1 and half grain of naturethroid, feel wired sometimes and depressed, only started taking 1.5 grains since 10 days, so way to go. i take meds in morning and wake up stressed. that could be because i also have sleep apnea and use c-pap at night which arouses my body by pumping air down my throat? how many grains does most people end up on when well? i think taking meds at night might be better? when should i take my other supplements, i take vit c ester, selenium, started taking 125mg of niacin for depression after reading about benefits for depression and anxiety and health benefits the flushing kind of niacin, cod liver oil, evening primrose. magnesium,calcium and zinc complex solgar. still get bouts of high anxiety starting to wonder if i have mitral valve prolapse or arial fibrillation, as panic disorder associated with MVP. i have had issues with panic and anxiety ever since i was 14 at school. got worse at 18 yrs old had a mini nervous breakdown, sweats at night for several weeks, racing thoughts, ended up with clinical depression, had counselling for 18 months and anti depressants but never was completely well, wondered whether thyroid issues started in late teens, as i had glandular fever at 13yrs and a relapse at 17. sometimes my heart flutters and pulse high even when not apparently anxious or panicy. any help or answers welcome.