What is the best way to take IP6 Inositol to ensure it works optimally in the body?
Also, since it touted to have a very positive effect on the immune system, if it can be
taken with other supplements, would those be like medicinal mushrooms and/or
Beta Glucans?
I take Natures Way IP-6 & Inositol before food in the morning & can say I think it does make a difference. The recommended dose is 2 capsules twice day but the 2 before food is enough for me.
Why are you so sure it makes a difference and what difference do you believe it makes?
Schwah
I read the book by Shamsuddin. IP6 and Inositol. Taking it on faith I guess. My PSA leveled off. Was it this stuff or Metformin or MCP or just coincidence? Some things are unknowable.
I can't understant the shamsuddin's book so can you help me if is mentioned about th brain tumors and ip6 +inositol.
Thanks
The information in his book appears to suggest that IP6 works at such a fundamental level that it offers significant therapeutic action against all cancers.
A key piece of data in it is that it boosts the "anti-cancer gene" P53 17-fold, and just this is hugely impressive given that this gene is regarded as the "guardian of the genome."
Look into Apigenin, found in apples and the chamomile flower teas. It is also a major booster of P53.
Re-read his book. He explains the science behind how and why IP6/Inositol works.
It's not "unknowable magic." Biochemistry and Biology are sciences.
Perhaps the combo?
I see my MO in a few weeks & have the PSA reading. To answer your question, I do not know if it does make a difference to the cancer but if the PSA is down or even constant I will keep on with it.I feel better mentally, maybe that it helps with depression?
Like many supplements we take it is helpful to take that one thing & gauge the reaction.
Thanks!
After reading the Wikipedia about inositol I don't see any use related to prostate cancer. The body produces two grams per day. from glucose. It might help with depression and bipolar disorder. Women may benefit for pregnancy. My own feeling is that the body can have subtle reactions to supplements so they might be used occasionally without problems but overdoses could cause unknown effects.
I am as well as most people who have cancer omitting all sugar from their diets. Maybe the support is necessary, does appear the risk benefit ratio places this as safe.
"IP6 Inositol" Is Not Just "Inositol!" Take your time to read the book and you will find out the difference.
I could only find mouse and in vitro studies for prostate cancer. Here's an example:
Effect of inositol hexaphosphate on cancer stem cell pool of prostate tumors
Komal Raina, Anil K Jain, Dileep Kumar, Vijay Mohan, Paul Maroni, Rajesh Agarwal
Cancer Research 78 (13_Supplement), 272-272, 2018
Prostate cancer (PCa) is the most frequently diagnosed invasive malignancy and second leading cause of cancer-associated deaths in the males in the United States. Inositol hexaphosphate (IP6) a nutrient constituting 6.4% (w/w) or even higher levels in most cereals, legumes, nuts, oil seeds and soybean has been shown to protect against growth and progression of PCa in pre-clinical animal models. Our completed studies in a spontaneous transgenic mouse model of PCa (TRAMP) have shown that IP6 feeding suppresses growth and progression of PCa via its ability to alter tumor vascularity and the energy generating metabolic events in the tumor cells. We also employed quantitative high-resolution nuclear magnetic resonance spectroscopy (1H-, 13C- and 31P-NMR) to assess the metabolic profile and energy state of the IP6-treated human PCa PC3 cell line which validated these in vivo findings. Next, we assessed stage-specific efficacy of IP6 feeding on PCa initiation and growth, progression and angiogenesis, and elucidated the molecular events involved in IP6 effects during these stages. Different groups of male TRAMP mice starting at 4, 12, 20 and 30 weeks of age were fed with regular drinking water or 2% IP6 in regular drinking water for 8-10 weeks. Study end point assessments showed that IP6 treatment results in arrest of tumor grade at earlier stages and prevents its progression to more advanced forms of the disease. In more recent studies, to determine whether these protective effects are mediated via the effect of IP6 on expansion of cancer stem cells (CSCs) pool; we next assessed whether IP6 had the potential to affect the CSC pool in TRAMP prostate tumors. We observed that the anti-PCa effects of IP6 are associated with its potential to eradicate PCa CSC pool, which is recognized to be involved in the initiation, progression, relapse, and therapy-resistance of PCa. IP6 feeding also showed inhibitory effects on the CSC associated transcription factors and signaling pathways. Next, we performed in vitro sphere cluster assays to determine IP6 effect on the self-renewal capacity of the CSCs of PCa cell lines PC3 and HMVP-2. The % of floating spheroids (prostatospheres) generated in the presence of macrophage U-937 conditioned media (with and without IP6 pre-treatment) after 1-2 weeks were determined. The results indicated an inhibitory effect of IP6 on both number and size (volume) of prostatospheres. Since formation of spheroids under specific in vitro conditions is a measure of stemness, it is evident that IP6 has the potential to target the self-renewal of CSCs in PCa cell lines. Since these mechanistic events eventually result in arrest of tumor grade at neoplastic stages, this protective effect of IP6 against PCa might have clinical implications in controlling the malignancy at an early stage. Together, these findings suggest the practical and translational potential of IP6 treatment in suppressing growth and progression of PCa in humans.
There are many such studies demonstrating the efficacy of natural compounds against cancers. Unfortunately, they never move on to human clinical studies and trials. If they can't be patended because they're natural compounds what drug companies would want to move ahead with them. Further, under tightly controlled experimentation, for one reason or another, a natural compound may be missing something in terms of safety at therapeutic levels, stability in the digestive tract, bioavailability, therapeutic duration in the body, etc., discouraging studies from moving on.
I wish more people better understood that in vitro and mouse studies of compounds in a food do not mean therapeutic levels of that compound can be safely achieved in humans by eating that food.
Exactly. Such a stage of testing is to early to make that translation.
There has been clinical use for other cancers eg. With some success. But big pharma are not interested in having a clinical trial. No more money in it for them.
Tantivejkul, K.; Vucenik, I.; Eiseman, J.; Shamsuddin, A.M. Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer. Breast Cancer Res. Treat. 2003, 79, 301–312. [Google Scholar] [CrossRef]
Druzijanic, N.; Juricic, J.; Perko, Z.; Kraljevic, D. IP-6 & Inositol: Adjuvant to chemotherapy of colon cancer. A pilot clinical trial. Rev. Oncol. 2002, 4, 480. [Google Scholar]
Družijanić, N.; Juričić, J.; Perko, Z.; Kraljević, D. IP6 + Inositol as adjuvant to chemotherapy of colon cancer: Our clinical experience. Anticancer Res. 2004, 24, 3474. [Google Scholar]
Sakamoto, K. Long-term survival of a patient with advanced non-small cell lung cancer treated with Inositol Hexaphosphate (IP6) plus Inositol treatment combined with chemo-radiotherapy. Report of case. Anticancer Res. 2004, 24, 3618. [Google Scholar]
Lam, S.; McWilliams, A.; LeRiche, J.; MacAulay, C.; Wattenberg, L.; Szabo, E. A phase I study of myo-inositol for lung cancer chemoprevention. Cancer Epidemiol. Biomarkers Prev. 2006, 15, 1526–1531. [Google Scholar] [CrossRef] [PubMed][Green Version]
Correct, Big Pharma is in business for business!
Graham49, I concur. If these natural compounds can't be patented and marketed in ways to rake in big cash, they just "sit on the bench."
And I believe that this causes people to have a skewed view of them, that they have little efficacy. From my research, it looks like China, India, and Japan do far more research into natural plant compounds to move them toward pharmaceutical-grade development or levels. For instance, I read that the Chinese have developed close to 70 pharmacologically-active compounds used as drugs from magnolia tree bark and root extracts. Because of the two potent anti-cancer polyphenols-honokiol/magnolol--concentrated in the extract, of course a number of these drugs are used for cancer there.
P53 is a chief tumor-suppresor gene--prevents tumors and their development. Yes, the mutation of it, which prevents it from doing it's job, is a major contributor to prostate cancer. Apigenin, and IP6 according to Shamsuddin, work in multiple ways to thwart the mutations of P53 so that it can do its protective work. Apigenin's therapeutic value doesn't stop here.
It works in numerous molecular and biological pathways to protect cellular health... The little Chamomile flower is loaded with it and it (Apigenin) is also what actually gives Chamomile it's "soothing, sedating, calming" effect.
I purchase a 20:1 extract of Chamomile from Kan Pytochemicals (India) on Ebay. So whereas regular Chamomile tea has 2-3% Apogenin, this extract is super concentrated with it and it comes with a real itsy bitsy spoon to prove it.
I've tried many "mood/mind calming" herbals, but Chamomile is so special because it is not just menatlly/ emotionally soothing--but "soul-soothing" as well.
best to take IP 6 with Inositol on an empty stomach -so last thing at night, first thing in morning and mid afternoon. Allowing 1.5 hrs before and after you take it. Cancer preventative dose is just two pills morning and night but cancer therapy is up to 24 pills a day so 8 pills three times a day. You can get it in powder form with a scoop inside. one scoop equals 8 pills. I had a friend cure his prostate cancer with this but it took about a year to bring PSA dowwn from 2.0 to undetectable.This was after radical pros had failed. I am in same boat so have been on it for 3 months and so far PSA has dropped from .3 to .2-I am delaying radiation another three months to see what happens...
Could you share what has happened....?
Zytiga advise on best time to take. 
IP6 supplementation ok during radiation?
What is my best treatment option?
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