Tingling and pain in hands and feet - could it ... - Thyroid UK

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Tingling and pain in hands and feet - could it be the B12?

WhyAmISoTired profile image
8 Replies

Hi all, I got some blood tests recently. Here they are:

TSH 0.82 mU/l (0.30-4.50)

FT4 1.24 ng/dl (0.80-1.70)

FT3 3.14 ng/l (2.30-4.20)

Ferritin 108 (15-291)

Vitamin D 26 ng/ml (11-43)

Vitamin B12 318 ng/l (211-911)

Folic acid 9.32 (>5.38)

I realized my B12 is quite low, and my doctor agrees, so I have been getting B6-B9-B12 injections. I've had 4 so far, the first was about a month ago. Thank you so much SlowDragon for suggesting I test these! I am also getting some vitamin D supplements and trying to sunbathe when it's sunny.

Since I started the injections I've been having issues with tingling in my hands and feet. It started out with mild constant tingling in my feet and fingertips, and I thought it was getting better, but periodically I get it again and it spread to my arms as well. Sometimes it's more tingling and sometimes it's more painful.

I know it could be the nerves repairing after the B12 was replenished, but I got a bit worried when the tingling came back after days of feeling better. Has anyone experienced this? Is there anything else this could be related to? (maybe the injections are a coincidence??) Two days ago I got a gastroscopy and yesterday I was feeling understandably a bit low after the stress of the procedure, and low and behold tingling came back in force.

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8 Replies
SlowDragon profile image
SlowDragonAdministrator

Getting thyroid levels retested after 6-8 weeks on improving low vitamin levels

You might want a daily vitamin B complex too

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid) may be beneficial.

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

chriskresser.com/folate-vs-...

Many Hashimoto’s patients have MTHFR gene variation and can have trouble processing folic acid.

thyroidpharmacist.com/artic...

B vitamins best taken after breakfast

Igennus Super B is good quality and cheap vitamin B complex. Contains folate. Full dose is two tablets per day. Many/most people may only need one tablet per day. Certainly only start on one per day (or even half tablet per day for first couple of weeks)

Or Thorne Basic B is another option that contain folate

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

How much levothyroxine are you currently taking?

Looking at previous posts....are you really only on 50mcg levothyroxine

That’s only a starter dose

Dose levothyroxine should be increased slowly upwards in 25mcg steps (or 12.5mcg if sensitive to dose change) Bloods retested 6-8 weeks after each dose increase

Levothyroxine doesn’t top up failing thyroid, it replaces it. So it’s important to get dose increased upwards as fast as tolerated.

WhyAmISoTired profile image
WhyAmISoTired in reply to SlowDragon

Hi SlowDragon, I am on 75mcg thyroxine since about 3 months.

SlowDragon profile image
SlowDragonAdministrator in reply to WhyAmISoTired

So time to get thyroid levels retested after 6-8 weeks on higher dose levothyroxine

Pins and needles is frequently linked to being under medicated for thyroid (as well as low vitamins)

Do you always get same brand of levothyroxine at each prescription

all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water .

Last dose of Levothyroxine 24 hours prior to blood test. (taking delayed dose immediately after blood draw).

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

WhyAmISoTired profile image
WhyAmISoTired in reply to SlowDragon

These blood tests were taken 6 weeks after my last increase (from 50 to 75). I have been on the same brand since I started on 75mcg.

SlowDragon profile image
SlowDragonAdministrator in reply to WhyAmISoTired

So Ft4 is only 49% through range Ft3 only 44% through range

Helpful calculator for working out percentage through range

chorobytarczycy.eu/kalkulator

Most people when adequately treated will need Ft4 and Ft3 at least 60% through range

Your results show you are still under medicated and ready for next dose increase in levothyroxine

You might increase by 12.5mcg initially (75mcg and 100mcg on alternate days)

guidelines on dose levothyroxine by weight

Even if we frequently don’t start on full replacement dose, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until eventually on, or near full replacement dose

NICE guidelines on full replacement dose

nice.org.uk/guidance/ng145/...

1.3.6

Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.

Also here

cks.nice.org.uk/topics/hypo...

gp-update.co.uk/Latest-Upda...

Traditionally we have tended to start patients on a low dose of levothyroxine and titrate it up over a period of months. RCT evidence suggests that for the majority of patients this is not necessary and may waste resources.

For patients aged >60y or with ischaemic heart disease, start levothyroxine at 25–50μg daily and titrate up every 3 to 6 weeks as tolerated.

For ALL other patients start at full replacement dose. For most this will equate to 1.6 μg/kg/day (approximately 100μg for a 60kg woman and 125μg for a 75kg man).

If you are starting treatment for subclinical hypothyroidism, this article advises starting at a dose close to the full treatment dose on the basis that it is difficult to assess symptom response unless a therapeutic dose has been trialled.

BMJ also clear on dose required

bmj.com/content/368/bmj.m41

bestpractice.bmj.com/topics...

Guidelines are just that ....guidelines.

Some people need more .....some less

healthunlocked.com/thyroidu...

gabkad profile image
gabkad

Potential Side Effects of Too Much Vitamin B6

Taking more than 1,000 mg of supplemental B6 a day may cause nerve damage and pain or numbness in the hands or feet. Some of these side effects have even been documented after just 100–300 mg of B6 per day

Another bit of Google searching:

Potential Side Effects of Too Much Vitamin B6

Taking more than 1,000 mg of supplemental B6 a day may cause nerve damage and pain or numbness in the hands or feet. Some of these side effects have even been documented after just 100–300 mg of B6 per day

(I don't know why you are getting B6 injection in addition to B12. Find out how much

is in the shots. It's better to just get plain B12 or take it orally. If you don't have pernicious

anemia, you can take B12 orally.)

WhyAmISoTired profile image
WhyAmISoTired in reply to gabkad

Good news! I just checked and the shots only have 5mg of B6, so I should be fine. But thanks for pointing this out!!

jrbarnes profile image
jrbarnes

I get pain in my hands and tingling in my feet when my T4 is low. 75mcg on Levo also puts my T4 levels at 1.2 and I feel awful. My T3 had to be at least 3.8 to function normally, however the only way I could get that was if my T4 levels were around 1.9.

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