I just got another Lupron shot on Friday the 9th. The injection site always always is sore for a couple of days, but this time by day three i was having severe pain in known locations for mets. Throchanter, pelvis, sacriliac all had sever pain, but only on the left side. I have mets on the right side in the same locations but have never had any even minor pain. I got strong cold chills shortly before the severe pain kicked in and the severe pain lasted about 10 hours.
I had this exact pain before about 6 weeks ago and that was about 6 weeks after the last Lupron shot. None of this makes sense and my care team doesn't seem that concerned.
Plus, since I started Zytiga on July 1st, the pain is worse now than it ever was on the previous medications, Erlearda first, and only 3 months of Xofigo.
Getting quite frustrated.
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bglendi53
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With my first injection of Eligard, I experienced a huge lump and discomfort at the site for a number of days. I had my second recently and haven't had any side effects. Not sure of the location had any effect but I had her put it closer to my center.
I have been on 3-monthly injections for a year (Zoladex). The nurse alternates the injection site, between left and right side. Always some bruising which goes away after a couple weeks.
pain in known met sites after Lupron inject is nothing I hv experienced? Ask them to go slowly next injection for site pain. When they do it quickly, I get bruised and limp for 3 days. Firmagon should be a 30 second injection.
You mention changing from other ADT’s. Is your PSA dropping again? My common sense tells me you could be experiencing the death or sennescence of PCa cells in those locations but just a guess. Also it has been said many times here that when one ADT drug stops working, others will also stop soon after it seems that 6 doses of Docetaxel, or LU, or BAT, can reinvigorate ADT, if that is the case. Mike
I've been getting Lupron for two years so I really don't think Lupron is the problem. But it is so coincidental that's what make me wonder. But I had this same pain in the exact same area about 6 weeks ago. My CPN MO called me today and when I told her about the pain ( again ) she said I must have pulled something. I laughed right at her.
My PSA dropped once after my first month of Zytiga to 24 from 33, but this past Friday it exploded to 92 only 5-6 weeks after being 24. Now they want to do another PSMA-Pet ( I had one on July 22nd ), but I'm sure the insurance will say NO.
Listen, that info of PSA jumping to 92 from 24 in 5-6 weeks is a whole new IMPORTANT piece of info you had not given. Pain at Met sites, with a PSA Doubling time of approx 2-1/2 weeks is an ADT Failure. YOU MUST TAKE THIS SERIOUSLY. You mentioned other ADT before Lupron & Zytiga (Erleada & Xofigo).
YOUR CARE TEAM SHOULD BE CONCERNED. You may need some form of Chemo (like 6 doses of Docetaxel or another), or you may need SABR/SBRT to known Mets to control pain, but Man, raise your voice with your MO, or URO, until you get noticed. Tell them about your PSA Doubling time. This should not be put on the back burner. This should be dealt with NOW. THIS WEEK.
I got a call from the CNP this afternoon. They want to do new PSMA Pet scans, which i just did on July 22, so I'm sure insurance will say no. If they do, then they want to revert to bone and CT Scans, which iI think is a waste of time.
I told them today I may be seeking another opinion, but what can I do, I'm already going to the Cleveland Clinic
changing Dr’s takes time. May be a month before new Doc can see you. SABR Radiologist will do scans as a matter of practice. If they know you are in PAIN, they will fast track you in.
Not sure if this answers your query. I have received 24 injection quarterly of either Lupron or Eligard. Always in the upper butt (hip). The Eligard stung for 5 seconds and no soreness. The Lupron was sore for about two days; but that finally disappeared after 15 or so. I have never had any second line ADT. I never experienced pain anywhere else. I started with two Mets to my spine, I don’t know your age, but I was 57 when I started. I am 75 today. The only pain that I have is associated with aging and paying for my activities as a young man.....i.e., Arthritis. I would listen to your MO and team as they have experience in this treatment. Best wishes.
After a couple of injections I found a nurse (male) that could administer the Lupron without too much pain. I made sure he was available each time I went in for my 3 month treatment. Hang in there.
My last Lupron shot was January 2021... and the past week I've been having pain at the injection site (it's easy to determine that's where the pain is - it's intra/intermuscular and right in the butt cheek where my last shot was given.)
Go figure - Lupron - the gift that keeps on giving..
My testosterone was 330 or so at my last read.. so the Lupron should be gone. I think it's probably left-over muscle damage from the reservoir the shots create..
BTW - never had any pain when the shot was given except a bit of soreness after. In my case - the urologist gave me the shot, he didn't leave it to a nurse.
I'm starting think that may be the only way for me too. I asked the CNP yesterday why they havent checked my testotorone lately, so far she hasn't responded.
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