Hi, I would like to know what painkiller works best. I am currently on Predisolone, Cellcept and Methotrexate. I thought I was getting better, but then I notice about 3 new flare ups on my feet. Which instantly got me depress. It is really difficult to deal with the pain when I'm at work. Its really hard, I was taking pethidine. But it tends to get me woosy at work and spaced out, lol. To think after 6 years with Vasculitis, I would be able to cope. I've been on and off medication. This year got a 2 month remission, now I am back to square one. Sigh! Sorry if I sound depress.