My husband was diagnosed Gleason 8 (4+4) aggressive prostate cancer 13 years ago when he was 68 years old. He has had many treatments over the ensuing years, beginning with brachytherapy (radioactive “seed” implants) followed by external beam radiation in Cancer Year (CY) 1.
In CY 3 he began hormonal therapy (Lupron Depot injections). By CY 5, he was diagnosed with HRPC (hormone resistant PC) and metastatic castration resistant prostate cancer (MCRPC).
By CY 7 it was time for chemotherapy for nine months, then chemotherapy was ceased. That same year he was prescribed Zytiga (250mg 4 tabs/day) with Prednisone with monthly injections of Xgeva.
In CY 8 he first experienced pain , primarily in the sacrum region, and is being treated with Hydrocodon-acetaminophin, which gives relief from the pain.
By CY 9 bone scans indicated cancer had spread (distant metastatic focus) to spine, rib, skull, leg and arm bones. External radiation beam therapy on L5, sternum, and T5 caused difficulty in swallowing due to a sore esophagus.
CY 10 he received Provenge therapy, followed by Xtandi.
CY 11 he had IXofigo, intravenous radiation. A bone scan indicated multiple ares of increased uptake (more mets).
CY 12 he began more chemotherapy (Jevtana) followed 24 hours later by an injection of Neulasta and an injection of Procrit when his hemoglobin count has been too low. Megestrol Oral suspension (40mg) has been prescribed for lack of appetite and has been effective. A wheelchair was prescribed and obtained.