ART AACR Journal ; Effect of Sulforaphane in Men with BCR after Radical Prostatectomy

[RMontana]

I have posted an NIH study with similar findings and have noted that I have taken 20mg of stabilized Sulforaphane for 2 1/2 years now (study was 60mg for M6 or 6 months)...who knows if my dosing is sufficient, but the length of supplementation is far greater. Regardless, I keep taking the supplement and it appears there is solid science behind the claim that the stabilized form of Sulforaphane works against progression of PSA! Be alert that all but one brand of supplement sold is not 'stablized,' and are precursors of Sulforaphane (Glucoraphanin )...I believe that brocholy sprouts will also give you the stabilized version of Sulforaphane directly; it takes some labor to get them to grow, then blending to get them juiced for consumption. See this article.

mara-labs.com/blogs/journal...

The AACR studies primary end point was not met but that was a PSA slope reduction greater than what was achieved, which is by itself significant. Take a look and see if this should be part of your regime...the longer it takes PSA to double the better the outcomes for progression in all aspects. The study does show that the positive effects on reduction of PSA doubling disappears with the end of supplementation and that the placebo group's PSA surge at M6 was higher than the control.

Volume 8, Issue 8, 1 August 2015 (Current)

Because the phytochemical sulforaphane has been studied extensively as an anticancer agent, we performed a double-blinded, randomized, placebo-controlled multicenter trial with sulforaphane in 78 patients (mean age, 69 ± 6 years) with increasing PSA levels after radical prostatectomy. Treatment comprised daily oral administration of 60 mg of a stabilized free sulforaphane for 6 months (M0–M6) followed by 2 months without treatment (M6–M8).

Treatment comprised daily oral administration of 60 mg of a stabilized free sulforaphane for 6 months (M0–M6) followed by 2 months without treatment (M6–M8). The median log PSA slopes were consistently lower in sulforaphane-treated men. Mean changes in PSA levels between M6 and M0 were significantly lower in the sulforaphane group (+0.099 ± 0.341 ng/mL) than in placebo (+0.620 ± 1.417 ng/mL; P = 0.0433). PSA doubling time was 86% longer in the sulforaphane than in the placebo group (28.9 and 15.5 months, respectively). PSA increases >20% at M6 were significantly greater in the placebo group (71.8%) than in the sulforaphane group (44.4%); P = 0.0163. Compliance and tolerance were very good. Sulforaphane effects were prominent after 3 months of intervention (M3–M6). After treatment, PSA slopes from M6 to M8 remained the same in the 2 arms. Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy. Cancer Prev Res; 8(8); 712–9. ©2015 AACR.tje s

aacrjournals.org/cancerprev...

[Ramp7]

Where do you obtain yours from, stabilized Sulforaphane? Friedman has mentioned the benefits of this.

[RMontana in reply to Ramp7]

Here is the only source I can find; Amazon...Rick

BROQ Sulforaphane

[Scout4answers]

Do we know if this is just masking PSA or actually slowing progression?

[RMontana in reply to Scout4answers]

If you read the study it slows PSA doubling. But the dose is 3 times what is recommended in the only supplement I can find that has stabilized Sulforaphane; guess I could just take 3 times the recommended dose and that would run over $150 a month...not bad. Here is the only source for stabilized Sulforaphane I know of is on the market...we could grow our own spouts as well....Rick

BROQ Suforaphane Stabilized Supplement

[Ramp7 in reply to RMontana]

A little pricey.

[RMontana in reply to Ramp7]

...yes, that is why I dont take the 60mg a day; it would triple this cost per month...the suggested long term dose on the bottle is 2 per day, one bottle per month...that is less than we we spend on capucinos...who knows. I have done this for 2 1/2 years now.

[Ramp7]

This is what I been buying.

I have been taking this one.

[RMontana in reply to Ramp7]

Check to see if this is 'stabilized' Sulforphane...from what I understand only BROQ has this...the others are precursors to Sulforphane, like Glucoraphanin. Note that the pills you have are 13% Glucoraphanin and only 0.4% Sulforaphane (does not say its stabilized either)...BROQ claims to be 100% stabilized Sulforaphane at 20mg per dose...

I am not representing this supplement and get nothing from promoting it...I am only following the labeling. My brother makes vitamins for his trade and is a Phd Natural Chemist so I got most of this info from him...BROQ that I know of is the only supplement with 100% stabilized Sulforaphane...Rick

BROQ vs other Supplements w Precursors

[tn12 in reply to RMontana]

Would eating 100g of sprouts per day sufficient?

[RMontana in reply to tn12]

I dont know and I am thinking about buying and growing my own...but take a look at the LINK in the text above; its a site that promotes growing your own sprouts...it appears that if we did that we would get Sulforaphane is high doses; dont know if this is stabilized or not...check this out...Rick

foodnerdinc.com/blogs/food-....

PS 1 cup of sprouts, 'sprouted,' may be a LOT of sprouts...dont have any idea...if someone knows please clarify.

Contentes of 91 Gr Brocholi Sprouts

[tn12 in reply to RMontana]

I grow them for my husband. He eats 100g a day. I researched that gives him 60mg of sulfuraphane which is the dose that is recommended to have any effect on prostate cancer. I looked at BROCQ and not crazy about the added ingredients. Plus you are never 100% sure of what's in it.

[ElRanchoDePoisonIvy in reply to tn12]

About how many cups is 100 grams?

[tn12 in reply to ElRanchoDePoisonIvy]

It's 3.5oz. the same as the plastic clamshell you get at the grocery store hard to say in cups, depends if you pack them in tight or not.

[RMontana in reply to tn12]

OK, but 100g sprouted what is the amount in volume that is eaten? That was my question...a cup or 90 gr/ 3.5 Oz of sprout seeds has to occupy some volume once sprouted. Is this a bowl or what amount are you finding is produced from sprouting 100 g of seeds? So its the issue of concentration of compound which is why we sometimes take supplements. The amount of raw material we would need to eat may be excessive...but I dont know?

Also, what brand to you like or buy and is there any method you found better than others to grow it. TNX

[tn12 in reply to RMontana]

I use 4 levelled tablespoons of seeds per jar. See pics One jar yields 200g of sprouts. I measured 100g. It's 1.5 cups, which is equivalent to 60mg of sulfuraphane daily. I buy the Mumm's organic sprouting seeds.

Sprouts

[tn12 in reply to RMontana]

This is the jar I use

800ml mason jar

[RMontana in reply to tn12]

...that is the remaining question...is it 100g or sprouted seed or 100g of raw seeds that gives you the 60mg or Sulforaphane...they are not the same. I will check this out. But if its 100g of sprouted seeds then its not that much to eat for sure...I will look into growing my own as well. TNX

[tn12 in reply to RMontana]

I'm pretty sure it's 100g sprouted. The sulfuraphane comes from the greens. Good luck! It's super cheap and easy to do. Let me know if you have any questions.

[tn12 in reply to RMontana]

This is from 4 tbsp of broccoli seeds.

This is the finished batch of the last pic in case you were curious.

[ElRanchoDePoisonIvy]

What’s the brand that is stabilized?

[RMontana in reply to ElRanchoDePoisonIvy]

This is the only one that I can find...I just ordered my refill tonight...again, I am not affiliated with this supplement and am not involved any way in it sale or production...I am following my research. Rick

BROQ Sulphorafane Supplement

[RMontana in reply to RMontana]

Took one more look at the study from AACR...the choice of 60mg of Sulforaphane was a SWAG (let me know if you need that translated)...there was no other reason to choose that amount, other than to double what worked initially...which was 30mg a day! Take a look at the study, last para, INTRODUCTION...so my point is that 20mg each day for years has an effect...more may be better, but less does not mean there is no effect!

INTRODUCTION; In an unpublished non–placebo-controlled pilot study of 15 patients with biochemical recurrence following radical prostatectomy, with or without adjuvant or salvage external radiotherapy, treated with 30-mg doses of oral stabilized free sulforaphane daily during 3 months; we observed that sulforaphane was very well tolerated and that the PSA doubling time increased from 10% to 400% for 80% of the patients. Assuming that sulforaphane has a dose- and time-related effect on the reduction of PSA progression, we chose to investigate in this study the effect of a stabilized free-form sulforaphane using a daily dose of 60 mg for a longer treatment time (6 months) in the same population of patients.

doi.org/10.1158/1940-6207.C...

[tn12 in reply to RMontana]

That's good news. I still believe in growing them. It's 100% natural, easy and inexpensive and you know what you are ingesting