Anyone here experienced cancer re activation post-Proton radiation treatment? Underwent treatment in 2013. PSA rise began in March 2015. Went 2.4 to 39 by Sept. 2015. Scans showed metasteses to one pelvic lymph node. Began Degarelix in Nov 2015. PSA dropped to .05. And lymph node shrunk 50%. Scans showed no other spots in bones. Also started Cabozantinib in Feb 2016 for clinical trial. PSA began slow rise in June 2016, but doubling every month to 8.4 in Dec 2016. Changed over to Lupron. Doctor wants MRI of Prostate, thinks that is sight of activity. If so will wantvto freeze it, then remove along with pelvic lymph nodes. I am not particularly happy with this course. Having had Radiation to prostate, I'm concerned the surgery will be very difficult and may result in poor recovery with multiple issues. Has anyone undergone this surgery post-Proton Radiation? How did it affect you? I am at MD Anderson for treatment.