Thyroid UK

High T4

Please can anyone enlighten me

If hypothyroid why has T4 remained mid range with raised Tsh as high as 30 and on thyroxine tsh comes down T4 is raising....

I've read a lot but just don't get it

I do have high TPO antibodies 600

I felt fine with Tsh of 26 and t4 mid range pre diagnosis then got tonsillitis and became really unwell, this was treated with antibiotics and I was started on thyroxine.

Just want to feel well, so fatigued, awful dark rings around eyes, slim with puffy face, double chin that's so odd. Fast heart anxious

Just terrible and I don't get it. I was told thyroxine would help..... not me I don't think

5 Replies

Please can you confirm that you felt fine with a TSH of 26? Should this be 2.6? Thanks



The pituitary gland issues TSH to stimulate the thyroid gland when it detects low T4. Levothyroxine raises T4 level and when the pituitary detects sufficient T4 in the blood it reduces the TSH.

Simply put, TSH rises when T4 is low and TSH drops when T4 is high.

Thyroid peroxidase antibodies are positive for autoimmune thyroid disease (Hashimoto's). There is no cure for Hashimoto's which causes 90% of hypothyroidism. Treatment is for the low thyroid levels it causes. Many people have found that 100% gluten-free diet is helpful in reducing Hashi flares, symptoms and eventually antibodies.

1 like

Thank you for explaining I'm day 4 gluten free, off to buy some probiotics... trying to get a grip but a real awful struggle

Thank you



Some people have 'withdrawal' effects when they first go gluten-free but they should subside in a week or two.


Gp just called with results

Tsh 6

T4 15.7

She suggests under treatment and to increase to 100mcg daily

So hard when you feel so rough on a treatment for past 6 maths to take more


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