Recurrent after RP and XRT. One bone met detected with PSMA scan. I had SBRT to the met and have been on Lupron and Casodex for nine months. The numbers are good. T=6 and PSA <0.02. The MO is suggesting adding Zytiga for another six months then stopping to watch the numbers. He feels that intensifying the treatment at this time may be beneficial. There are no evidence-based studies on this, but it seems like a reasonable extrapolation.
I am tolerating the current ADT pretty well and wonder what will happen. Has anyone else added Zytiga to Lupron and Casodex? What kind of additional side effects (if any) did you experience? I'm thinking (hoping!) that since my T is already suppressed, adding the Zytiga may not make much difference in terms of how I feel. Any thoughts?