Iron help please: Recent blood results Serum iron... - Thyroid UK

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Iron help please

clubby29 profile image
19 Replies

Recent blood results

Serum iron 20. 11-28 Transferrin 2.4 2-3.6

Sat. Trans 36% 15-50 Ferritin 158 no range given

Serum B12 515 197-771 Folate 4.9 no range given

Vit D 54.3

HB 131 135-175 RBC 4.2 4.5-5.5

To my untrained eye the bulk of this didn’t look too bad, my problem why is HB and RBC below range. I’ve had problems with lack of strength and some muscle soreness after a busy week at work, I’ve also just noticed I’ve been borderline anemic for a few years, not that my endo cares he’s all about TSH.

Can anyone shed any light?

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clubby29
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radd profile image
radd

clubby29,

'Serum iron 20. 11-28, Transferrin 2.4 2-3.6

Sat. Trans 36% 15-50, Ferritin 158 no range given

Serum B12 515 197-771 Folate 4.9 no range given

Vit D 54.3

HB 131 135-175 RBC 4.2 4.5-5.5'

VitB12 & folate look ok, Vit D looks low.

Iron levels are good, but haemoglobin & RBC are under-range.

Do you have Hashi? I have looked in your profile & previous posts and can't tell but your results are classic for anaemia of chronic disease.

This happens when iron levels are good but RBC and/or haemoglobin are low due to issues such as impaired erythropoiesis (production of RBC’s) or an unusually short life of RBC’s.

This is associated with under-lying chronic inflammation which on this forum is usually caused by autoimmune conditions such as Hashimotos with elevated thyroid antibodies, also rheumatoid arthritis, lupus, etc. Research is showing that a constantly high alert immune system (as in Hashi with elevated thyroid antibodies) produces substances that influence the development/storage/transport of iron.

Cytokines are proteins stimulating/inhibiting the immune system and hepcidin (hormone produced in the liver that helps regulate the metabolism/transport of iron) is particularly stimulated by a cytokine known as interleukin-6 (IL-6) which is stimulated by thyroid antibodies in Hashimotos.

An excess of hepcidin causes too much iron to be trapped within cells, so lowering the amount available to produce haemoglobin. Therefore, the treatment is to reduce inflammation by reducing thyroid antibodies.

clubby29 profile image
clubby29 in reply toradd

Hi thanks for reply, yes I have hashimotos but haven’t had antibody test for about 3 years. Have been gf for about 6yrs and almost dairy free for 2yrs

radd profile image
radd in reply toclubby29

clubby29,

That's good but there obviously something else driving the inflammation then.

Nightshades? Other health issues? Other meds interfering with thyroid meds? Are thyroid meds optimal? Maybe something like histamine, mould, household dust allergy? Elevated oestrogen? The list is too numerous to mention because it can literally be anything that becomes chronic.

We know we haven't got underlying inflammation because we don't hurt. There are no aches and pains, no swellings and everything just works better.I have pain in my wrists and thumb joints at the moment. Trying to go dairy free but not very successfully 😞

.

This explains Anaemia of Chronic Disease but is a little hard going 😬

pathology.jcu.edu.au/webpat...

fiftyone profile image
fiftyone in reply toradd

I, too have been suffering from pain in my wrists and thumb joints. Could you explain in non technical language what you found, or think, was causing this. My own doctors have no idea (done blood tests and xrays)

SarahJane1471 profile image
SarahJane1471 in reply tofiftyone

Carpal Tunnel 🤷‍♀️

Roadrunnergreg profile image
Roadrunnergreg in reply toSarahJane1471

Carpel tunnel. Is in the vast majority of cases related to low levels of vitamin D

SarahJane1471 profile image
SarahJane1471 in reply tofiftyone

It’s very common symptom of hypo . I’ve had it for years

fiftyone profile image
fiftyone in reply toSarahJane1471

are you well medicated? are your levels good? Do you get carpal in spite of adequate medication or only if your levels fall?

SarahJane1471 profile image
SarahJane1471 in reply tofiftyone

Carpal tunnel for 6 yrs. I have steroid injections which last about 9 months. But only treated for hypo since last July. So I’m not sure if I’ve been hypo since the start of Carpal Tunnel. Chicken and egg 🤷‍♀️. I don’t want any more steroid injections so will have the operation soon as symptoms are coming back now. But I suspect CP damage is done.

fiftyone profile image
fiftyone in reply toSarahJane1471

what was the steroid injection like? I was offered one but turned it down because they said I've have to rest my hands. Impossible!! Was taking 18 painkillers a day start of Jan. Now down to 4 paracetamols a day. The doctors never mentioned carpal tunnel though. How were you diagnosed?

SarahJane1471 profile image
SarahJane1471 in reply tofiftyone

Have you tried the wrists splints at night? It helps. You only have to take it easy after the injections for 48hrs ( no lifting heavy things) . Injections are uncomfortable for a few minutes. Carpal Tunnel is easily diagnosed by a GP. Or yourself. Turn your hands palms up and bend towards yourself/upwards at 90 degree angle. If your fingers go tingly/ numb then you have it🤷‍♀️Could be something different you have. I’m sure someone would have said CP by now.

radd profile image
radd in reply tofiftyone

fiftyone,

It is common to have clusters of certain autoimmune disease & I think my own aches/pains are possibly the beginnings of RA which my sister has alongside her Hashi.

Did your GP test ESR, CRP, etc …. anything indicating any inflammation? Also rheumatoid factors (the attacking proteins) and anti-CCPs ? These are antibodies that don’t diagnosis on their own but indicate a good chance of RA.

The other suggestion is carpel tunnel that is common with Hashi & RA, and I have lost some thumb grip strength, ie difficulties in holding a glass. Carpel tunnel usually becomes more painful at night because there is less movement to keep blood flowing. My aches/pains are worse in the morning and lessen with movement, rotating my wrists, shaking and stretching my hands wide, and flicking my fingers. It is also possible to have both conditions together. Oh joy 🤣.

I’m waiting for an imminent shoulder op after a cycling accident, so can’t think about RA, etc at the moment. Am still in the ‘hoping it will just go away’ stage 😬, and revving up to adopt a very strict anti-inflammatory diet.

Post your labs for members to comment if you wish.

fiftyone profile image
fiftyone in reply toradd

Was referred to a musculoskeletal clinic.They tested for rheumatoid athritis. just negative. they tested for inflammation. only normal amount. nothing to worry about. Nothing on xrays. Doctors have no idea what it is!! Getting better, very gradually.

radd profile image
radd in reply tofiftyone

fiftyone,

Oh good. Hope your recovery continues. I hoping the coming of the summer helps mine 😊

SlowDragon profile image
SlowDragonAdministrator

vitamin D on low side

Optimal vitamin D is at least around 80nmol and around 100nmol maybe better

Folate you need range

(usually either 3-20 or 8-60)

What vitamin supplements are you currently taking

What are your thyroid levels?

Always test early morning before, ideally before 9am and last dose levothyroxine 24 hours before test

clubby29 profile image
clubby29 in reply toSlowDragon

Hi FT3 6.6. 3.1-6.8. Ft4 18.2 12-22 tsh 0.01Currently no vitamin supplements 150 levo, 20 t3

Strangely I’ve been on same dose for about 18 months but this is by far the highest readings I’ve had, the only thing to change is I no longer split dose my t3.

SlowDragon profile image
SlowDragonAdministrator in reply toclubby29

Even if you don’t normally split your T3

On day before test splitting T3 into 2 or 3 smaller doses spread through the day so that last 5mcg dose is approx 8-12 hours before test

And last dose levothyroxine 24 hours before test

Testing early morning, ideally before 9am

Look at improving low vitamin D and get folate range

Likely to need daily vitamin B complex

clubby29 profile image
clubby29 in reply toSlowDragon

Hi thanks for reply, my paperwork just states under 3 deficient so presumably 3-20. For folate

Eddie83 profile image
Eddie83

Izabella Wentz says the ideal ferritin is 90. My doc has told me ideal ferritin is 100. So your ferritin at 158 is a bit high, but not disastrously so.

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