Hello lovely, knowledgeable folks - belated 'Happy New Year' to you all!
After an increase of levothyroxine (LT) in November 2023 from 50 mcg/ day to 75 mcg/day, I had back-to-back tests on 02 Jan. (Medichecks - professional blood draw) and 03 Jan. (NHS), to see comparable results. Both tests were done following suggested protocol on here, i.e. ~09:00, ~24 hrs since taking LT, only water before test. My latest, updated spreadsheet is shown above.
Firstly - reassuringly, the Medichecks and NHS % through range values for TSH and FT4 are reasonably close, which gives a nice cross-validation of the results. [NOTE: there are NHS results from 25 Oct. 2023 that showed some, small improvements - I was still on 50 mcg/day at that stage, AND the test was not taken under optimal conditions, i.e. it was at 16:30, ~31 hrs since last LT, some intake but all liquid (water, tea & soup), blood was like treacle and wouldn't come out at the first attempt - I was just bruising under the skin, so the phlebotomist had to switch to the other arm! So I'm taking those values with a pinch of salt. The Oct. blood draw was for a prolactin measurement so I wasn't expecting them to do thyroid levels as well.]
Secondly - flippin' Medichecks has changed the lab that they use (used to be Innuvi, now Eurofins)... I only just noticed and had to go back and check all the ranges, update the ones that are different (there are several different ranges in the Ultimate Performance Test that I had, although the thyroid ones are the same), and recalculate the % through range *TUT*!
Thirdly - despite the LT increase to 75 mcg/day - which is close to my, theoretical, replacement dose by weight (I know it's not the numbers but how you feel that indicates correct replacement levels) - the increase has, apparently, had absolutely NO effect on my TSH, FT4, or FT3... if anything, things are very slightly worse compared to September last year. I am completely confused... where is the extra LT going... what's it doing??? BTW, I'm tiny (about 49 kg and 5 feet tall)... using the 1.6 x weight theory, my replacement dose should be about 79 mcg/day - so, not that far away from 75 mcg/day.
I have not had any real improvement in symptoms... still tired, still losing hair, still dry, sandpaper skin on face, still aching joints, still massive amounts of fizzing and tingling - particularly in left arm and hand, and the tinnitus is driving me mad.
In fact, despite assiduously taking Fe, vit. D + K2 (M7) spray, Mg, B12, and B-complex spray, the only thing that has changed in any positive manner is B12... which is now reported by Medichecks as over range (this is one of the ranges that has changed so I now no longer have an actual value - it's just reported as >150) and they've said stop supplementing. What's going on - any ideas?
Apart from B12, the other thing that's spiralling out of control is my prolactin level - it's astronomical: more than 4x the upper range value and increasing. The GP has requested a contrast-MRI, which is booked for 18 Jan., to look at my pituitary. Could it be my pituitary that's causing the apparent unchanging TSH, FT4, and FT3 levels... not sure how - just clutching at straws?
Thank you for reading through all that! As ever, any thoughts or input very much appreciated 🙏😊
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