treatments?

Hotrod65 profile image
Hotrod65 in reply to ellie2211

Yes, studies are showing what is called "treatment emergent" mutations.

ellie2211 profile image
ellie2211 in reply to Hotrod65

Thank you for the information

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