ART ADT Metabolic Side Effects
1. Appropriate use: 80% is for T3 T4 undergoing radiation treatment
2. Inappropriate use: 20% for T1 T2 and Gleason 2 through 6
3. Insulin:
• Hormone produced in response to glucose intake
• Largest site of uptake is in the muscles
• Loss of muscle mass leads to insulin resistance
• Reason why exercise prevents insulin resistance
4. SEER analysis 73,196 men
• 44% increase in risk for diabetes
5. ADT n Lipids
• Increasing triglycerides
• Elevated cholesterol
• Increasing LDL and HDL
6. Most men with prostate cancer die of cardiovascular events. SEER
• 16% increase risk for CHD
• 11% increase for MI
• 60% increase in risk for cardiac death
7. 70% of Americans are obese or overweight
8. ADT reduces prostate cancer deaths 31% in meta-analysis of RCTs (random controlled study) with vs without ADT
9. Low carbohydrate diet effects on melancholic syndrome highlighted
• 20 g per day carbohydrate studied
• Effects on HOMA dramatic; The homeostatic model assessment (HOMA) is a method used to quantify insulin resistance and beta-cell function. It was first described under the name HOMA by Matthews et al. in 1985.
10. Exercise effect on ADT side effects;
• Exercise 30 minutes per day five days a week
• Dramatic reduction in weight and fat body mass
• BMC bone mineral content unchanged versus a 2.3% loss in the control arm.
YouTube LINK: youtu.be/YYe0ym5IxKo
Biopsies
Most Recent MRI
