Raised TPO antibodies suggest Hashimoto's. Hashi's is where the immune system attacks and gradually destroys the thyroid which eventually leads to hypothyroidism. How long it takes isn't really predictable. Treatment wouldn't be offered until the raised antibodies are accompanied by a TSH showing over range (but not necessarily reached 10 which is when Primary Hypothyroidism is diagnosed) or if FT4 goes below range.
Some members with Hashi's have found that adopting a strict gluten free diet can help, although there is no guarantee.
Gluten contains gliadin (a protein) which is thought to trigger autoimmune attacks so eliminating gluten can help reduce these attacks.
You don't need to be gluten sensitive or have Coeliac disease for a gluten free diet to help.
Supplementing with selenium l-selenomethionine 200mcg daily is said to help reduce the antibodies, as can keeping TSH suppressed.
Hashi's and gut absorption problems tend to go hand in hand and can very often result in low nutrient levels or deficiencies. It's essential to test Vit D, B12, Folate and Ferritin and address any problems. You are welcome to post these results, including reference ranges (plus units of measurement for Vit D and B12), for comment and suggestions for supplementing where necessary.
I'm afraid I can't help with the high gamma globulin.
I don't have Hashi's so I can't answer from experience, but symptoms and test results fluctuate with Hashi's. How and when the immune system attacks the thyroid is pretty random so you can have periods of stability (rather than remission) then maybe a false "hyper" episode when the attack causes thyroid hormone to be released, then after that you will be a bit more hypothyroid as a bit more of the thyroid would have been destroyed. There will come a point where the thyroid has been destroyed enough to cause hypothyroidism then that is it, the thyroid wont then be able to produce enough hormone itself and replacement hormone (Levothyroxine) will be needed and as the thyroid can't regenerate replacement hormone is for life.
If you look to the right of the page (on a PC, probably scroll down on another device) you will se TOPICS and one of those is HASHIMOTO'S with over 3,000 posts. It might be worth having a look through some of those as well as the links I gave previously.
I don't know if you can call it 'remission' as such, but you can have a prolonged period of euthyroidism in between a hyper phase and going back to hypo. That's often when people claim to have 'cured' or 'reversed' their Hashi's by whatever means. But, it doesn't last.
For full Thyroid evaluation need TSH, FT4 and FT3 plus both TPO and TG thyroid antibodies tested.
Also EXTREMELY important to test vitamin D, folate, ferritin and B12
Low vitamin levels are extremely common, especially with autoimmune thyroid disease (Hashimoto’s or Ord’s thyroiditis)
Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water .
This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)
Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins
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