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An update on the other Abl Tyrosine Kinase Inhibition Phase 2 trial - PROSEEK by Sun Pharma Advanced Research Company (SPARC)
After almost 5 years, enrollment (N=506) is now complete! "The trial launched in 2019 and is expected to run through 2024." Note that the Study Record on the Clinical Trials website has yet to be updated with this latest information. It still gives a Recruitment Status of "Recruiting" and an Estimated
After almost 5 years, enrollment (N=506) is now complete! "The trial launched in 2019 and is expected to run through 2024." Note that the Study Record on the Clinical Trials website has yet to be updated with this latest information. It still gives a Recruitment Status of "Recruiting" and an Estimated
jeffreyn
in
Cure Parkinson's
11 months ago
A trial examining the effects of pausing BTKis to coincide with SARS-CoV-2 vaccination and its impact on immune responses in CLL patients
Trial registration number ISRCTN14197181 https://bmjopen.bmj.com/content/13/9/e077946 This study aims to determine in patients with chronic lymphocytic leukaemia (CLL) if a 3-week pause in Bruton
tyrosine
kinase inhibitor therapy (BTKi) starting 1 week before delivery of SARS-CoV-2 vaccine booster
Trial registration number ISRCTN14197181 https://bmjopen.bmj.com/content/13/9/e077946 This study aims to determine in patients with chronic lymphocytic leukaemia (CLL) if a 3-week pause in Bruton
tyrosine
kinase inhibitor therapy (BTKi) starting 1 week before delivery of SARS-CoV-2 vaccine booster
gardening-girl
in
CLL Support
1 year ago
Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders
., 20 mg/kg, 5 days before treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and for another 4 days) can suppress the MPTP-induced decline in rotarod time, pounds for grip strength, and forepaw stride length in mice, which was accompanied by an increase in
tyrosine
hydroxylase (TH)-positive
., 20 mg/kg, 5 days before treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and for another 4 days) can suppress the MPTP-induced decline in rotarod time, pounds for grip strength, and forepaw stride length in mice, which was accompanied by an increase in
tyrosine
hydroxylase (TH)-positive
Sydney75
in
Cure Parkinson's
10 months ago
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IBSA USA debuts three new dietary supplements - FilmTec B12.
Having produced Tirosint and Tirosint SOL levothyroxine (under their various names - brands and re-branded), IBSA appear to see supplements as a money-spinner. I'm just putting this here for information - hopefully at some point we will find out more. Like whether there is some basis for their absorption
Having produced Tirosint and Tirosint SOL levothyroxine (under their various names - brands and re-branded), IBSA appear to see supplements as a money-spinner. I'm just putting this here for information - hopefully at some point we will find out more. Like whether there is some basis for their absorption
helvella
in
Pernicious Anaemia Society
19 days ago
Does Clonazepam affect thyroid medication absorption?
I have suffered from chronic insomnia from the time I was given
Tyrosine
Kinase inhibitors for my CML. I tried to use every natural remedy possible to cure/reduce my insomnia. Sadly nothing worked. Now I sleep less than 3 hours some days. I am also suffering from micro sleep.
I have suffered from chronic insomnia from the time I was given
Tyrosine
Kinase inhibitors for my CML. I tried to use every natural remedy possible to cure/reduce my insomnia. Sadly nothing worked. Now I sleep less than 3 hours some days. I am also suffering from micro sleep.
Arkenstone
in
Thyroid UK
1 year ago
Tirosint - can anyone advise how I can find out if this brand is available in my area?
I am struggling to access lactose free Levothyroxine at my GP surgery’s pharmacy and have read that Tirosint has fewer excipients than most brands of T4 and wondered if anyone could advise me the best way forward for accessing this brand/or other similar brands? Many thanks.
I am struggling to access lactose free Levothyroxine at my GP surgery’s pharmacy and have read that Tirosint has fewer excipients than most brands of T4 and wondered if anyone could advise me the best way forward for accessing this brand/or other similar brands? Many thanks.
Mac2013
in
Thyroid UK
2 months ago
I GAVE UP.
I will try and be short about my story. It is a snapshot of events whilst I was on Levothyroxine for more or less 25 yrs. I never felt well and was never referred to an endocrinologist. I gained weight, my hair thinned. I had problems not only with my voice, but swallowing food. I had brain fog, acute
I will try and be short about my story. It is a snapshot of events whilst I was on Levothyroxine for more or less 25 yrs. I never felt well and was never referred to an endocrinologist. I gained weight, my hair thinned. I had problems not only with my voice, but swallowing food. I had brain fog, acute
Whiterose15
in
Thyroid UK
2 months ago
blood results
hi everyone, so I’m on tirosint 100 T4 and 15 mg of T3 these are my blood results TSH. 0.03 FT4 1.4 FT3. 3.4 TPO. 1 I’m not good. Have all these symptoms from vertigo , panic attack pain. I’m so confused those anyone have any suggestions thank you. 🙏
hi everyone, so I’m on tirosint 100 T4 and 15 mg of T3 these are my blood results TSH. 0.03 FT4 1.4 FT3. 3.4 TPO. 1 I’m not good. Have all these symptoms from vertigo , panic attack pain. I’m so confused those anyone have any suggestions thank you. 🙏
edleenia
in
Thyroid UK
2 months ago
Tirosint
Hi all, Has anyone in the UK managed to get Tirosint on the NHS? My NHS endocrinologist and GP were prepared to continue prescribing it after my private endocrinologist put me on it, but it's not listed on my county's formulary, so their hands are now tied. They have, however, said they are happy
Hi all, Has anyone in the UK managed to get Tirosint on the NHS? My NHS endocrinologist and GP were prepared to continue prescribing it after my private endocrinologist put me on it, but it's not listed on my county's formulary, so their hands are now tied. They have, however, said they are happy
Nibs94
in
Thyroid UK
2 months ago
T3 and cortisol issues?
hello, I could really use some help piecing my mess together. I’ll try to be brief but that may be difficult because there’s a lot to unpack. 2009 thyroidectomy for large goiter and hashimotos Lived comfortably on 150/175 mcgs of Levo until perimenopause. Around that time i developed severe anxiety
hello, I could really use some help piecing my mess together. I’ll try to be brief but that may be difficult because there’s a lot to unpack. 2009 thyroidectomy for large goiter and hashimotos Lived comfortably on 150/175 mcgs of Levo until perimenopause. Around that time i developed severe anxiety
Knittergirl3
in
Thyroid UK
2 months ago
T3 Advice
I have been on 112 Tirosint for 3 months. I am apathetic, irritable, sleeping a lot and have crazy muscle pains. Based on below labs, I convinced my doc to add in T3. She dropped Tirosint to 100 and said add 5mcg of liothyronine. Should I give it a couple weeks on just 100 before adding in t3? Should
I have been on 112 Tirosint for 3 months. I am apathetic, irritable, sleeping a lot and have crazy muscle pains. Based on below labs, I convinced my doc to add in T3. She dropped Tirosint to 100 and said add 5mcg of liothyronine. Should I give it a couple weeks on just 100 before adding in t3? Should
Fmljkl
in
Thyroid UK
3 months ago
Results on 75mcg T4
Dear members, I am lost,I need help. I have hashi and hypo. 6 weeks ago I switched medications from 50mcg for 7 days Tirosint to 75mcg Tirosint for 5 days and 2 days 50 mcg. My results on 50mcg/7 days TSH 0.036 (0.27-4.20) FT3 3.75 ( 3.1-6.8) FT4 16.80 (12-22) My results on 75mcg/5 days/50mcg 2 days
Dear members, I am lost,I need help. I have hashi and hypo. 6 weeks ago I switched medications from 50mcg for 7 days Tirosint to 75mcg Tirosint for 5 days and 2 days 50 mcg. My results on 50mcg/7 days TSH 0.036 (0.27-4.20) FT3 3.75 ( 3.1-6.8) FT4 16.80 (12-22) My results on 75mcg/5 days/50mcg 2 days
MartinaM
in
Thyroid UK
3 months ago
what to do now ?
Hi All Confused what to do next ? These are my results after 6 weeks on new regime Bloods taken 8am and 12 hours after last dose of T3 125 mcg Tirosint 2.5 mcg T3 I’m feeling much warmer and brain fog is better although I do feel a little angst and teary at times ? Energy is much better.
Hi All Confused what to do next ? These are my results after 6 weeks on new regime Bloods taken 8am and 12 hours after last dose of T3 125 mcg Tirosint 2.5 mcg T3 I’m feeling much warmer and brain fog is better although I do feel a little angst and teary at times ? Energy is much better.
joskie
in
Thyroid UK
3 months ago
Tirosint - any experience
Hi I’m on holiday in Greece. I usually buy my levothyroxine (hate being reliant on brand lottery with NHS prescription). I usually get Unipharma. The Greek pharmacist suggested Tirosint as it contains no additives but it’s 8 rather than 2 euros for a months supply. Has anybody used it and if so does
Hi I’m on holiday in Greece. I usually buy my levothyroxine (hate being reliant on brand lottery with NHS prescription). I usually get Unipharma. The Greek pharmacist suggested Tirosint as it contains no additives but it’s 8 rather than 2 euros for a months supply. Has anybody used it and if so does
Hashiboy
in
Thyroid UK
3 months ago
Generic Tirosint - Levothyroxine Sodium capsules USP made by Lannett - has anyone in the UK managed to obtain this medicine?
I would like to try Tirosint - to combine it with a trial of Liothyronine - I believe Tirosint is available from Roseway Labs on private prescription. But it's very expensive. I had heard that there was a generic version made in the US by Lannett Company Inc. Does anyone have any information about
I would like to try Tirosint - to combine it with a trial of Liothyronine - I believe Tirosint is available from Roseway Labs on private prescription. But it's very expensive. I had heard that there was a generic version made in the US by Lannett Company Inc. Does anyone have any information about
origami
in
Thyroid UK
4 months ago
Multiple mechanisms to clear a-synuclein with natural substances (in mice).
It also rescued
tyrosine
hydroxylase and dopamine transporter expression in the striatum, and decreased a-synuclein aggregation following 6-OHDA treatment in vivo. 11 The validated mechanism of ECH activity was the reduction in the 6-OHDA-induced accumulation of seipin.
It also rescued
tyrosine
hydroxylase and dopamine transporter expression in the striatum, and decreased a-synuclein aggregation following 6-OHDA treatment in vivo. 11 The validated mechanism of ECH activity was the reduction in the 6-OHDA-induced accumulation of seipin.
House2
in
Cure Parkinson's
11 months ago
New Labs
Sorry it has been years since able to get on my technology. Finally feeling better. These are my latest results any suggestions. Currently taking Tirosint 75mcg. May 15,2024 TSH 3rd generation 1.710 (.4-4.5 uIU/ML) T3 Reverse. 16.5 (9.0-27.0mg/dl) T3 Free 2.40 (2.40-6.80 pg/ml) T3
Sorry it has been years since able to get on my technology. Finally feeling better. These are my latest results any suggestions. Currently taking Tirosint 75mcg. May 15,2024 TSH 3rd generation 1.710 (.4-4.5 uIU/ML) T3 Reverse. 16.5 (9.0-27.0mg/dl) T3 Free 2.40 (2.40-6.80 pg/ml) T3
Thyroid66
in
Thyroid UK
4 months ago
Hashimoto and Weight Loss?
Who among you in hypothyroidism is being treated with the drug (
tyrosine
or eutirox... I live in Europe). Have you managed to lose weight while taking the drug? And not to gain weight again? Thank you ✨ ps: English is not my first language. 🙂
Who among you in hypothyroidism is being treated with the drug (
tyrosine
or eutirox... I live in Europe). Have you managed to lose weight while taking the drug? And not to gain weight again? Thank you ✨ ps: English is not my first language. 🙂
darkacademia
in
Thyroid UK
10 months ago
Help with my test results please
Hi All I would like help with my latest blood tests results PLEASE and guidance of what to do next ??? I have Autoimmune Hashimotos 27 years ! So to keep this short I’ve recently ( past 3 months ) changed from Armour Thyroid ( took for 5 years ) to Tirosint ( I’m lactose intolerant ) previous
Hi All I would like help with my latest blood tests results PLEASE and guidance of what to do next ??? I have Autoimmune Hashimotos 27 years ! So to keep this short I’ve recently ( past 3 months ) changed from Armour Thyroid ( took for 5 years ) to Tirosint ( I’m lactose intolerant ) previous
joskie
in
Thyroid UK
4 months ago
Efficacy and safety of new‑generation BTKis (primarily acalabrutinib and zanubrutinib) in CLL/SLL: a systematic review and meta‑analysis
[/i] The full study title is
Efficacy and safety of new‑generation Bruton
kinase inhibitors in chronic lymphocytic leukemia/small lymphocytic lymphoma: a systematic review and meta‑analysis The authors are from the Department of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital
[/i] The full study title is
Efficacy and safety of new‑generation Bruton
kinase inhibitors in chronic lymphocytic leukemia/small lymphocytic lymphoma: a systematic review and meta‑analysis The authors are from the Department of Neuro-Oncology, Cancer Center, Beijing Tiantan Hospital
AussieNeil
Partner
in
CLL Support
11 months ago
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