I was untreated for hypothyroidism for years because my results were always more or less "normal". Instead I received all sorts of treatments for diseases I never had, just wasted time, money, health. I started retaining water year after I became ill. it was in 2009 and since then IT NEVER STOPPED. I gained 20 lbs of water weight in a week and another 16 lbs in the period of time after that. I am on T3 for several years now (before that I was briefly on NDT) and it gave me my life back since before it I was incapable to even walking without help and my mind was completely off. This is all fine now but water and mucin are still there. A bit more than a year ago I started taking diuretics, I did this last time years ago when I started swelling but stopped with them completely after an episode in which I was close to die, but it was not because of diuretics. At the moment I take 320 mg of Lasix and 200 mg of spironolactone. I started with 160 mg of Lasix but got resistant over time so I had to take more and more. I lost almost 24 lbs of water on diuretics and besides visible mucin, I got my looks and figure back, in my face as well since it was completely deformed from swelling earlier. I was taking diuretics every few days, but recently I have to do it every other or every day. Just last night I gathered 4 lbs of water, my face and whole body is puffed and I had to take diuretics again. Last winter I was diagnosed with insulin resistance. I was on Metformin and had terrible stomach and heart problems on it and just when I got used to it my hair started to fall big time, so I stopped with it and at the same time my hair was fine again. I took Berberine after that but had no results and stomach problem as well. Now I am of newest medication - Forxiga (depagliflozin) which exerts sugar through urine. My sugar is normal now, especially since I am on ketogenic diet but there is no change in water retention, so then it's not caused by insulin resistance. So what is it?? I am living with this question for 7 years now and I can't take it anymore. I am planing my life according to diuretics and I can't live like this any more, especially as they have less and less effect. I tried every single supplement and nothing worked. Only thing I haven't tried yet is ADH (Vasopressin) anti diuretic hormone antagonist. Primitive antibiotic Demeclocycline (Ledermycin) not produced in most of the countries now, except in India and few others, has that effect but I don't know how to get it or new drug for this - Tolvaptan but this one is extremely expensive. This is last thing I can try but who knows will they work. I don't know what to do. My organism is acting as it has to hold to all of water and won't let go of it although I drink enough if water. I am really fed up and tired, my face changes everyday, when I am full of water my eyes are half closed and my whole body hurts. Sorry for such a long post but can anyone help with any suggestion? Thank you.