ARASENS Darolutamide vs Placebo - Advanced Prostate...

Advanced Prostate Cancer

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ARASENS Darolutamide vs Placebo

janebob99 profile image
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This Kaplan-Meier plot show the Castration - Resistant Prostate Cancer Free survival probability (%) for two groups: (A) Darolutamide + ADT + Docetaxel, versus (B) Placebo + ADT + Docetaxel, taken at two different times: 2 years and 4 years.

There is a very large increase in survival probability with the Darolutamide group (A) vs Placebo group (B) at both 2 years and at 4 years. The multiplier is about a factor of 2 better for Darolutamide + ADT + Docetaxe, compared to Placebo + ADT + Docetaxel.

The Cohort was High Risk men.

ascopubs.org/doi/10.1200/JC...

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Maxone73 profile image
Maxone73

from the top of my head ( not going to check one of my old posts right now) the latest ARASENS update talked about progression free survival median not reached (so more than 50% of patients were still free of progression) at 43.7 months. And so was the time to castration resistance median. And from the graphics in the article you posted, even after 57 months median was not reached. Very good news!

janebob99 profile image
janebob99 in reply toMaxone73

Thanks !

It would be interesting if someone compared Darolutamide alone to Darolutamide + Lupron, like they did with enzalutamide. I would expect similar results, since both are anti-androgen drugs.

Maxone73 profile image
Maxone73 in reply tojanebob99

well if you like, they did a triplet comparison with abiraterone

sciencedirect.com/science/a...

ARASENS still perform better

janebob99 profile image
janebob99 in reply toMaxone73

99% reduction in PSA is an excellent response!

Thanks for the article.

Maxone73 profile image
Maxone73 in reply tojanebob99

There you go: ARAMON and ARASTEP, I knew there was something

urotoday.com/video-lectures...

janebob99 profile image
janebob99 in reply toMaxone73

Very exciting! Thanks for the link.

I'm very interested in the darolutamide monotherapy trial.

kainasar profile image
kainasar

Problem is - this data shows efficacy in use for HSPC or mHSPC not for mCPRC or nmCPRC.

street-air profile image
street-air in reply tokainasar

why is that a problem?

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