Three clinical trial options after Zytiga fails

[Nettie8200]

Hello, all!

It’s been a few months since I’ve last posted (had a baby in October and my dad’s PCa was stable-ish) but it looks like the most recent scans showed growth. He’s 71, dx’ed nearly 3 years ago, and has already utilized Zoladex, docetaxel, and Zytiga and some targeted radiation. He’s had widespread mets since dx but largely feels pretty well (aside from Covid knocking him on his rear in October).

With Zytiga losing efficacy, we have choices ahead of us: Xofigo, Jevtana, or three different clinical trials. I feel knowledgeable about the risks and benefits of Xofigo and Jevtana but I’ve never seen these trials. Would love some input on them if you’ve got some expertise to lend!!

Option 1: sEphB4-HSA clinicaltrials.gov/ct2/show...

Option 2: Galunisertib (LY2157299) clinicaltrials.gov/ct2/show...

Option 3: ARV-110

clinicaltrials.gov/ct2/show...

Just upon preliminary research, if we go the trial route, I’m thinking ARV-110 might be the way to go.

Thank you sincerely in advance!

Annette

[Tall_Allen]

1. if it helps, VEGF inhibitors haven't been effective against PC2. Many growth factor inhibitors have failed as monotherapies. If they work, it may be only in combination

3. Degrading the androgen receptor may make sense if you have overexpression (likely if you are CR). You can check with a biopsy and IHC for the AR before you try it.

[Nettie8200 in reply to Tall_Allen]

Thank you, Tall Allen. Yes, a blood test is in order for ARV-110. So far, that’s the one I’m in favor of, if we go with a trial. We may just stick with Xofigo or Jevtana.

[Tall_Allen in reply to Nettie8200]

You won't get AR expression from a blood test. It has to be metastatic tumor tissue.

[GP24]

Here is an article about an ARV-110 trial:

urotoday.com/conference-hig...

[tango65]

I would consider the ARV 110 trial. It is not a randomized trial, he will receive the treatment and there are preliminary data showing that it can work in some patients.

hopkinsbio.org/biotechnolog...

[Nettie8200 in reply to tango65]

I think this is our top choice so far, pending information on which mutations are present for dad.

[ellie2211 in reply to Nettie8200]

Have you decided? We're in a similar boat with my dad ...

[HopingForTheBest1]

I am also now researching viable clinical trials for myself. Have you also looked at other BITE trials, like Regeneron, AMG160, etc.?

[Nettie8200 in reply to HopingForTheBest1]

We have not--just assessing the three dad's oncologist (Dr. Maha Hussain at Northwestern) presented.

[MateoBeach]

What worries me about the ARV-110 is that it is not effective for the common and problematic ARV-7 variant. Any additional way to assess for that and address it?

[Nettie8200 in reply to MateoBeach]

Agreed. It seems like bloodwork and biopsy come before entry into the study to determine what mutations are present, which is good to hear.

[ellie2211 in reply to Nettie8200]

Do you know what the negative side effects could be?

[j-o-h-n]

Hello Nettie, Congratulations on the brat..... male or female? Have fun with him and your Dad will too..... You're a great daughter and I guess the brat will be nice too..... Nothing like babies........

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 01/23/2021 7:39 PM EST

[Nettie8200 in reply to j-o-h-n]

Thanks, j-o-h-n! I love my dad so much and want him to be able to see my lil' brat grow up into a big brat.

[j-o-h-n in reply to Nettie8200]

Don't fret, he'll be around to buy him/her a shiny new electric car for his/her college graduation...

Remember, Pca is slow growing.....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 01/26/2021 2:40 PM EST

[Hidden in reply to j-o-h-n]

Now that's comforting...

[j-o-h-n in reply to Hidden]

You'll be around till your 101..... only the good........

**To play this video click on the title of the video on top of the video**

youtube.com/watch?v=ERWREcP...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 01/26/2021 2:52 PM EST

[Hidden in reply to j-o-h-n]

You are my idol and mentor.