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Clinical trials as a treatment option
When my mother was diagnosed with stage 3 cancer, I looked for clinical trials she could enter. I have worked in drug development for 12 years and yet it took me 6 hours to find the three most suitable clinical trials for her. In the next medical appointment, I presented those three trials to the oncologist
When my mother was diagnosed with stage 3 cancer, I looked for clinical trials she could enter. I have worked in drug development for 12 years and yet it took me 6 hours to find the three most suitable clinical trials for her. In the next medical appointment, I presented those three trials to the oncologist
N1ria
in
The Roy Castle Lung Cancer Foundation
10 months ago
Senescent neutrophils and their subsequent impact on tumor progression and therapy resistance
I will comment after studying this for awhile, but it does open up an additional treatment path(s?) for PCa. (Excerpts) Calcinotto's team discovered that prostate tumor cells produce a molecule, ApoE, which can bind to and influence a type of immune cells, neutrophils, resulting in these cells acquiring
I will comment after studying this for awhile, but it does open up an additional treatment path(s?) for PCa. (Excerpts) Calcinotto's team discovered that prostate tumor cells produce a molecule, ApoE, which can bind to and influence a type of immune cells, neutrophils, resulting in these cells acquiring
cigafred
in
Fight Prostate Cancer
10 months ago
An update on Peter Mac and Lu-177
I just wanted to update on my previous post (https://healthunlocked.com/advanced-prostate-cancer/posts/149757852/update-on-failing-enzalutamide). I have now heard from Michael Hoffman at Peter Mac and his response to my request to be considered was as follows: [i]"Our Lu-177 treatment guidelines require
I just wanted to update on my previous post (https://healthunlocked.com/advanced-prostate-cancer/posts/149757852/update-on-failing-enzalutamide). I have now heard from Michael Hoffman at Peter Mac and his response to my request to be considered was as follows: [i]"Our Lu-177 treatment guidelines require
CrocodileShoes
in
Advanced Prostate Cancer
10 months ago
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Update on failing Enzalutamide
Hello again friends, I wrote recently after learning that Xtandi was no longer working, seeking options. Since then I have had a consultation with my Oncologist and we went through the (limited) range of options for someone who is living in the UK and being treated on the National Health Service. Brief
Hello again friends, I wrote recently after learning that Xtandi was no longer working, seeking options. Since then I have had a consultation with my Oncologist and we went through the (limited) range of options for someone who is living in the UK and being treated on the National Health Service. Brief
CrocodileShoes
in
Advanced Prostate Cancer
10 months ago
Ruxolitinib
Hi all, I have PV and AB is high , around 81% , spleen size slightly increased but if I didn’t know I have PV I would think I am the healthiest person around as I have no symptoms. I was diagnosed end of 2018 but had it al least since 2015. I am considering taking a part in clinical trial for Ruxo and
Hi all, I have PV and AB is high , around 81% , spleen size slightly increased but if I didn’t know I have PV I would think I am the healthiest person around as I have no symptoms. I was diagnosed end of 2018 but had it al least since 2015. I am considering taking a part in clinical trial for Ruxo and
Ameliav
in
MPN Voice
10 months ago
I fired my oncologist
Almost a year ago I had radiation and started Lupron, Prednesone, and Abiraterone which immediately brought my PSA and T levels to undetectable. I also enrolled in a clinical trial of an experimental immunotherapy drug SD-101 along with infusions of Keytruda (pembrolizumab). I became extremely depressed
Almost a year ago I had radiation and started Lupron, Prednesone, and Abiraterone which immediately brought my PSA and T levels to undetectable. I also enrolled in a clinical trial of an experimental immunotherapy drug SD-101 along with infusions of Keytruda (pembrolizumab). I became extremely depressed
cageycruz
in
Advanced Prostate Cancer
10 months ago
Inhibikase IkT-148009 Phase 2: the study record on the Clinical Trials website has had a small, but significant, update.
The Estimated Study Completion Date is now January 1, 2025. They have been recruiting for a couple of months. Enrolment activity during that time would have had some influence on the estimation of the new completion date. According to the study record, they are seeking 90 untreated PwPs, with each
The Estimated Study Completion Date is now January 1, 2025. They have been recruiting for a couple of months. Enrolment activity during that time would have had some influence on the estimation of the new completion date. According to the study record, they are seeking 90 untreated PwPs, with each
jeffreyn
in
Cure Parkinson's
10 months ago
ART Vit D and Prostate Cancer (PCa) by Dr Campbell UK Podcast
Dr Campbell, UK, has made a summary of recent investigations and studies on VIT D and its effect on PCa specifically and cancer generally. Of import is his discussiono on the finding on PCa and African Americans; they have a genomic risk factor that leads to more aggressive PCa, BUT respond quickly
Dr Campbell, UK, has made a summary of recent investigations and studies on VIT D and its effect on PCa specifically and cancer generally. Of import is his discussiono on the finding on PCa and African Americans; they have a genomic risk factor that leads to more aggressive PCa, BUT respond quickly
RMontana
in
Active Surveillance - Prostate Cancer
10 months ago
Fecal Microbiota Transplantation (FMT) For PD And Much Much More
While many of us are aware of the potential that FMT has shown for PD, Clostridium difficile (C. diff) and IBS that has not responded to standard therapy, I wrote this to highlight the fact that FMT has shown the potential to also help a multitude of other diseases and health issues that are often seen
While many of us are aware of the potential that FMT has shown for PD, Clostridium difficile (C. diff) and IBS that has not responded to standard therapy, I wrote this to highlight the fact that FMT has shown the potential to also help a multitude of other diseases and health issues that are often seen
chartist
in
Cure Parkinson's
10 months ago
2nd Opinion.
Hello everyone. As a few of you will know I have done all the treatments possible including Pluvicto which failed. My MO has put me on Jevtana for which I have comepleted 2 treatments so far. After my call today with my doctor it was evident he is losing hope for me ( understood) and he will look
Hello everyone. As a few of you will know I have done all the treatments possible including Pluvicto which failed. My MO has put me on Jevtana for which I have comepleted 2 treatments so far. After my call today with my doctor it was evident he is losing hope for me ( understood) and he will look
db1966
in
Advanced Prostate Cancer
10 months ago
Micronized Progesterone - Does it do anything?
I started taking HRT a while ago and I felt was all over the place, sometimes on top of the world. sometimes awful - it took me a lot longer than it ought to have done to figure out that in the 2 weeks that I take Oestrogen only I'm amazing, and when I take Utrogestan with Oestrogen I can barely function
I started taking HRT a while ago and I felt was all over the place, sometimes on top of the world. sometimes awful - it took me a lot longer than it ought to have done to figure out that in the 2 weeks that I take Oestrogen only I'm amazing, and when I take Utrogestan with Oestrogen I can barely function
Abra_ka_dabra
in
Menopause and Perimenopause Support
10 months ago
INCA033989 phase 1 clinical trial is recruiting patients
[i]Source: https://www.rarediseaseadvisor.com/news/mf-news-briefs/phase-1-trial-testing-potential-mf-therapy-recruiting/[/i] A new phase 1 clinical trial evaluating the safety, tolerability, and dose limiting toxicity of INCA033989 as a monotherapy or in combination with ruxolitinib in patients with
[i]Source: https://www.rarediseaseadvisor.com/news/mf-news-briefs/phase-1-trial-testing-potential-mf-therapy-recruiting/[/i] A new phase 1 clinical trial evaluating the safety, tolerability, and dose limiting toxicity of INCA033989 as a monotherapy or in combination with ruxolitinib in patients with
flamboyant_hawking
in
MPN Voice
10 months ago
Treatment Options
Hi, Looking for some help with options presented by my MO. Below are my latest PSA results PSA TOTAL. 0.77. 07/10/2023 PSA TOTAL 0.67. 06/20/2023 PSA TOTAL 0.17. 03/21/2023 PSA TOTAL. 0.38. 12/20/2022 PSA TOTAL. 0.67. 11/15/2022 PSA TOTAL. 0.64. 10/25/2022 Been
Hi, Looking for some help with options presented by my MO. Below are my latest PSA results PSA TOTAL. 0.77. 07/10/2023 PSA TOTAL 0.67. 06/20/2023 PSA TOTAL 0.17. 03/21/2023 PSA TOTAL. 0.38. 12/20/2022 PSA TOTAL. 0.67. 11/15/2022 PSA TOTAL. 0.64. 10/25/2022 Been
Coachmy4
in
Advanced Prostate Cancer
10 months ago
A Drug To Prevent Suicide Associated With BiPolar Depression
Suicidal bipolar depression accounts for 40% of people who try to harm themselves, yet there’s never been an FDA-approved drug for this indication. Every second of every day, someone in the world attempts suicide. NRx Pharmaceuticals is developing a drug for people whose suicidal thoughts stem
Suicidal bipolar depression accounts for 40% of people who try to harm themselves, yet there’s never been an FDA-approved drug for this indication. Every second of every day, someone in the world attempts suicide. NRx Pharmaceuticals is developing a drug for people whose suicidal thoughts stem
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
10 months ago
PSA down but mets increasing?
I've been on ADT + Xtandi for about a year (see my Bio for details) and my PSA has been slowly and steadily reducing over that time - now down to 0.05. However, my 3 CT scans (last August, December and last month) are showing a slight increase each time in the size of my lymph node mets and the bone
I've been on ADT + Xtandi for about a year (see my Bio for details) and my PSA has been slowly and steadily reducing over that time - now down to 0.05. However, my 3 CT scans (last August, December and last month) are showing a slight increase each time in the size of my lymph node mets and the bone
Benkaymel
in
Advanced Prostate Cancer
11 months ago
At a crossroads
Greetings All, I have recently been scanned and increased Mets in bones and a new small spot in my liver have been found, eliminating me from my Phase Ib clinical trial that had worked from November 2021. My earlier first line of treatment, Ibrance Fulvestrant failed after about 8 months. I am now
Greetings All, I have recently been scanned and increased Mets in bones and a new small spot in my liver have been found, eliminating me from my Phase Ib clinical trial that had worked from November 2021. My earlier first line of treatment, Ibrance Fulvestrant failed after about 8 months. I am now
Garlicgrower
in
SHARE Metastatic Breast Cancer
11 months ago
Next Steps?
Good morning my fellow warriors. I have reached another cross roads in my treatment. I was set up to have HDR and SbRT as salvage treatment, but a PSMA scan showed disease progression to more lymph nodes which caused my Radiation Onc. to cancel the HDR. My regular ONC is now recommending Chemo after
Good morning my fellow warriors. I have reached another cross roads in my treatment. I was set up to have HDR and SbRT as salvage treatment, but a PSMA scan showed disease progression to more lymph nodes which caused my Radiation Onc. to cancel the HDR. My regular ONC is now recommending Chemo after
wat380bjw
in
Advanced Prostate Cancer
11 months ago
supplemental pbc treatments
Does anyone have diet and supplement experience and advice to help bring fibroses down? Resist temptation to say you don’t know any other than Ursodoil, obeticholic acid, Fenofibrate and clinical trial Setanix I’m looking for supplemental treatments to practice along with these treatments western
Does anyone have diet and supplement experience and advice to help bring fibroses down? Resist temptation to say you don’t know any other than Ursodoil, obeticholic acid, Fenofibrate and clinical trial Setanix I’m looking for supplemental treatments to practice along with these treatments western
Jlruggie
in
PBC Foundation
11 months ago
Venetoclax for dummies
Venetoclax owes its origin to a lady named Eliza Hall, I bet AussieNeil has heard of her. Eliza was a lady from Melbourne Australia who married an Englishman named Walter Hall in 1874. Walter Hall and his two brothers arrived almost penniless in Australia in 1852, coming from England to search for
Venetoclax owes its origin to a lady named Eliza Hall, I bet AussieNeil has heard of her. Eliza was a lady from Melbourne Australia who married an Englishman named Walter Hall in 1874. Walter Hall and his two brothers arrived almost penniless in Australia in 1852, coming from England to search for
cajunjeff
in
CLL Support
11 months ago
Aspirin Warning: Anemia May Increase With Use
»Older people who take daily low-dose aspirin have at 20% higher risk of developing anemia even without having already had a major bleeding event, according to results from a new randomized controlled trial. In the study, which was published June 20 in the Annals of Internal Medicine, investigators
»Older people who take daily low-dose aspirin have at 20% higher risk of developing anemia even without having already had a major bleeding event, according to results from a new randomized controlled trial. In the study, which was published June 20 in the Annals of Internal Medicine, investigators
Manouche
in
MPN Voice
11 months ago
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