inflammatory myositis

[FranceMary]

After years with Venetoclax I now have inflammatory myositis Is there any connection known?

[lankisterguy Volunteer]

Hi FranceMary

I had to look it up, but here is a useful explanation:

arapc.com/inflammatory-myos...

Definition

Inflammatory myositis is a systemic autoimmune disease that has four forms: polymyositis, dermatomyositis, necrotizing autoimmune myositis and inclusion body myositis. Inflammatory myositis is more common in African-Americans compared to whites and in woman compared to men. Polymyositis affects adults in their 30’s to 50’s. Dermatomyositis commonly affects children ages 5-15 and adults ages 45-65. Myositis can occur in combination with other autoimmune diseases (e.g scleroderma and mixed connective tissue disease). The exact cause is unknown, but we do know that it is an autoimmune disease (the body’s own immune system attacks the muscles).

Symptoms

Myositis is characterized by the onset over several weeks of weakness in muscles close to the trunk – the upper arms/shoulders, thighs and sometimes the neck. Weakness is due to muscle inflammation and subsequent muscle damage. While weakness is the most prominent symptom, muscle soreness can also occur. Patients may notice difficulty getting out of a chair, putting things away in overhead cabinets, or trouble climbing stairs due to weakness rather than pain. Other symptoms can include shortness of breath from lung inflammation, joint pain, Raynaud’s syndrome (finger color changes and numbness in cold weather), and trouble swallowing. Patients with dermatomyositis often develop several different kinds of rashes including one on the hands (Gottron’s papules), a violet discoloration or swelling around the eyes (heliotrope), and/or across the back and chest (shawl rash; see images below).

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Here is a list of 303 past postings discussing autoimmune diseases in CLL:

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Here is a recent discussion about autoimmune issues in CLL patients, but the experts disagree on how much connection is proven. healthunlocked.com/cllsuppo...

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Len