Has anyone heard if this?

[Batty1]

Effects of commonly prescribed nonsteroidal anti-inflammatory drugs on thyroid hormone measurements

Author links open overlay panelAlkaBishnoiM.D.abKennethLidonniciM.D.c

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doi.org/10.1016/0002-9343(9...

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Abstract

purpose: To assess the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on thyroid function tests.

patients and methods: Eighty-nine patients receiving NSAIDs and 22 control subjects not taking NSAIDs were studied in a cross-sectional survey at Veterans Affairs and University hospitals. Measurements of serum thyroxine (T4), free T4 index, triiodothyronine (T3), and thyrotropin (thyroid-stimulating hormone [TSH]) were obtained for all subjects.

results: Serum T4 measurements were lowered only in salsalate-treated patients, while serum T3 was depressed in patients receiving salsalate, diclofenac sodium, and naproxen. Serum T4 and T3 were unchanged in patients treated with diflunisal, ibuprofen, indomethacin, piroxicam, or sulindac. Serum TSH was normal in all subjects.

conclusions: Several NSAIDs can lower serum thyroid hormone concentrations, principally by interfering with the binding of T4 and T3 to serum carrier proteins; patients taking these drugs remain euthyroid. Awareness of these interactions may prevent unnecessary diagnostic or therapeutic interventions.

I was looking up thyroidectomy and arthritis and came across this science article above, I found it interesting. I do take at least one Advil or Advil Dual Action everyday and on bad days at least 2 maybe 3 a day. I wonder if this could be the reason why NO MATTER what thyroid meds Im on my TSH and the rest of my labs are always scraping the bottom of the ranges 🤷‍♀️.

[humanbean]

conclusions: Several NSAIDs can lower serum thyroid hormone concentrations, principally by interfering with the binding of T 4 and T 3 to serum carrier proteins; patients taking these drugs remain euthyroid. Awareness of these interactions may prevent unnecessary diagnostic or therapeutic interventions.

I haven't actually read it (it's the middle of the night), but the whole paper can be read here :

sci-hub.se/https://doi.org/...

I'm guessing that when they refer to people having lower levels of T4 and T3 and yet remaining euthyroid, what they actually mean is that the TSH stays within the reference range. The fact that TSH has no effect on how well people feel, and levels of T3 actually correlate with symptoms is apparently unimportant. Only TSH counts. Bah humbug!

[Batty1 in reply to humanbean]

First time I actually saw this article. I just thought it was interesting.

[humanbean in reply to Batty1]

I wasn't criticizing you for posting it. And I thought it was interesting too.

[Batty1 in reply to humanbean]

I didn’t think you were.

[tattybogle]

That's very interesting , thankyou. Maybe look into taking one of the ones that they say didn't affect T4 or T3. measurements.

"principally by interfering with the binding of T4 and T3 to serum carrier proteins;"

... i'd have to put my brain in to think what exactly that means / how that affects us getting enough T3.... but it's sunday so i'm not going to.

[Batty1 in reply to tattybogle]

Ive taken everything under the sun and find that for my PSA the only helpful over the counter has been advil and advil dual that gives a little relief.