I have had hypothyroid symptoms for as long as I can remember but they have become much worse after an adverse drug reaction 2 years ago. I have tested all the hormones and the only abnormality was free t3/reverse t3 ratio, and somewhat high cortisol.
I have subsequently taken t3 only at good doses (up to 100mcg with blood tests which show ft3 a few points over range with little tsh and ft4) but my main symptoms of brain fog, in bubble, apathy, lethargy, have not improved at all. Clearly it has been doing something because I became less stiff, my temperature appeared to increase, and food seemed to be metabolised quicker.
The strange thing was that the first time I took t3 20mcg, I had a significant increase in energy, and my brain seemed like it was slowly coming out of the bubble i.e hearing and vision had moments of being much sharper as I remember when I was healthier.
Despite this, the next day and until now, many months later, I have yet to see improvements like these, I have increased and held dosage at 100mcg yet it seems to do nothing. I have also briefly went up to 140mcg for a week. No brand changes, thybon always.
Thanks for reading so far. Does anyone have any experience or knowledge for why this would happen. I have always taken active b vitamins, but recently I discovered that I have a slight zinc deficiency and relatively low copper, both of which I am currently correcting with no really clear improvements in symptoms yet.
I have seen studies which indicate zinc has a role to play in t3 receptor and DNA interactions but nothing much has happened in last 2 weeks of supplementation with a good form.