Accord levothyroxine 100 mcgm

[crimple]

Has anyone noticed any issues with the above Levothyroxine tablets?

My latest packet lot no is ATC 60 expiry 12/24 as was previous pack, so 8 weeks worth

I have not been feeling too clever over recent months, put it down to a lot of stress in my life. Did a Medichecks test and results were TSH 0.005 (0.27-4.2) usual warnings re osteoporosis!

T4 16.6 (12-22) 46% through range

T3 5.7 (3.1-6.8) 70% through range

I was due a GP bloods test for prescription review and got the results yesterday:

TSH (0.05) comment this is normal for this patient- hooray

T4 11.1 (7.8-18) 32% through range

T3 5.64 (3.5-6.8) 65% through range

I noticed that the difference between NHS lab number and Medichecks number for T4 is quite marked 32% against 46% the T3 difference I would think is par for the course.

I take 100mcgm Levo and 15 mcgm T3 (Sigma Pharma) each day

I looked back through previous years: July 2022 T4 35% through range T3 86%

July21 T4 62% and T3 67% again T4 difference is noticeable

Vitamins are all good , ferritin over range, waiting for genetic test result for haemachromatosis as daughter has been diagnosed homozygous for the gene.

Thank you for reading this far, struggled to set it down in readable form, slight brain fog perhaps!

[helvella Administrator Thyroid UK]

We've had quite number of posts over the past months questioning Accord levothyroxine - 50 and 100 microgram tablets.

But not so many that we are certain there is a major issue.

I do encourage putting in a Yellow Card report if you even suspect an issue.

🟨 Making Yellow Card Reports 🟨

healthunlocked.com/thyroidu...

[helvella Administrator Thyroid UK in reply to helvella]

Meant to say, I did put in a Yellow Card on Accord myself.

And switched to Aristo/Vencamil which has been fine.

[crimple in reply to helvella]

Thanks for this info helvella I will send in a yellow card as I haven't done anything different with respect to when I take the tabs or when I do the tests. Been the same for at least last 5 years.

So now the conundrum is what do I do? Ask for more t3 2.5 or 5mcgm or take more Accord. I am very reluctant to switch brands due to my issues with fillers. TEVA is absolutely a no no and anything containing acacia powder.

I shall contact my GP after BH but really need to have an action plan firmly in mind!

[helvella Administrator Thyroid UK in reply to crimple]

Well, obviously there are no guarantees, but Aristo has no lactose, no mannitol and no acacia. And some do not get on with it.

What Vencamil contains

• The active substance is anhydrous levothyroxine sodium.

Each tablet contains 100 micrograms of anhydrous levothyroxine sodium.

• The other ingredients are microcrystalline cellulose, maize starch, heavy magnesium oxide, sodium starch glycolate type A and magnesium stearate.

medicines.org.uk/emc/files/...

[Sparklingsunshine in reply to helvella]

If I can just butt in what issues are people experiencing? I take Accord as a named brand and now I'm a bit concerned.

[helvella Administrator Thyroid UK in reply to Sparklingsunshine]

I felt some were sub-potent.

I had been taking Accord for many years as my prime (100 microgram) tablets but also had some 50 microgram tablets. Both seemed less effective.

(I had a considerable time ago put in a Yellow Card because they were crumbling as I took them out of the blister pack. That did seem to get resolved.)

[crabapple in reply to helvella]

Agree crumbling does seem to have been sorted.

[Sparklingsunshine in reply to helvella]

Thanks Helvella, is this an issue for recently manufactured Accord or has it been going on for sometime?

[helvella Administrator Thyroid UK in reply to Sparklingsunshine]

I switched over to Aristo last year. And the posts about it have been going on for at least a couple of years. But only a small number - not a torrent.

It is so very difficult to know what makes people flip from just accepting something to asking for something else, posting, putting in Yellow Cards.

The ideas that runs through my head is that if someone is on slightly too little, or only just enough, they'll feel worse faster. Whereas someone who has a slightly high dose might not notice any change. But that could just be me trying to rationalise things.

[crimple in reply to Sparklingsunshine]

sparkling sunshine, I am experiencing under medication symptoms such as headaches ((which I get if I have missed a dose) lack of energy, don't ask me to do anything in the afternoon, musculoskeletal issues playing up again, struggling with mild brain fog too.

[Sparklingsunshine in reply to crimple]

Sorry to hear that, are these recently manufactured tablets? I stopped using Levo for several months as I was trialling NDT/ NDT Levo combo. So I've got rather a glut and am working my way through late 2022 and early 2023 batches. I hope you're feeling better soon. Have you got enough to temporarily increase your dose?

[crimple in reply to Sparklingsunshine]

Sparkling sunshine the boxes I have are valid until 12/2024 and were dispended in May I get a 2 month scrip and have 2 months in hand due to issues mainly with getting the Sigma Pharma. I am undecided whether to add another 2.5 mcgm T3 or mess about trying to get 12.5cgm from accord 50 mcgm tablets. I tend to be overly sensitive to fillers etc. and due to go away mid sept so could do with feeling good! I am going to ponder over weekend.

[crimple]

helvella I have now sent in my yellow card and will ponder over the weekend what to do with respect to future meds. and conversation with GP. I was a victim of TEVA 100 mcgm issues in 2012. This is a very nasty case of deja vue. Thank heavens for private testing being readily available.

[helvella Administrator Thyroid UK in reply to crimple]

I too had the "old formulation" Teva issue - just as I was titrating my dose - and wondering why I seemed to be going backwards.

[crimple in reply to helvella]

helvella what an absolute nightmare. It was thanks to that b....s up that I found TUK and gradually learned to advocate for myself and eventually asked for T3. It was easy enough to see that I was a poor converter, but of course most medics don't have a clue what we are talking about.

To be fair my current GP's will at least listen and have on record that I accept any osteoporosis issues and heart issues that might arise due to my non existent TSH levels.

Wouldn't life be great if the powers that be ever decided to stop testing TSH when we are on thyroid meds. It would be even better if all medics were educated about T3, why we need it. I will dream on.

[Ellie-Louise]

I haven’t noticed anything different, tablets are hard enough not to crumble when I press them out. (Accord 50’s)