help with test results please

these results are my son's from Geneva..He has been feeling unwell for a while but his GP has ruled out thyroid.

T4 107 (58-154)

TSH 2.25 (marked as High on Genova report)( 0.4-4)

FT4 22.8 (High) (10-22)

FT3 5.87 (2.8-6.5)

FT4:FT3 ratio 3.9 (2.0-4.5)

thyroglobulin 26.8 (0-40

peroxidase (TPO) 96.6 (0-35)

The accompanying text says Probable auto-immune thyroid disease.

Any thoughts most welcome please.

3 Replies

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  • I am sorry you haven't had a reply yet. I am not good at blood test results but this excerpt may be helpful as the antibodies are high:-

    2 I often see patients who have an elevated TSH but normal T4. How should I be managing them?

    The combination of a normal serum T4 and raised serum TSH is known as subclinical hypothyroidism. If measured, serum T3 will also be normal. Repeat the thyroid function tests in two or three months in case the abnormality represents a resolving thyroiditis.

    But if it persists then antibodies to thyroid peroxidase should be measured. If these are positive – indicative of underlying autoimmune thyroid disease – the patient should be considered to have the mildest form of hypothyroidism.

    In the absence of symptoms some would simply recommend annual thyroid function tests until serum TSH is over 10mU/l or symptoms such as tiredness and weight gain develop. But a more pragmatic approach is to recognise that the thyroid failure is likely to become worse and try to nip things in the bud rather than risk loss to follow-up.

    Treatment should be started with levothyroxine in a dose sufficient to restore serum TSH to the lower part of its reference range. Levothyroxine in a dose of 75-100µg daily will usually be enough.

    If there are no thyroid peroxidase antibodies, levothyroxine should not be started unless serum TSH is consistently greater than 10mU/l.

    ****

    Although you son's TSH is within normal range which doctor's use for diagnosing, this is another link which may also be helpful.

    thyroiduk.org.uk/tuk/testin...

    thyroiduk.org.uk/tuk/testin...

    The above is part of an article in Pulse Online by Dr Toft of the BTA.

  • Thank you Shaws and Sandy12.

  • This doctor also believes in genetic, autoimmune thyroid disease.

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