My oncologist believes in aggressive therapy for advanced prostate cancer. My last CTscan showed two or three likely lesions in my pelvis. That, so far, is the extent of my disease progression. I am now receiving quarterly Lupron shots. My second was two weeks ago. I was first treated with radiation therapy in 2005 (see my introductory post). The first Lupron shot brought my PSA to 1.3 from 19--a sudden spike. He is advising that I add Zytiga to my regimen. Is anyone else following a similar plan? My doctor has contacted my insurance for pre-authorization because the cost of the Zytiga pills is in excess of $9,500 per month. What will I gain from this addition? Appreciate any comments as I am a bit bewildered by all the choices.