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CAR-T for CLL Hits Goal of Mid-Stage Trial - All patients had progressed on BTK inhibitors & most had failed venetoclax - MedPageToday, 6/12
[/i] [i]These 49 patients had progressed on previous Bruton
tyrosine
kinase (BTK) inhibitors and experienced venetoclax (Venclexta) failure, making them "double refractory," and had been treated at the recommended phase II dose level of 100×10⁶ CAR-positive T cells, they noted in The Lancet.
[/i] [i]These 49 patients had progressed on previous Bruton
tyrosine
kinase (BTK) inhibitors and experienced venetoclax (Venclexta) failure, making them "double refractory," and had been treated at the recommended phase II dose level of 100×10⁶ CAR-positive T cells, they noted in The Lancet.
cujoe
in
CLL Support
11 months ago
latest results & pericaridal effusion
currently on 75mcg of tirosint 6 days a week and 1 day 100mcg, also on NDT 1 1/4 grain. I do feel awful at the moment most days with extreme fatigue, hair loss, muscle weakness and spasms, pain. I have had terrible heart problems I already have PoTs but for the past year I have had pericardial
currently on 75mcg of tirosint 6 days a week and 1 day 100mcg, also on NDT 1 1/4 grain. I do feel awful at the moment most days with extreme fatigue, hair loss, muscle weakness and spasms, pain. I have had terrible heart problems I already have PoTs but for the past year I have had pericardial
Ajva
in
Thyroid UK
3 months ago
alergig to euthyrox
i want to find on lene to buy tirosint 50mg can you advice from wher . i started lt4 and i am geting very ill rash and dizzy also diarhea headaches ii been taking it one month and i feel more ill than beter i am on 50mg per day .
i want to find on lene to buy tirosint 50mg can you advice from wher . i started lt4 and i am geting very ill rash and dizzy also diarhea headaches ii been taking it one month and i feel more ill than beter i am on 50mg per day .
morcan54
in
Thyroid UK
3 months ago
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Tirosint
Hi Everyone, I have been taking a different Tirosint from Germany for the last 6 months. In a gelatine coating. I have had a severe rash all over my body and didn’t think for one minute it was from this. Anyone else experience this? Also, where can I get an alternative in the UK ? Thanks 🙏
Hi Everyone, I have been taking a different Tirosint from Germany for the last 6 months. In a gelatine coating. I have had a severe rash all over my body and didn’t think for one minute it was from this. Anyone else experience this? Also, where can I get an alternative in the UK ? Thanks 🙏
jand123
in
Thyroid UK
3 months ago
New Thyroid Results - Conversion Issue?
Hi, After an emotional Thyroid rollercoaster these past couple years (post partial thyroidectomy 12/2/21 in combination with an Endo who doesn't believe in compounded medication), I finally seem to be settling into a medication and dose that works okay. I'd have to say that I'm still a bit tired and
Hi, After an emotional Thyroid rollercoaster these past couple years (post partial thyroidectomy 12/2/21 in combination with an Endo who doesn't believe in compounded medication), I finally seem to be settling into a medication and dose that works okay. I'd have to say that I'm still a bit tired and
KarmaMaya
in
Thyroid UK
3 months ago
Really struggling
I have not been able to take thyroxine when I was diagnosed in March 2021, ended up on low FODMAP and with a homeopath and naturopath but went from 9 st 5 to 7 stone 11 when doctors got concerned. Every time I tried to include a food back in diet I was worse. Started thyroxine liquid in September 2023
I have not been able to take thyroxine when I was diagnosed in March 2021, ended up on low FODMAP and with a homeopath and naturopath but went from 9 st 5 to 7 stone 11 when doctors got concerned. Every time I tried to include a food back in diet I was worse. Started thyroxine liquid in September 2023
Da52
in
Thyroid UK
4 months ago
Tirosint Brand levothyroxin
Hello everyone and hope you have had wonderful holiday so far. Is there anyone here with experience of Tirosint Brand of Levothyroxin? I would be truly grateful to hear your opinions and comments about it. Have a lovely rest of the holiday.
Hello everyone and hope you have had wonderful holiday so far. Is there anyone here with experience of Tirosint Brand of Levothyroxin? I would be truly grateful to hear your opinions and comments about it. Have a lovely rest of the holiday.
Happy2828
in
Thyroid UK
4 months ago
Tirosint
I am unable to take tablet form levothyroxine, I have a gene issue with metabolising some medications. I have started liquid thyroxine but I think the ingredients are affecting my stomach and I have been told to stop taking this to see if it is the cause. I see that Tirosint is quite pure but not sure
I am unable to take tablet form levothyroxine, I have a gene issue with metabolising some medications. I have started liquid thyroxine but I think the ingredients are affecting my stomach and I have been told to stop taking this to see if it is the cause. I see that Tirosint is quite pure but not sure
Da52
in
Thyroid UK
4 months ago
TRT + Hypothyroidism Issue
Hello, I've been on Thyroid meds for a few years, everything was stable until I started taking TRT along with the thyroid medication. My latest labs are FT3 - 3.42 pg/ml / Range 2.02-4.43 FT4 - 1.15 ng/dl /Range 0.93.170 TSH - 0.97 /Range 0.27-4.20 Testosterone - 480ng/ml / Range: - 249-839
Hello, I've been on Thyroid meds for a few years, everything was stable until I started taking TRT along with the thyroid medication. My latest labs are FT3 - 3.42 pg/ml / Range 2.02-4.43 FT4 - 1.15 ng/dl /Range 0.93.170 TSH - 0.97 /Range 0.27-4.20 Testosterone - 480ng/ml / Range: - 249-839
greg233
in
Thyroid UK
5 months ago
Tirosint
Dear all I have been reading posts on and off since I "joined" this forum, and see that a lot of good advice and support has been given. But have never taken taken the plunge in asking for help and advice, so here goes. I was finally diagnosed with Graves disease in 2018, given radio iodine therapy a
Dear all I have been reading posts on and off since I "joined" this forum, and see that a lot of good advice and support has been given. But have never taken taken the plunge in asking for help and advice, so here goes. I was finally diagnosed with Graves disease in 2018, given radio iodine therapy a
Rara8
in
Thyroid UK
5 months ago
Tirosint
Its been 10.5 months since my thyroidectomy. I was at .69 TSH on levothyroxine 100 mgs a day with mega side effects. Doctors just switched me Tirosint 88 mgs a day. Am I to expect more serious changes, again. I lost my voice, got chubby, lost hair, aged, and more. Its been a life-changing experience
Its been 10.5 months since my thyroidectomy. I was at .69 TSH on levothyroxine 100 mgs a day with mega side effects. Doctors just switched me Tirosint 88 mgs a day. Am I to expect more serious changes, again. I lost my voice, got chubby, lost hair, aged, and more. Its been a life-changing experience
AuthorJAR
in
Thyroid UK
5 months ago
BTK Degrader Shows Potential for Treating Refractory CLL and SLL
A novel Bruton's
tyrosine
kinase (BTK) degrader, NX-2127, has shown potential for treating patients with double- and triple-refractory CLL or SLL who have experienced disease progression while on any covalent or non-covalent BTK inhibitor, as well as a BCL2 inhibitor.
A novel Bruton's
tyrosine
kinase (BTK) degrader, NX-2127, has shown potential for treating patients with double- and triple-refractory CLL or SLL who have experienced disease progression while on any covalent or non-covalent BTK inhibitor, as well as a BCL2 inhibitor.
Jm954
Administrator
in
CLL Support
1 year ago
Tyrosines d RLS
I’ve been reading g about
Tyrosine
deficits in TLS. My question is if it converttoL-Dooa and then to Dooamine, could it cause augmentation? Has anyone out there have any experience with
Tyrosine
?
I’ve been reading g about
Tyrosine
deficits in TLS. My question is if it converttoL-Dooa and then to Dooamine, could it cause augmentation? Has anyone out there have any experience with
Tyrosine
?
Hidden
in
Restless Legs Syndrome
1 year ago
Bariatric surgery, what do you think?
I've been thinking about doing a stomach reduction surgery (gastric sleeve) because I can't lose weight. Since I have problems with my thyroid (RAI ablation in 2012) I gained 25 kg(90 kg in the past and now I've 115/1,87 cm)), I have tried all the treatments(ndt, synthetic) that have not yielded results
I've been thinking about doing a stomach reduction surgery (gastric sleeve) because I can't lose weight. Since I have problems with my thyroid (RAI ablation in 2012) I gained 25 kg(90 kg in the past and now I've 115/1,87 cm)), I have tried all the treatments(ndt, synthetic) that have not yielded results
adin
in
Thyroid UK
6 months ago
Total t3 and free t3
Hi all-Just would like to know how important the total t3 is on a fasting blood test. The weird thing is, my free t3 has gone up, now in the mid range which is good,it's never been so high.. but my total t3 is at the very bottom range, while my tsh is now below range, near suppressed. T4 is good, above
Hi all-Just would like to know how important the total t3 is on a fasting blood test. The weird thing is, my free t3 has gone up, now in the mid range which is good,it's never been so high.. but my total t3 is at the very bottom range, while my tsh is now below range, near suppressed. T4 is good, above
abartme
in
Thyroid UK
7 months ago
Success with Adderall dependence and changing medications?
(L-Phenylalanine or L-
Tyrosine
or L-Dopa ), L-Tryptophan or 5-HTP, L-Theanine I can say personally that DHT and EPT Omega-3 i.e. found in fish oil does help improve effects of ADHD meds in general.
(L-Phenylalanine or L-
Tyrosine
or L-Dopa ), L-Tryptophan or 5-HTP, L-Theanine I can say personally that DHT and EPT Omega-3 i.e. found in fish oil does help improve effects of ADHD meds in general.
HCStymie
in
CHADD's Adult ADHD Support
1 year ago
lower t4 super low tsh armour
Hello! I am 20 years deep at age 40 into basically helping doctors regulate my thyroid after a horrible medical overdose at age 17 my thyroid was never the same ….perhaps it was like that as a kid from a traumatic move because I gained 40 pounds seemingly overnight, however I didn’t become medicated
Hello! I am 20 years deep at age 40 into basically helping doctors regulate my thyroid after a horrible medical overdose at age 17 my thyroid was never the same ….perhaps it was like that as a kid from a traumatic move because I gained 40 pounds seemingly overnight, however I didn’t become medicated
DeedellaD
in
Thyroid UK
8 months ago
Benfotiamine (Fat Soluble Form Of Vitamin B1) and AD
Two dozen biomarker candidates including thiamine,
tyrosine
, tryptophan, lysine, and 22 lipid species, mostly belonging to phosphatidylcholines reflected reversal of changes related to AD progression.
Two dozen biomarker candidates including thiamine,
tyrosine
, tryptophan, lysine, and 22 lipid species, mostly belonging to phosphatidylcholines reflected reversal of changes related to AD progression.
chartist
in
Cure Parkinson's
1 year ago
Time before meals/ T3+T4 Blood tests
Hello, For the past 2 months, I've been on T4 Tirsoint Sol 75 + T3 Thybon 10mcg. My recent blood tests have been great. TSH - 1.07 ulU/ml - 0.27-4.20 FT4 - 1.45 ng/dl - 0.93-1.70 FT3 - 3.31 pg/ml -2.02-4.43 I've been feeling a bit sluggish lately and cold especially in the arms and legs, going
Hello, For the past 2 months, I've been on T4 Tirsoint Sol 75 + T3 Thybon 10mcg. My recent blood tests have been great. TSH - 1.07 ulU/ml - 0.27-4.20 FT4 - 1.45 ng/dl - 0.93-1.70 FT3 - 3.31 pg/ml -2.02-4.43 I've been feeling a bit sluggish lately and cold especially in the arms and legs, going
cezary97
in
Thyroid UK
8 months ago
St. John’s wort, ursolic acid, Gardenia jasminoides
Enzymes involved in the synthesis of dopamine from
tyrosine
, namely tyrosinase and
tyrosine
decarboxylase, are not influenced by hypericin at concentrations from 1 up to 10 µmol/l.”
Enzymes involved in the synthesis of dopamine from
tyrosine
, namely tyrosinase and
tyrosine
decarboxylase, are not influenced by hypericin at concentrations from 1 up to 10 µmol/l.”
LAJ12345
in
Cure Parkinson's
1 year ago
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