Entering Clinical Trials: My recent... - Advanced Prostate...

Advanced Prostate Cancer

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Entering Clinical Trials

Cleodman profile image
12 Replies

My recent biopsy shows no evidence of a new BRAC1/2 mutation so the PARB inhibitors are not an option for me as a new castration resistant metastatic prostate cancer patient.

Made the decision to remain in Phoenix to enter a clinical trial with the Mayo Clinic this month. They were kind enough to hold off closing phase 1 for one more patient. Myself. So 2 days of infusions every 2 weeks until it does not work anymore or I can’t tolerate the side effects. A new drug called PT-112 paired with immunotherapy agent avelumab. Hopefully this study will broaden our armory in the future.

12 Replies
sszyszkiewicz profile image
sszyszkiewicz

Thank you sir. Thank you.

Magnus1964 profile image
Magnus1964

Good luck. Hope this works for you.

Tall_Allen profile image
Tall_Allen

Thanks for participating. As you probably know, carboplatin+cabazitaxel was more effective than cabazitaxel alone in a recent Phase 2 clinical trial, so there is hope for some novel platins, expecially when combined with an immune checkpoint inhibitor. They seem to be expanding soon to Phase 2 trials:

clinicaltrials.gov/ct2/show...

Cleodman profile image
Cleodman in reply to Tall_Allen

That’s the trial I am doing. Still phase 1 as it is still on dose escalation

Cleodman profile image
Cleodman in reply to Cleodman

Except it is not carboplatin. It’s a novel platin from my understanding.

Peterd110 profile image
Peterd110

Thank you! Please keep us updated with your progress

tdelpozz profile image
tdelpozz

Thank you and hope this is very successful!

j-o-h-n profile image
j-o-h-n

Give em hell........... And if it works I'll treat you to chocolate chip ice cream (two scoops)..

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 07/09/2020 6:10 PM DST

Faith1111 profile image
Faith1111

Praying for your success!

Zolababs profile image
Zolababs

🙏🙏🙏 Give that cancer hell!

TeleGuy profile image
TeleGuy

I am so relieved to hear the news! I have to admit that I've been in the "bargaining" phase regarding your story, hoping that there would be something else you could try. Wishing that we had a better compassionate use law here that would allow lower doses of 177Lu to avoid the pain you went through. But this is good news and I wish you the best and thank you for exploring the roads not yet taken by most of us.

TeleGuy profile image
TeleGuy in reply to TeleGuy

Oh whoops, this was part of your story from 8 months ago that popped to the top again.

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