Hello
First time posting in the forum. My special someone is a fighter. Several rounds of chemo, spot radiation, Zytiga, Xtandi, and three treatments of Lu177 have all since failed. He’s currently only on the Orgovyx.
Innumerable mets on scans, all in the bones. No soft tissue involvement. He has a reputable MO who is saying he is willing to allow him to try Keytruda as a Hail Mary even though he is not MSI high. He does have high percentages of TP53 and BRCA1 alterations in his recent blood biopsy.
His anemia is quite serious now and has had 3 blood transfusions in the past few months. It had been holding on until that final LU177 treatment. Curious about keytrudas effect on the bone marrow as his is obviously already significantly impaired.
A little background on my guy… He is 61, and has made the most of these past few years of sickness. Until the last few months, he had kept active. His declining blood counts have really taken a toll on his energy level and is leading to muscle weakness. He wants to continue this fight and has just no “give up” in his spirit.
We have an appointment in a few weeks with Tanya Dorff at City of Hope for a second opinion… hoping for some other ideas or trial options. Trying to decide whether to start the keytruda now or wait until after the appointment on 8/17 (if he decides to keep the appointment).
Your responses are very much appreciated.