Rapamycin (aka Sirolimus) is a very interesting drug of diverse effects. It is being explored in early trials for PC because of positive effects demonstrated in cell cultures of PC cell lines and in animal model (mice). A phase I dosing study in human PC patients demonstrated a safe profile in moderate doses (up to 3.5 mg per week).
There is much interest in Rapamycin for promoting "health-span" in aging and age related diseases. So many of which intersect with our APC population including myself. So I am considering adding a weekly dose to my regimen on an intermittent basis. The following "Opinion" article covers the considerations well with special focus on actual risks and "the fear of rapamycin".
This will not be applicable for many here who are on various intense regimens to control their APC. And I am certainly not recommending it. Just considering it for my own (for now) stable and indolent case. I post this to invite perspectives and thoughts from this community. Thank you. -Paul
Lots of references linked in the above article. Also see: