Bladder irritation after cyclophosphamide.

[pigeon12]

I was diagnosed with GPA vasculitis in 2016 and given two doses of cyclophosphamide.I was given Mesna tablets at the same time to protect the bladder as this was a known side effect of the treatment. Unfortunately after the second dose I became extremely ill very quickly and suffered vomiting which probably meant the Mesna tablets never got to do their job. Now, each morning I wake up so desperate to pee I can barely get to the bathroom. I have no trouble in the day time only on waking. Does anyone else share this problem?

[Hidden]

I had cyclophosphamide as part of my treatment for Breast cancer. We were strongly advised to have a glass or two of lemon juice whilst it was being infused, to counteract the affect on the bladder. I know this doesn't help you now, but maybe you could wear an incontinence pad in bed so that in the morning you would have a better chance of reaching the bathroom before urinating.

[Tbrz]

Hi, I have GPA and had 9 cycles of cyclophosphamide, since then I have had constant bladder issues. I need the toilet more, can’t hold myself and like you when I need to go I have to get to the toilet quickly. I feel constantly bloated as well and I am constantly getting infections. I have mentioned this, but the doctors have not really been interested, so am just living with it. I also had the Mensa tablets, but it’s not been right since.

[AmyS1]

Get it checked out asap. This might sound worrying but cyclophosphamide increases your risk of bladder cancer. Also it could be something like steroid induced diabetes or diabetes a very common illness. Hope that it resolves soon.