I have been prescribed 25 mcg cytomel to be taken 1 on empty stomach!! I've been very sick for 6 yrs unable to work live or hardly function. I asked my dr for thyroid meds and finally she calls this in because my tpo antibodies were 3x normal. I was diagnosed with hashi in 2010... I tried ndt a couple times over the years but failed. I'm starting out with only about 1 mcg 2 x a day because my body had slowed so far down I knew it would land me in a hospital taking it as she prescribed. Today was day 3 and felt fatigued and in bed must of day.. I'm thinking the stress hormones ( adrenaline). are starting to lower . I'm thinking I will increase tomorrow slightly . I've been doing 2 doses but have read how many follow dr Lowe and do 1.. I follow dr Ray peats work. He suggests using t3 by using some closely matching our own physiology (4) mcg an hour is around what I body makes. Well I know we are all different and I'm very sensitive to any uppers! But I don't want to be feeling worse if possible... I ordered naturethroid and am considering adding it. Not sure when I should try that? So advice please as to using this t3 .. I eat very pro metabolism diet no gluten no pufa low muscle meat.. So I'm eating dairy, gelatin , fruit , some meat , eggs ... I have felt better on this diet and not bedridden after 2 years!! Thank you!