Undetectable after 6 months

[Golflover1954]

I received six months of obinutuzumab And 400 mg Venetoclax. My oncologist did a bone marrow biopsy and a CT scan. The results of the CT scan were all normal lymph nodes and the results of the bone marrow biopsy were clear of any disease. I stopped Venetoclax and am Being monitored with a test called clonoseq. I’m excited.

[MistyMountainHop]

Great news! Go directly to the nineteenth hole🍻🥂

[lankisterguy Administrator Volunteer]

Hi Golflover,

Congratulations, you just hit the hole in one for CLL patients. Have that score card framed and displayed.

The Clonoseq test can often detect 1 CLL cell out of 1 million, so it may be several years until your CLL returns, hopefully many years.

Len

[Hilomom]

This is very comforting, reassuring news!

[Dragonfly2007]

That's fantastic news 🎉 not surprised you are excited!

[Stavrou1]

That's great news 🍾..

[dmmck]

Great news!!

[stevesmith1964]

Great news. Obinituzumab and Ibrutinib got me Stage 4 with 100% marrow infiltration to UMRD in 240 days. I have been on Acalabeutinib twice daily since, monthly bloods stable and 6 monthly unchained so still in Umrd.Keep safe.

[CLLCalifornia-USA]

Congratulations. May your health and happiness continue so you can follow your dreams. Sally

[KKwtx]

Wonderful news! Congrats!!

[laurieq]

Great news!!

[xpetes]

Congrats! What was the thinking behind stopping after 6 months though ? From what I understood even if you hit uMRD the treatment was supposed to be for 12 months. Please don't get me wrong, this is a great result, I'm more just curious since I didn't have the option to stop early and I was in the same situation as you.

[Golflover1954 in reply to xpetes]

My oncologist and I came to this decision together. There was a short term study called Gaussian that was 6 -9 months. Of the 44% who reached undetectable over 70% remain so after 5 years. I will be tested every 3 months clonoseq dna test. If my levels move rapidly toward the need for treatment, I will resume.

[xpetes in reply to Golflover1954]

Thanks so much for that info! My local onc. really wasn't keen on doing mrd testing as he relies on symptoms and CBC results. But I see a specialist annually at a big cancer center and that's how I got the Mrd testing. He offered me to do it every 6 months but I think I'm going to just do it annually as long as my CBC stays stable and normal.

Good luck to you in the future!

[Floxxy]

Fabulous x

[AnneHill]

Thata lovely news. The monitoring is something I havent heard of. I hope you feel well, Anne uk

[elm1]

I’m currently taking o plus v. My bloodwork was normal after the first infusion. I feel great and never had any symptoms. I would like to test for mrd after I complete the treatment. I had no idea you could do it before. Thanks for that information

[SUN5H1N3]

May I ask what your markers are? I just finished treatment and received a clear Bond marrow biopsy. I am 11q unmutated.

Thank you.