I am on T3 for 2 years now (self-medicating - but doctors I go to know about that) and my life drastically improved on it. In fact all of my hypo symptoms are long gone and my life completely changed for the better. But although I lost weight since on it and water retention is less severe, on some parts of my body mucin was still present and I still wasn't able to pinch my skin. Recently I was diagnosed with insulin resistance and put on Metformin. Unlike T3 which I adore, Metformin is not an easy drug, in fact I had lot of problems getting on the dose I was supposed to. However, I noticed that some of my mucin is gone since I am on it (I also take diuretics every 4 or 5 days). Some of my skin is now possible to pinch. What are your experiences? Can mucin and water retention also be connected with insulin resistance and not only to hypothyroidism? Thank you.