Docetaxel/Taxotere. 2nd time in 3 years. It's a no go this time. No benefit after 3 infusions.

[CAMPSOUPS]

A cancer work around making a good treatment plan not workable.

Good news is although PSA kept rising during infusions scans show no new growth but no shrinkage either. Same old diffuse bone mets I have always had. Current PSA at 80.

Brief history PSA 11/2019--1,621. Bone mets diffuse from skull to shins. Lymph nodes throughout torso. Lupron and 6 rounds Docetaxel 2020. Started Zytiga a year later. Zytiga failed about 3 months ago. Started 2nd time with Docetaxel about then ( about 2 months ago).

We shall see what suggestions MO and team have in coming appt. I'm hoping to continue to try SOC treatments in sequence rather than jump on the Pluvitco bandwagon right away but of course the suggestions from my MO will be key to decisions. (Jevtana, Xofigo w/provenge, even Xtandi ? As hopefully the Docetaxel I've just had or if I get Jevtana the chemo's will "resensitize so that Xtandi is viable" after the Zytiga I've ran thru).

Meantime a nice Christmas break from the chemo crashes, some recovery before hitting "IT" again.

Happy Holidays!

Cheers!

[dockam]

Oh dang Bruddah, my series of Taxoteres didn't pan out, and neither did the Cabazitaxel. I kept asking about adding Carboplatin, but was denied. Maybe that will work against your stubborn PCa or resensitize it to become susceptible to Abiraterone

Fight on Brother

Mele Kalikimaka

Randy

[CAMPSOUPS]

Slap er and ride thru it!

[Hidden]

You deserve a break today ! Rest and recover . Yule tide cheers amigo! Stay strong! 🙏💪

[Kaliber in reply to Hidden]

merry Christmas and a great new year Scott , the boss , LuLu and the kids buddy. From myself and the hammer. Love ya guy ❤️❤️❤️

[Hidden in reply to Kaliber]

Hammer down the new year amigo! ❤️🕊🕊🕊

[Kaliber in reply to Hidden]

❤️❤️❤️

[CAMPSOUPS in reply to Hidden]

Muchos gracias Scott. Warm wishes for a cozy holiday for you and your loved ones.

[Hidden in reply to CAMPSOUPS]

To you and yours as well !🙏❤️🎄

[Carlosbach]

Camps, Glad that there is no apparent sign of increased activity. Fingers crossed that the next round of treatment resets your cancer's sensitivity to treatment. Have a happy holiday season and build some reserves for the coming year.

[CAMPSOUPS in reply to Carlosbach]

Thanks much Carlos. Look forward to more of your writings in the coming year. Enjoy the holiday too!

[Tall_Allen]

Lots of good choices for next year after a well-deserved break.

[Tall_Allen in reply to Tall_Allen]

Add to your list, the combination of a PARP inhibitor+Xtandi, maybe after chemo:

prostatecancer.news/2022/06...

[CAMPSOUPS in reply to Tall_Allen]

Much appreciated.

[CAMPSOUPS in reply to Tall_Allen]

That paper is quite interesting. Enzalutamide with a PARPi.

Thus, inhibition of PARP with a PARPi drug and the addition of an antiandrogen may synergize to inhibit AR signaling and prostate cancer growth and survival.

[Finlay66]

Hi You have a similar diagnosis to me. I will watch your progress with interest. Best wishes

[Kaliber]

TA said it well … I echo his positivity. Best wishes for you and the family brother ….from the hammer and I.

🎅🍾💪💪💪❤️❤️❤️

[CAMPSOUPS in reply to Kaliber]

Good to hear that from you AND the hammer brother Kal. You two have a warm holiday on me lol. Yea, I am positive. thanks to TA and the forum I wouldnt have a list like that of alternatives in mind.

[Kaliber in reply to CAMPSOUPS]

😁💪❤️❤️❤️

[EdBacon]

I'm in a similar situation, only with Jevtana. My doctor agreed to give me one more infusion before Pluvicto starts in January, mainly because I complained that things seemed to be getting worse faster since I stopped chemotherapy.

I'm not sure how well Jevtana is working for me, but it seems to at least be slowing down progression and providing some pain relief. I think "working" is kind of a relative thing. "Better than" may be a better way to look at it.

My doctor and I agree that Pluvicto is a better treatment so that's an option for you as well. I might eventually retry chemotherapy although after 11 cycles, I feel like I've kind of had it, especially if it's not doing much.

[CAMPSOUPS in reply to EdBacon]

Thanks yes Pluvitco will be in the mix. Just havent had Xtandi yet and interested. Some chemo in between my Zytiga failure and starting Xtandi was something I was looking at.

I know you were having some pain that the Jevtana would lesson soon after infusion but wear off. Hope your doing ok.

Your mention of "Better than" made me laugh. "All things considered" has kept coming out of my mouth since dx lol.

[EdBacon in reply to CAMPSOUPS]

I did add the Xtandi to my chemotherapy and it seems to have contributed to the pain relief as well stopping my PSA rise, at least temporarily. It feels to me that I left that time where I could say things work or don't work and it seems more muddled now. I'm taking a lot of pills and chemotherapy and the side effects are almost impossible to tell one from another or what's causing what. I call it "side effect soup". It 's becoming the mix of stuff where I feel like it's just putting the treatment(s) benefits on one side of the scale and all the rest on the other (SE, QOL etc.) and try to see which way it tips. That's where the "better than?" comes from. Sometimes, it doesn't seem like there's necessarily a right or wrong answer although I keep asking the question.