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Started Levo and wondering when I might start to feel better - any supplements I need to add?

Sleepybunny21 profile image
6 Replies

I finally managed to get the GP to try me on 25mcg Levothyroxine, which I have been taking for just under a month now. My results before starting were

TSH - 5.91 (0.34-5.60mu/l)

Serum free T4 - 10.2 (7.9-20pmol/l)

Serum T3 - 6.2 (4.00 - 6.60pmol/L)

I have also stopped eating gluten, and am also taking

-Vitamin B Compound

- Ferrous fumerate 322mg

- Vitamin D3 1000iu

-Calcium, magnesium, Zinc

-Vitamin C

Are there any other supplements I could start taking? I still feel as dreadful as ever, a bit worse if anything. I know it's early days, but I am desperate to start feeling some improvement. My next blood test isn't until the beginning of December, so I have no idea what my thyroid hormones are doing.

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SlowDragon profile image
SlowDragonAdministrator

Previous post confirms autoimmune thyroid disease also called hashimoto’s

How old are you

Standard starter dose Levothyroxine is 50mcg unless over 60 years old

Starting on 25mcg can make you feel worse

Make sure to get blood test 6-8 weeks after each dose change or brand change in Levothyroxine

Always test thyroid levels as early as possible in morning before eating or drinking anything apart from water and last dose Levothyroxine 24 hours before test

Likely to need several further increases in Levothyroxine over coming months

Sleepybunny21 profile image
Sleepybunny21 in reply to SlowDragon

I'm 30. I think he started on such a low dose out of caution, as I'm 'subclinical'

Is it likely to have made no difference to my thyroid levels?

It's so frustrating, as its been such a battle to even get prescribed levothyroxine, I'm worried they won't allow me to increase the dose.

SlowDragon profile image
SlowDragonAdministrator in reply to Sleepybunny21

Many GP’s don’t understand….Levothyroxine doesn’t “top up” your thyroid hormones, due to feedback mechanism, Levothyroxine replaces your thyroid hormones

So starting on low dose can make you feel worse, push for next dose increase after you get blood test results

Dose levothyroxine should be increased slowly upwards in 25mcg steps

guidelines on dose levothyroxine by weight

Even if we frequently don’t start on full replacement dose, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until eventually on, or near full replacement dose

NICE guidelines on full replacement dose

nice.org.uk/guidance/ng145/...

1.3.6

Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.

Also here

cks.nice.org.uk/topics/hypo...

gp-update.co.uk/Latest-Upda...

Traditionally we have tended to start patients on a low dose of levothyroxine and titrate it up over a period of months. RCT evidence suggests that for the majority of patients this is not necessary and may waste resources.

For patients aged >60y or with ischaemic heart disease, start levothyroxine at 25–50μg daily and titrate up every 3 to 6 weeks as tolerated.

For ALL other patients start at full replacement dose. For most this will equate to 1.6 μg/kg/day (approximately 100μg for a 60kg woman and 125μg for a 75kg man).

If you are starting treatment for subclinical hypothyroidism, this article advises starting at a dose close to the full treatment dose on the basis that it is difficult to assess symptom response unless a therapeutic dose has been trialled.

BMJ also clear on dose required

bmj.com/content/368/bmj.m41

bestpractice.bmj.com/topics...

How much do you weigh in kilo

ESSENTIAL to test vitamin D, folate, ferritin and B12

TSH should be under 2 as an absolute maximum when on levothyroxine

gponline.com/endocrinology-...

Replacement therapy with levothyroxine should be initiated in all patients to achieve a TSH level of 0.5-2.0pmol/L.

NHS England Liothyronine guidelines July 2019 clearly state on page 13 that TSH should be between 0.4-1.5 when OPTIMALLY treated with just Levothyroxine

Note that it says test should be in morning BEFORE taking levothyroxine

Also to test vitamin D, folate, B12 and ferritin

sps.nhs.uk/wp-content/uploa...

Bloods should be retested 6-8 weeks after each dose change or brand change in levothyroxine

Which brand of levothyroxine are you currently taking

SlowDragon profile image
SlowDragonAdministrator

Which brand Levothyroxine are you currently taking

Remember to stop taking vitamin B complex a week before ALL BLOOD TESTS as contains biotin

greygoose profile image
greygoose

am also taking

-Vitamin B Compound

- Ferrous fumerate 322mg

- Vitamin D3 1000iu

-Calcium, magnesium, Zinc

-Vitamin C

Did you get any of these nutrients tested before starting supplements? If so, what were the results and ranges.

Although you need to take magnesium - most people are deficient, anyway, and taking vit D will use up your magnesium - it's unlikely you need calcium. It's very rare to be calcium deficient in the western world, and taking calcium supplements can cause more problems than it solves. They are very badly absorbed, and tend to build up in the arteries and soft tissues.

On the other hand, when taking vit D, you really need to take vit K2-MK7 with it. Taking vit D increases absorption of calcium from food, so you need to take vit K2 to make sure it gets into the bones and teeth and doesn't build up in the soft tissues and arteries.

Which form of magnesium is in your pills?

Zinc needs to be balanced with copper, but most hypos are usually deficient in one an high in the other, so really a good idea to get them both tested before supplementing either.

Do you take all these supplements at the same time? Because iron needs to be taken two hours away from everything, except vit C, otherwise it will block absorption of the other vitamins, and bind with the calcium. So you won't really be getting any benefit from any of it.

Vit D, magnesium and iron need to be taken at least four hours away from thyroid hormone. The others at least two hours away. Vit B12 needs to be taken two hours away from vit C. Sorry, but it's a bit complicated. :)

SeasideSusie profile image
SeasideSusieRemembering

Sleepybunny21

From what I can see of our previous posts you posted these wre your results 4 months ago from a then recent test:

Serum Ferritin - 28 (11 - 307ug/l)

Serum Vitamin B12 - 266 (120 - 625ng/l)

Serum Folate - 6.6 ug/l (>3)

Did you request an iron panel from your GP as suggested to see if you had iron deficiency or iron deficiency anaemia?

As you are supplementing with D3, did you test first, what was your result?

Which B Complex are you taking, and how much?

With such a low B12 did you check for signs and symptoms of B12 deficiency -

b12deficiency.info/signs-an...

b12d.org/submit/document?id=46

If you had any your GP should have tested further for B12 deficiency and pernicious anaemia before starting to supplement with B12 or B Complex.

It would be a good idea to retest, especially an iron panel as this should be done regularly when supplementing with iron, every couple of months.

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