What do you all think of the ARC-6 trial and the ARV-110 trials? Help

[ellie2211]

Hi everyone-

My dad has failed chemo (jevtana+carbo) after 6 infusions

His MO at UCLA has mentioned both of these trials:

ARC-6:

clinicaltrials.gov/ct2/show...

ARV-110:

clinicaltrials.gov/ct2/show...

Just wondering if anyone has more informed information/opinions than I do about these trials or others ....i don't know what to recommend to my dad....

He has had: taxotere, xtandi, jevtana(with carboplatin added after a few infusions) and we are now looking for other options.

Thank you guys as always 🤍

[Tall_Allen]

Both good choices.

[MateoBeach]

ARV-110 is a more straightforward trial of a single promising therapy and seems well designed to do this. In particular it is looking for benefit in blocking or degrading androgen receptors that may have become resistant to enzalutamide.ARC-6 appears to be a multi-armed shotgun approach where the results may be interesting for planning future studies but does not seem so definitive. If it were me I’d prefer to participate in the ARV-110 for this reason.

Background:

Proteolysis Targeting Chimera (PROTAC) protein degraders induce selective degradation of targeted proteins by engaging the ubiquitin proteasome system. ARV-110 is an orally bioavailable PROTAC that specifically degrades AR ≥ 95% and achieves anti-tumor activity in ENZ-naïve and -resistant prostate cancer xenograft models.

Methods:

To define the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of ARV-110, pts with ≥ 2 prior therapies for mCRPC, including ENZ and/or ABI, received ARV-110 orally once daily. Dose escalation is per 3+3 design. Endpoints include dose limiting toxicities (DLTs), adverse events (AEs

[ellie2211 in reply to MateoBeach]

Thank you for this breakdown 🙂

[LBD3]

I am at northwestern medical. zytiga and docetaxel had both stopped working for me. I also had the opportunity for both of the trials you listed.

I tried to get into the AVR-110. I took all the tests and qualified but the trial closed out before I could start.

I decided to do the ARC-6 trial.

I have completed 2 cycles. I have had mild fatigue and some muscle ache but nothing else.

I get scans after the 3rd cycle and we will see how it’s working but after the first cycle my psa dropped from 59.8 to 27.2. I am optimistic and looking forward to continuing.

There are 5 arms for this trial: this is my arm.

I take a daily oral drug (etrumadenant) and every 2 weeks I get 2 infusions zimberelimab, and AB680.

It’s pretty intense with ekg’s before and after the infusions and lots of blood draws. They take vitals every 20 minutes. The treatments last 7 to 8 hours.

Northwestern has a special building just for clinical trials. My wife gets to stay in the room with me and all the nurses are so awesome.

So far it’s been a good experience

I have been posting me progress

I will post again after the next treatment

[ellie2211 in reply to LBD3]

Thank you for sharing your experience and updates🙏 i hope it shows good results

[Cosmo3 in reply to ellie2211]

I was in two clinical trails which both failed for me. The first was with LAE001 and afuresertib. The last one was ARV-110. The 1st month of the ARV-110 dropped my PSA by 102 points. At 6 weeks it rose by 44 points and continue to rise. Then my bone scans showed bone mets on my pelvic and spine for the first time. So I recently left the study and decide to pursue LU177 therapy and I received my first treatment 3 weeks ago. Of all the meds that I have taken including xstandi, ARV110 was the worst for me. I was often nauseated and I started losing my hair. I’m glad I’m off of it.

[HopingForTheBest1]

I participated in the ARV-110 trial at Weill Cornell 4 months ago as one of their first patients. After 8 weeks on the trial, I was taken off as my PSA accelerated. It didn't work for me.

[j-o-h-n]

Hello ellie, How old is your dear Dad? (p.s. you're a saint).....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 09/17/2021 5:18 PM DST

[ellie2211 in reply to j-o-h-n]

Hi j-o-h-n, he is 71 years old. He's a great dad/human. 🙂

[j-o-h-n in reply to ellie2211]

Well he must be..... cause you're such a great daughter/human 🙂

The apple doesn't fall..............

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 09/19/2021 12:02 AM DST

[ellie2211 in reply to j-o-h-n]

Thank you ❣️ glad you're back!

[ck722]

Does anybody else know what AN/ ARC5 is?

[j-o-h-n in reply to ck722]

FYI as per Wiki:

The AN/ARC-5 Command Radio Set is a series of radio receivers, transmitters, and accessories carried aboard U.S. Navy aircraft during World War II and for some years afterward. It is described as "a complete multi-channel radio transmitting and receiving set providing communication and navigation facilities for aircraft.

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 09/18/2021 11:59 PM DST

[kreg001 in reply to j-o-h-n]

I was trained on ARC5 in 1967 at Millington NAS. Of course they were soon phased out.

[j-o-h-n in reply to kreg001]

Is that a Roger...... over........

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 09/19/2021 1:06 PM DST