Experiences with

Degarelix

Switched from 6-month Lupron depot shots to monthly Degarelix shots. (Degarelix is only available in 1 month shots). Degarelix does NOT give me the brain fog that Lupron used to give. Increased my Lexapro (depression medicine) from 10 mg to 20 mg daily. Exercising 6 days per week, instead of 4.

However they have recommended that Instead of Monthly Dose of Degarelix (Firmagon), I may switch to Lupron 22.5 mg , as a once in three months dose. May I seek your comments on this please. 😀

She seems to be looking at Eligard or Degarelix. Any comments? Other preferences based on fewer side effects balanced with effectiveness?

Prognosed Treatment •Degarelix 80 mg (monthly) •Denosumab 120 mg (monthly) •Abiraterone 1000 mg (Daily) •Prednisone 05 mg ( Daily ) If any one has any suggestions/ comments , to make they are welcome. 😀😀

I've been on ADT for 14 3/4 months. (1st month was Degarelix, then 12 months Lupron, now back to Degarelix). I want to try to reach 24 months of ADT. I know of the Nabid study thanks to Tall (Heroic, Generous, Knowledgeable) Allen, but want to attain 2 years minimum of ADT.

So we have done triple hormone therapy Bicalutamide (which we stopped a few years back) 

Degarelix and Zytiga are also not suppressing a PSA rise now which is currently 61. It has been as high as 433 about 9 years ago. We got several years out of the above.

He is still asymptomatic.



I started Degarelix on Nov 13 and Abiraterone about 3 weeks later. Would probably have started later but traveling forced a slightly different schedule than originally planned. I just got the results of a PSA test done yesterday. It is about 11 compared to the previous one before ADT of about 115.

Question: How long does it take for degarelix to be completely flushed out of the body after just one injection?

I will continue with monthly Degarelix injections. I hope to hear some opinions on the antibodies and agents involved. I will share what I find out. Thanks Philly

It has been suggested to me that I reconsider an orchiectomy (versus first-line ADT) after opting for degarelix, then lupron for the last few years.

Since diagnosis last September have monthly Degarelix injections. Chemo was stopped. Oncologist phoned to say he was happy with PSA and to come back in 3 months. Covid means they don't won't face to face appointments. After the chest infection, I can hardly walk.

Used adjuvant ADT with degarelix plus estradiol patches. Approximately 5-6 months until T levels recovered. Post RT my PSA fell by about half (.25 to .15 and staying there for 3 months now).

Recent Egyption study [1] comparing physical castration to Degarelix [Firmagon]. (Degarelix is a GnRH [LHRH] [u]antagonist[/u]. Traditional chemical castration drugs such as Lupron are GnRH receptor agonists.)

He is on Androgen Suppression Therapy, taking Degarelix injections once a month and daily oral medications of abiraterone & prednisone, and PSA levels have come down from 229 to 1.3.

My husband will probably begin ADT but still concerned about cardiovascular issues, specially blood clots. What about estrogen patches or gel, any news?

PSA returned, 3.65, with cessation of ADT, so recommenced degarelix Dec 2015 (I had waited a couple of months while expecting to start Dr. Amato’s trial of apalutamide, which never did start due to his health and eventual death.)

I am getting Degarelix and Xgeva injections. The doctor's office sent me a bill amounting $2600 which is the deductible from Anthem blue cross. I am covered at the same time by Medicare. It seems I have to pay only 20 per cent of the $2600. But they insists I am responsible for the amount.

I received my first Firmagon shots (2) on Monday 10/19/2020. Three days in and the pain is still very much present from the red swollen hard pot belly that resulted. Not sure I can face this monthly for 2-3 years, even if 1 shot going forward. Is the first treatment the worst from the large dose?

Today he got his first shot , Degarelix 240mg , the urologist said we should wait for the result in a month, he said for now , we can’t tell which treatment may come next! I googled the name and I found out it’s a chemotherapy medication, what does it mean to you ?

I was having side effect taking degarelix what with weakness, area swelling, fever but I was tollerating it. Dr. said I could get the three month shot. What one almost killed me. the time release was litterially an ovedose. Went back to the once a month.