I started Tru Thyroid five months ago. I must say straight away that I take one grain (60mg) of Tru Thyroid with one grain (60mg) of the TR Man.
In that time my TSH has gone from being fully suppressed to 32-32 on the last couple of blood tests. Clearly the Tru Thyroid does not appear to be potent enough, and I guess that when the TR Man runs out, and I go to two grains (120mg) of Tru Thyroid the situation will get worse.
Despite that, apart from the tiredness, I actually haven't felt bad. I seem to keep warmer since I started the Tru Thyroid, and my energy levels have been fine for a 70 year old with ME.
My endo wants me to supplement with some thyroxine (well, what else can he offer me?) and I will at least give it a try (well, what else can I do?)
But the bottom line is that Tru Thyroid doesn't appear to be very potent. I hope that this helps others in my position.