Inositol hexaphosphate plus inositol

New paper below.

I don't like anecdotal info, even from the Mayo Clinic, & particularly for a different cancer, but I know that Dr Shamsuddin's formula is popular with many men with PCa.

But please don't try it as monotherapy like this crazy person:

"Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melanoma. Vitamin B inositol is a precursor of IP6 and another naturally occurring compound with anticancer properties. We present a case report of a patient with metastatic melanoma who declined traditional therapy and opted to try over the counter supplement IP6+inositol instead. To our surprise, the patient achieved a complete remission and remains in remission 3 years later. On the basis of this case and previous preclinical studies, we believe further research is indicated in exploring antiproliferative and potential immune stimulating effects of IP6+inositol in patients with metastatic melanoma."

-Patrick

ncbi.nlm.nih.gov/pubmed/306...

Melanoma Res. 2019 Jan 5. doi: 10.1097/CMR.0000000000000577. [Epub ahead of print]

Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma: a case report.

Khurana S1, Baldeo C, Joseph RW.

Author information

Abstract

Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melanoma. Vitamin B inositol is a precursor of IP6 and another naturally occurring compound with anticancer properties. We present a case report of a patient with metastatic melanoma who declined traditional therapy and opted to try over the counter supplement IP6+inositol instead. To our surprise, the patient achieved a complete remission and remains in remission 3 years later. On the basis of this case and previous preclinical studies, we believe further research is indicated in exploring antiproliferative and potential immune stimulating effects of IP6+inositol in patients with metastatic melanoma.

PMID: 30615010 DOI: 10.1097/CMR.0000000000000577

30 Replies

oldest • newest

cesanon

a month ago

Hmm Looks like it is readily available:

amazon.com/Swanson-IP-6-Ino...

lifeextension.com/Vitamins-...

From Live Extension:

Research reported on November 5, 2007 at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine indicates that inositol as well as inositol hexaphosphate (IP6) helps protect the body’s genetic material from the damaging effects of ultraviolet B (UVB) and other radiation. University of Maryland School of Medicine professor of pathology Abulkalam M. Shamsuddin, MD reported that these antioxidant nutrients protect the cells’ DNA from radiation-generated free radicals.

Found in the muscles, inositol has been found to be essential for calcium and insulin metabolism. Recent research indicates inositol is beneficial for stabilizing moods.

Inositol has been found to be essential for calcium and insulin signal transduction, and serotonin activity modulation.1,2 Research indicates inositol is beneficial for stabilizing moods.3-10

Inositol hexaphosphate (IP6), also known as myoinositol hexaphosphate and phytic acid, is a phytochemical found in cereals, soy, legumes, and other fiber-rich foods.1 IP6 is found in most human cells, in which it assists in the regulation of cellular functions.2

Benefits at a Glance:

Acts as an antioxidant

Supports healthy cell division3

Supports healthy platelet activity4

May help supports healthy lipid levels already in the normal range5

IP6 is best consumed on an empty stomach.

CalBear74

Dr. Shamsuddin tells us,

'IP6 (or InsP6) is a 6-carbon-ring carbohydrate (inositol) with 6 phosphate groups that are naturally saturated with Ca++ and Mg++. It was discovered in seeds in 1855-1856 by Hartig; because of its plant origin it was called 'phytin' and in 1910 its molecular structure as myo-inositol-1,2,3,4,5,6-hexakis dihydrogen phosphate was elucidated.'

Inositol lacks the 6 phosphate groups (dephosphorylated IP6).

"The B-vitamin inositol and its derivative IP6 (inositol hexaphosphate) are ubiquitous in soil, plant seeds such as rice, corn, soy, wheat, sesame; and in all mammalian cells. IP6 + Inositol act as broad-spectrum anti-cancer cocktail, boosts immune system, help lower cholesterol, prevent kidney stones and the complications of diabetes, and reduce the risk of cardiovascular diseases, including heart attack, stroke etc. "

The above quotes are from Dr. Shamsuddin's website:

ip-6.net

His book provides a depth of discussion not available at the website:

amazon.com/IP6-Inositol-Nat...

Dr. Shamsuddin is a professor of pathology at the Univ. of MD Medical School and has been there since the 1980's.

PLEASE EVERYONE UNDERSTAND THAT IP6 IS DOSE-DEPENDENT. If you are not getting the results you expected boost your dose 50%. Measure again in 90 days and if necessary boost the dose once again. One dose size does not work for every patient and every type of cancer cell.

Please don't use any OTC product that fails to include inositol mixed with inositol hexaphosphate (Dr. Shamsuddin's talks about this as he discusses the history of IP6 experimentation.) I use Enzymatic Therapy's Cell Forte powder. I have also used IP6 Gold powder (the capsules are too much of a hassle given the mega-dosing prostate cancer demands). There is a third brand which is good but pricey. Message me if you would like more detail on how to take IP6. I have been using it successfully for 3 years. I was diagnosed (G 8) in 2012. Lupron is my only treatment, though I was on Casodex as well in the first 3 years. I DO NOT ENDORSE ANY TYPE OF MONOTHERAPY OR ALTERNATIVE MEDICINE STRATEGY USING IP6. I view it as complementary medicine.

in reply to GeorgeGlass

21 days ago

George I have little experience with capsules, therefore, I would go with the manufacturer's suggested 5 capsules in the AM and 5 in the PM. When the supply is gone I would purchase the powder which enables larger doses without an extended pill-popping experience. There are numerous people posting on this site using a variety of doses. Dr. Shamsuddin's book emphasizes IP6 is dose-dependent and therefore you must choose a dose that seems to work for you. I tried 6 scoops in two divided doses. That was not sufficient. I found 12 scoops daily in two divided doses is effective. Herman_PSA on this site has settled on 9 scoops daily. The issue is what will it take to move the PSA lower? I should note that my 12 scoops a day is giving me more than 70 grams of medicine daily. Trying to match that with capsules would be an ordeal.

12 days ago

Me. But I will first quote from messages in 2018 to me by fellows who have tried IP6:

"Hey CalBear,

Just wanted to let you know I decided to give IP6 and the supplements you suggested another try. I had tried the IP6 prior to my June blood test and it didn't seem to slow the rise in my PSA.

I started in the second week of July...taking 12 scoops of IP6 plus supplementing with the milk thistle and some of the other supplements you suggested. I didn't take the large dosages that you are taking...rather I just took the normal recommended dosages of each...twice daily. I usually just eat two main meals a day.

My July blood test showed a surprising drop in my PSA. My PSA had been doubling each month..starting early this year. My MO dropped Zytiga for me as it seemed to be no longer effective.

I started Radium 223 treatments on June 29, but my MO informed me that it would not likely help with my PSA. I expected my PSA to have doubled once again, but instead it had dropped a bit which was a very nice surprise.

Thank you for the info about the IP6 and supplements!"

A more quantitative message:

"Good Morning CalBear74,

I hope you are feeling well and doing great! Just a quick update. Further great news last week I had my second Lupron shot and a DRE. The doc informed me that "the two nodules on my prostate were gone and the surface was smooth." PSA down to 0.40 from 55 PSA three months ago! IP6 & the Beta Glucan worked well and it should keep me alive in the coming years for sure. Thanks"

The above message is from Herman_PSA who has made this same message public in posts here and at inspire.com.

My story:

I used IP6 powder heavily for 7 weeks as I got started just before my next appointment with PSA feedback in mid-summer 2015. The results my urologist brought in was a number lower (0.1) than he anticipated (at least 0.5) and caused him to ask for a DRE. He could not palpate any nodules and this left him more puzzled. I should add that the pelvic bone ache from two mets I had been experiencing stopped. I left the doctor's office with him looking very upset. I had not told him about the iP6 because he was scornful of supplements when I asked during the communicating about my biopsy.

Herman_PSA had a similar experience as you can read above. Like Herman, I still have my prostate because I am metastatic and my first urologist in AZ said surgery was futile with systemic PCa.

Hope this give you some perspective.