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Inositol hexaphosphate plus inositol

New paper below.

I don't like anecdotal info, even from the Mayo Clinic, & particularly for a different cancer, but I know that Dr Shamsuddin's formula is popular with many men with PCa.

But please don't try it as monotherapy like this crazy person:

"Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melanoma. Vitamin B inositol is a precursor of IP6 and another naturally occurring compound with anticancer properties. We present a case report of a patient with metastatic melanoma who declined traditional therapy and opted to try over the counter supplement IP6+inositol instead. To our surprise, the patient achieved a complete remission and remains in remission 3 years later. On the basis of this case and previous preclinical studies, we believe further research is indicated in exploring antiproliferative and potential immune stimulating effects of IP6+inositol in patients with metastatic melanoma."

-Patrick

ncbi.nlm.nih.gov/pubmed/306...

Melanoma Res. 2019 Jan 5. doi: 10.1097/CMR.0000000000000577. [Epub ahead of print]

Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma: a case report.

Khurana S1, Baldeo C, Joseph RW.

Author information

Abstract

Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melanoma. Vitamin B inositol is a precursor of IP6 and another naturally occurring compound with anticancer properties. We present a case report of a patient with metastatic melanoma who declined traditional therapy and opted to try over the counter supplement IP6+inositol instead. To our surprise, the patient achieved a complete remission and remains in remission 3 years later. On the basis of this case and previous preclinical studies, we believe further research is indicated in exploring antiproliferative and potential immune stimulating effects of IP6+inositol in patients with metastatic melanoma.

PMID: 30615010 DOI: 10.1097/CMR.0000000000000577

30 Replies
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I took it for a while. Think I read about it on Life Extension. Didn't feel like it did anything for me but its hard to tell and we are all different with different cell line at different stages.

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Hmm Looks like it is readily available:

amazon.com/Swanson-IP-6-Ino...

lifeextension.com/Vitamins-...

lifeextension.com/Vitamins-...

From Live Extension:

Research reported on November 5, 2007 at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine indicates that inositol as well as inositol hexaphosphate (IP6) helps protect the body’s genetic material from the damaging effects of ultraviolet B (UVB) and other radiation. University of Maryland School of Medicine professor of pathology Abulkalam M. Shamsuddin, MD reported that these antioxidant nutrients protect the cells’ DNA from radiation-generated free radicals.

Found in the muscles, inositol has been found to be essential for calcium and insulin metabolism. Recent research indicates inositol is beneficial for stabilizing moods.

Inositol has been found to be essential for calcium and insulin signal transduction, and serotonin activity modulation.1,2 Research indicates inositol is beneficial for stabilizing moods.3-10

Inositol hexaphosphate (IP6), also known as myoinositol hexaphosphate and phytic acid, is a phytochemical found in cereals, soy, legumes, and other fiber-rich foods.1 IP6 is found in most human cells, in which it assists in the regulation of cellular functions.2

Benefits at a Glance:

Acts as an antioxidant

Supports healthy cell division3

Supports healthy platelet activity4

May help supports healthy lipid levels already in the normal range5

IP6 is best consumed on an empty stomach.

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Seems like you might not want to use Inositol hexaphosphate (IP6) ahead of, during or for a period after undergoing radiation therapy.

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Patrick

Do you know what is the difference between

(a) Inositol hexaphosphate (IP6)

lifeextension.com/Vitamins-...

and

(b) Inositol

lifeextension.com/Vitamins-...

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Inositol hexaphosphate (IP6) is a phosphate ester of inositol.

But you may be wondering why both? For that you need to browse through the 39 papers of Shamsuddin:

ncbi.nlm.nih.gov/pubmed/?te...

-Patrick

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Dr. Shamsuddin tells us,

'IP6 (or InsP6) is a 6-carbon-ring carbohydrate (inositol) with 6 phosphate groups that are naturally saturated with Ca++ and Mg++. It was discovered in seeds in 1855-1856 by Hartig; because of its plant origin it was called 'phytin' and in 1910 its molecular structure as myo-inositol-1,2,3,4,5,6-hexakis dihydrogen phosphate was elucidated.'

Inositol lacks the 6 phosphate groups (dephosphorylated IP6).

"The B-vitamin inositol and its derivative IP6 (inositol hexaphosphate) are ubiquitous in soil, plant seeds such as rice, corn, soy, wheat, sesame; and in all mammalian cells. IP6 + Inositol act as broad-spectrum anti-cancer cocktail, boosts immune system, help lower cholesterol, prevent kidney stones and the complications of diabetes, and reduce the risk of cardiovascular diseases, including heart attack, stroke etc. "

The above quotes are from Dr. Shamsuddin's website:

ip-6.net

His book provides a depth of discussion not available at the website:

amazon.com/IP6-Inositol-Nat...

Dr. Shamsuddin is a professor of pathology at the Univ. of MD Medical School and has been there since the 1980's.

PLEASE EVERYONE UNDERSTAND THAT IP6 IS DOSE-DEPENDENT. If you are not getting the results you expected boost your dose 50%. Measure again in 90 days and if necessary boost the dose once again. One dose size does not work for every patient and every type of cancer cell.

Please don't use any OTC product that fails to include inositol mixed with inositol hexaphosphate (Dr. Shamsuddin's talks about this as he discusses the history of IP6 experimentation.) I use Enzymatic Therapy's Cell Forte powder. I have also used IP6 Gold powder (the capsules are too much of a hassle given the mega-dosing prostate cancer demands). There is a third brand which is good but pricey. Message me if you would like more detail on how to take IP6. I have been using it successfully for 3 years. I was diagnosed (G 8) in 2012. Lupron is my only treatment, though I was on Casodex as well in the first 3 years. I DO NOT ENDORSE ANY TYPE OF MONOTHERAPY OR ALTERNATIVE MEDICINE STRATEGY USING IP6. I view it as complementary medicine.

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"PLEASE EVERYONE UNDERSTAND THAT IP6 IS DOSE-DEPENDENT. If you are not getting the results you expected boost your dose 50%. Measure again in 90 days and if necessary boost the dose once again. "

1 How can you know if it is or is not working.

2 with out FDA styled clinical how is it possible to understand proper dosing? Or to even know how dose dependant it is.

3. Where does this "it's highly dose dependant" derive from? Did someone just make it up without hard data?

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My dosing judgments came from PSA testing in 2015 and 2016. The "dose dependent" description comes from Dr. Shamsuddin and his years of experience experimenting with IP6. Read the book. If you don't like it, don't use it.

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Calbear

These are questions you should be asking yourself. Not getting defensive about.

"PSA testing in 2015 and 2016" what psa testing?

"Read the book" that is the response most frequently associated with conspiracy theorists. It is. Really. Faith is not a substitute for evidence.

Books = no peer review from someone on a mission

Hmmm this was looking interesting, but if it is attracting faith based self treating patients, that would be an indicator to me to hold off until there is more evidence.

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I've been taking one or two scoops of this product daily but I'm concerned about the high amount of phosphorus in it. One scoop has 760 mg and mega dosing may stress the kidneys. Other brands don't seem to include it.

amazon.com/Enzymatic-Therap...

ncbi.nlm.nih.gov/pmc/articl...

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Every six months my PCP checks on my kidneys, etc with a comprehensive assessment. I have not encountered any problems with Enzymatic Therapy's Cell Forte or IP6 Gold + Inositol. Your dose seems too light. I found 3 scoops twice a day was too light. I settled on 6 scoops twice a day. No side effects except gas and more trips to the bathroom.

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And it's possible that your kidneys are in great shape. I'm just throwing this out there in case someone with compromised kidney functions decides to binge on this particular product. When I finish the two canisters that I had purchased, I'm going to go back to my regular product that I take daily, which doesn't include large amounts of phosphorus.

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I bought the pills from Cell Forte. How many of those would you think might be a good daily amount? I just started off with one a day to make sure I didn't have negative side effects.

thanks,

George

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George I have little experience with capsules, therefore, I would go with the manufacturer's suggested 5 capsules in the AM and 5 in the PM. When the supply is gone I would purchase the powder which enables larger doses without an extended pill-popping experience. There are numerous people posting on this site using a variety of doses. Dr. Shamsuddin's book emphasizes IP6 is dose-dependent and therefore you must choose a dose that seems to work for you. I tried 6 scoops in two divided doses. That was not sufficient. I found 12 scoops daily in two divided doses is effective. Herman_PSA on this site has settled on 9 scoops daily. The issue is what will it take to move the PSA lower? I should note that my 12 scoops a day is giving me more than 70 grams of medicine daily. Trying to match that with capsules would be an ordeal.

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Thanks Cal. I appreciate it. Have you heard of anyone lowering their PSA due to increasing ip 6?

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Me. But I will first quote from messages in 2018 to me by fellows who have tried IP6:

"Hey CalBear,

Just wanted to let you know I decided to give IP6 and the supplements you suggested another try. I had tried the IP6 prior to my June blood test and it didn't seem to slow the rise in my PSA.

I started in the second week of July...taking 12 scoops of IP6 plus supplementing with the milk thistle and some of the other supplements you suggested. I didn't take the large dosages that you are taking...rather I just took the normal recommended dosages of each...twice daily. I usually just eat two main meals a day.

My July blood test showed a surprising drop in my PSA. My PSA had been doubling each month..starting early this year. My MO dropped Zytiga for me as it seemed to be no longer effective.

I started Radium 223 treatments on June 29, but my MO informed me that it would not likely help with my PSA. I expected my PSA to have doubled once again, but instead it had dropped a bit which was a very nice surprise.

Thank you for the info about the IP6 and supplements!"

A more quantitative message:

"Good Morning CalBear74,

I hope you are feeling well and doing great! Just a quick update. Further great news last week I had my second Lupron shot and a DRE. The doc informed me that "the two nodules on my prostate were gone and the surface was smooth." PSA down to 0.40 from 55 PSA three months ago! IP6 & the Beta Glucan worked well and it should keep me alive in the coming years for sure. Thanks"

The above message is from Herman_PSA who has made this same message public in posts here and at inspire.com.

My story:

I used IP6 powder heavily for 7 weeks as I got started just before my next appointment with PSA feedback in mid-summer 2015. The results my urologist brought in was a number lower (0.1) than he anticipated (at least 0.5) and caused him to ask for a DRE. He could not palpate any nodules and this left him more puzzled. I should add that the pelvic bone ache from two mets I had been experiencing stopped. I left the doctor's office with him looking very upset. I had not told him about the iP6 because he was scornful of supplements when I asked during the communicating about my biopsy.

Herman_PSA had a similar experience as you can read above. Like Herman, I still have my prostate because I am metastatic and my first urologist in AZ said surgery was futile with systemic PCa.

Hope this give you some perspective.

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Thanks for the info. I appreciate it. Does it raise your cholesterol or triglycerides?

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My chol level has been consistently very good for more than 20 years because a friend pushed me to get started on red yeast rice, the molecular model years ago for Lovastatin. My LDL stays in the mid 70's. My friend was the medical director of a medical software company we worked for. He said in his 25+ years of being an ER doc and a FP physician, he never saw a patient have a heart attack whose LDL level was below 100. He said support for this can be found in the Framingham Heart Study.

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That's good news. My LDL has been below 100 since I went to a very healthy diet when I found out about my cancer and coronary disease back in 2015. I worry additional because of the lupron effects but the cardiologist thinks I'm doing fine with diet, exercise and Crestor and baby aspirin. I'll have to look into the red rice yeast for interactions.

Thanks

George

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Patrick you are a champ. Thank you for your many posts. They make healthunlocked a much better site.

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Does IP6 go good with Viennoiseries? (Inside joke folks)

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 01/09/2019 2:44 PM EST

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Sir sprechen nicht treffen! Ich bin anfällig für Gebäck und können die Kontrolle verlieren.

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Κύριε, μην μιλήσετε! Είμαι επιρρεπής σε αρτοσκευάσματα και μπορεί να χάσω τον έλεγχο.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 01/09/2019 8:02 PM EST

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Τα ζυμαρικά δεν βελτιώνουν τη χημεία του αίματός σας. Αρνούμαι να τα φάω όταν υπάρχει πιο υγιεινό φαγητό.

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Thank Goodness, There's someone else here that speaks Greek....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 01/10/2019 11:45 AM EST

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It appears that melanoma has the highest rate of spontaneous remission: ncbi.nlm.nih.gov/pubmed/286... ("Spontaneous regression of malignant melanoma - is it based on the interplay between host immune system and melanoma antigens?" Interesting. And I concur with you about Mayo Clinic reporting this case considering the high rate of remission. Phil

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I'm being treated with Keytruda for my stage IV lung melanoma. So far it's working...

BTW your last name means sugar in Greek...

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 01/10/2019 11:48 AM EST

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Hello John, it's very good to hear that the Keytruda is working for the melanoma. My father told me that my last name meant "remembered by God". It can also mean "Jehovah has remembered". Its of biblical origin and a common Spanish or less common Portuguese name. Cheers, Phil

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We need not resort to "spontaneous remission" to explain the remission of melanoma in the Mayo cancer patient. Dr. Shamsuddin cites the research of Schneider et al. (2009) in his text (p. 170) on IP6: "IP6 + Inositol", and the following bibliography provides a number of citations on experimental work with IP6 (aka "phytate") and inositol with melanoma cells.

ncbi.nlm.nih.gov/pubmed/?te...

amazon.com/IP6-Inositol-Nat...

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I credit IP6 with lowering my husband’s triglycerides by 30 points. Of course I can’t prove that’s what did it but his triglycerides have hovered around the mid 150s for two decades and were measured at the beginning of 2018 at 154 and about three months after taking 8 grams of IP6 (Pure Encapsulations) a day his triglycerides were at 120. We are adding a separate capsule of inositol.

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