Prostate cancer breakthrough using ex... - Advanced Prostate...

Advanced Prostate Cancer

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Prostate cancer breakthrough using existing drugs offers hope for patients with world-first trial

George71 profile image
6 Replies

"We made this discovery that adding this second drug, the anti-fungal antibiotic really interfered with the cells ability to process a lot of its waste and as a result we can see under the microscope sometimes these cells explode with debris," he said.

"They're affordable, less than $10 a day," he said.

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Each of the drugs by itself showed cancer killing abilities.

One of the drugs itraconazole (an antifungal drug) - without lowering testosterone in a test by itself (not in combination with hydroxychloroquine the other drug in the study)

" Among the 19 evaluable pts, 9 pts (47%) experienced a PSA decline (mean decline 25.0 %, range 2 – 60 %) by week 12, including one patient (5%) with > 50% PSA decline. Among the 10 pts without a PSA decline, the mean on-treatment vs. pre-treatment PSADT was numerically longer (13.2 vs. 4.8 months, p = 0.17)"

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The second drug in the study hydroxychloroquine is used to treat malaria, rheumatoid arthritis, some symptoms of lupus.

When tested alone it had the following results:

"Results: 64 patients (36 cohort 1; 28 patients cohort 2) with median age 71(55-94) and baseline PSA was 3.25ng/ml (0.24- 45.69ng/ml) were enrolled in the study. 39 patients completed 6 months of hydroxychloroquine therapy and 44 patients completed 5 months of treatment. Out of 64 patients, 52 had at least 5 PSA measurements after the start of treatment, and we restrict our analysis to these patients. In 33 patients of these 52 (63%), the doubling time decreased after treatment began. In 12 of these 52 (23%), the “doubling time” turned negative, consistent with decreasing PSA value."

This new test is combining them both.

9news.com.au/national/new-d...

ascopubs.org/doi/abs/10.120...

ascopubs.org/doi/abs/10.120...

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George71
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NPfisherman profile image
NPfisherman

Thanks for posting, George....in Clinical trials in Australia--some call it Oz...Itraconazole and hydroxychloroquine... it is on that next level treatment level with the dog wormer med....

More interested in the laser treatment for CTC's....sent them a message regarding volunteering for the clinical trial.... we'll see....

Fish

George71 profile image
George71 in reply toNPfisherman

Yes, the laser treatment will work for everyone on all types of cancers.

longleaf profile image
longleaf in reply toNPfisherman

What is the laser treatment.

George71 profile image
George71 in reply tolongleaf

NPfisherman posted about it last week. Here is the link to the article.

spectrum.ieee.org/the-human...

NPfisherman profile image
NPfisherman in reply toGeorge71

Actually, It was Henukit I believe who posted on it....it is strange that some posts get so much attention and some so few.....I did find another new device but wiping out 96% of CTC in 8 hours....wow.....all I can say is hook me up....

Fish

longleaf profile image
longleaf in reply toGeorge71

Thank you. Very informative.

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