Had my third Xofigo injection this week. Xofigo injections are easy and take only about five minutes once a month for six months. So far, little to no side effects. Blood tests have all looked good. PSA down to 1.15 from a high of 9 a few months ago. Testosterone 15.
About 2 weeks after my second injection, I quickly started to get pain relief from severe cancer pain in my spine, ribs and left femur, which had required 2 mg of hydromorphone every 4 hours to keep the pain tolerable. About 3 weeks ago I was able to go off the hydromorphone entirely. Since, I've been able to keep the pain very tolerable with 220 mg naproxen sodium every 8 hours.
I had been on the hydromorphone for about 3 months. Tapering off the hydromorphone by slowly increasing the time between 2 mg doses by two hours per day until I was on one 2 mg dose per day worked pretty well. (I started the naproxen for any cancer pain between doses during this time). When I went off the last 2 mg dose I experienced unpleasant withdrawal symptoms (chills, sweats, stomach pain, restless arms and upper body, and sleeplessness) for 4 or 5 days. While I was on the hydromorphone it tore my stomach up pretty good. (Severe stomach pain for which I had to take a another prescription medication). Since I have gone off the hydromorphone, stomach pain has gone, I feel much better and have started to do some light exercise again.
I resumed Xgeva injections about 2 weeks ago. No noticeable side effects yet.
I hope my experience on Xofigo so far is helpful to anyone contemplating starting it. So far, it seems a good choice for severe cancer pain from multiple bone metastasis.