Just wondering if anyone has more informed information/opinions than I do about these trials or others ....i don't know what to recommend to my dad....
He has had: taxotere, xtandi, jevtana(with carboplatin added after a few infusions) and we are now looking for other options.
Thank you guys as always 🤍
Written by
ellie2211
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ARV-110 is a more straightforward trial of a single promising therapy and seems well designed to do this. In particular it is looking for benefit in blocking or degrading androgen receptors that may have become resistant to enzalutamide.ARC-6 appears to be a multi-armed shotgun approach where the results may be interesting for planning future studies but does not seem so definitive. If it were me I’d prefer to participate in the ARV-110 for this reason.
Background:
Proteolysis Targeting Chimera (PROTAC) protein degraders induce selective degradation of targeted proteins by engaging the ubiquitin proteasome system. ARV-110 is an orally bioavailable PROTAC that specifically degrades AR ≥ 95% and achieves anti-tumor activity in ENZ-naïve and -resistant prostate cancer xenograft models.
Methods:
To define the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of ARV-110, pts with ≥ 2 prior therapies for mCRPC, including ENZ and/or ABI, received ARV-110 orally once daily. Dose escalation is per 3+3 design. Endpoints include dose limiting toxicities (DLTs), adverse events (AEs
I am at northwestern medical. zytiga and docetaxel had both stopped working for me. I also had the opportunity for both of the trials you listed.
I tried to get into the AVR-110. I took all the tests and qualified but the trial closed out before I could start.
I decided to do the ARC-6 trial.
I have completed 2 cycles. I have had mild fatigue and some muscle ache but nothing else.
I get scans after the 3rd cycle and we will see how it’s working but after the first cycle my psa dropped from 59.8 to 27.2. I am optimistic and looking forward to continuing.
There are 5 arms for this trial: this is my arm.
I take a daily oral drug (etrumadenant) and every 2 weeks I get 2 infusions zimberelimab, and AB680.
It’s pretty intense with ekg’s before and after the infusions and lots of blood draws. They take vitals every 20 minutes. The treatments last 7 to 8 hours.
Northwestern has a special building just for clinical trials. My wife gets to stay in the room with me and all the nurses are so awesome.
I was in two clinical trails which both failed for me. The first was with LAE001 and afuresertib. The last one was ARV-110. The 1st month of the ARV-110 dropped my PSA by 102 points. At 6 weeks it rose by 44 points and continue to rise. Then my bone scans showed bone mets on my pelvic and spine for the first time. So I recently left the study and decide to pursue LU177 therapy and I received my first treatment 3 weeks ago. Of all the meds that I have taken including xstandi, ARV110 was the worst for me. I was often nauseated and I started losing my hair. I’m glad I’m off of it.
I participated in the ARV-110 trial at Weill Cornell 4 months ago as one of their first patients. After 8 weeks on the trial, I was taken off as my PSA accelerated. It didn't work for me.
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Estrogen Patch ADT
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Trial on the definitive treatment
