And again news about clinical trials - Advanced Prostate...

Advanced Prostate Cancer

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And again news about clinical trials

Maxone73 profile image
23 Replies

Clinical trial tests creatine monohydrate and exercise to preserve muscle mass in prostate cancer

news-medical.net/news/20231...

(hint: been a natural bodybuilder from 1991 to 2009 with (almost) 20" biceps and all...restarted working out "seriously" in 2019...for all my "career" I barely noticed any difference taking protein supplements, never noticed ANY difference with creatine when I was younger...but maybe it was bad luck!)

Novel Drug-Immunotherapy Combo Boosts Survival in Rare Prostate Cancer - Cure Today

tabout his I already posted something yesterday: curetoday.com/view/novel-dr...

PDS Biotech Announces Interim Safety and Immune Response Data from Phase 1/2 Clinical ...

finance.yahoo.com/news/pds-...

Ok...doesn't look good being on Yahoo Finance, but we are still talking big and medium Pharma :-P

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Maxone73 profile image
Maxone73
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Derf4223 profile image
Derf4223

Helps bone density too google.com/search?q=creatin...

PCaWarrior profile image
PCaWarrior

1. Mouse study: Inhibition of rate of tumor growth by creatine and cyclocreatine. - PMC

ncbi.nlm.nih.gov/labs/pmc/a...

2. Mouse study: Creatine powers T cells’ fight against cancer | UCLA

newsroom.ucla.edu/releases/...

3. Mouse study: Creatine in T Cell Antitumor Immunity and Cancer Immunotherapy – PMC

ncbi.nlm.nih.gov/pmc/articl...

4. The two sides of creatine in cancer – ScienceDirect

sciencedirect.com/science/a...

5. Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review – PMC

ncbi.nlm.nih.gov/pmc/articl...

6. Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review) – PubMed

pubmed.ncbi.nlm.nih.gov/232...

7. Mouse study: Creatine promotes cancer metastasis through activation of Smad2/3

cell.com/cell-metabolism/pd...

8. Creatine uptake regulates CD8 T cell antitumor immunity | Journal of Experimental Medicine | Rockefeller

rupress.org/jem/article/216...

Exercise is SOC for PCa.

20"? Impressive. At my peak mine were 19". That was 40 years ago.

Maxone73 profile image
Maxone73 in reply to PCaWarrior

Eh, I am "only" 50! Are those papers all in vitro/ in vivo or is there something clinical?

PCaWarrior profile image
PCaWarrior in reply to Maxone73

I was 20 at my peak. I had to buckle down in school. So bodybuilding went bye bye. Never got it all back.

Maxone73 profile image
Maxone73 in reply to PCaWarrior

I was at my peak strength at 27-28, at my peak as hypertrophy at around 30-33, also because I always worked out more as a weightlifter/powerlifter rather than bodybuilder. And basically most of my joints hate me for that!! Now when they ask me for some advice, the first thing I say is "don't constantly lift heavy stuff!! nothing wrong in reaching 10 reps" LOL

PCaWarrior profile image
PCaWarrior in reply to Maxone73

I never had to warmup until I was in my 50s. I'm writing this while I'm heating up/massaging my joints in preparation for a workout.

Warmups, ice, heat, massage, sauna, take almost an hour a day.

Maxone73 profile image
Maxone73 in reply to PCaWarrior

Because of PC or because your joints hate you as well? I also have to warm-up carefully nowadays and I added some stretching at the end.

PCaWarrior profile image
PCaWarrior in reply to Maxone73

PCa. Part of the time I'm in a low androgen state and my joints start wearing down.

You'd think that when androgens are plentiful they would bounce back. But, much like a woman, they never forget and forgiveness is not an option.

PCaWarrior profile image
PCaWarrior in reply to Maxone73

No clinical evidence that I know of.

There are plenty of trials for exercise but not for creatine/PCa.

Maxone73 profile image
Maxone73 in reply to PCaWarrior

When I read something like this I do not feel very comfy!! :-P

"Creatine and its analog, cyclocreatine, have been considered cancer suppressive metabolites due to their effects on suppression of subcutaneous cancer growth. Recently, emerging studies have demonstrated the promoting effect of creatine on cancer metastasis."

PCaWarrior profile image
PCaWarrior in reply to Maxone73

I post the good with the bad. I have no agenda.

The balance of good evidence supports using things that help your muscle mass, energy, and strength while helping to counter fat. As you know, vegetarians are usually low on creatine. Creatine might help this population if they strength train.

Maxone73 profile image
Maxone73 in reply to PCaWarrior

I became vegan since diagnosis, so I may need to think about creatine. But honestly I have not (yet) seen a dramatic decrease of strength and resistance. Ok, I have been on ADT for 2 months only basically.

Benkaymel profile image
Benkaymel in reply to Maxone73

Two months is not long enough to notice any change. It was at between 6 and 9 months that I really started to feel weaker.

Maxone73 profile image
Maxone73 in reply to Benkaymel

I am practically placing training equipment in every room (except bathrooms)...I have always worked out or done sports so it's something I love to do, I just hope I will determined enough!

PCaWarrior profile image
PCaWarrior

This is the trial:

Study Details | Resistance Training +/- Creatine for Metastatic Prostate Cancer Patients | ClinicalTrials.gov

clinicaltrials.gov/study/NC...

Maxone73 profile image
Maxone73 in reply to PCaWarrior

Hope to read some results soon!

PCaWarrior profile image
PCaWarrior in reply to Maxone73

Primary completion estimated date summer 2024.

London441 profile image
London441

“If your body doesn't make testosterone, you can't build muscle mass”. BS.

Of course you can. It just takes more effort to build less. Creatine’s effects are comparatively insignificant in this context. T suppression gets the blame for all the muscle loss in Pca patients but it’s only one of 4 metrics at work. The others are age, previous deconditioning and ADT induced fatigue feeding on itself.

Going into ADT we are already old. The vast majority of us are not consistently intervening by the time we are diagnosed and begin ADT. Atrophy has been gaining momentum.

These days most men in their 50’s and (especially older) either never lifted regularly or stopped lifting a long time ago. They never tire of talking about how much they used to though. When we are older and don’t lift we lose strength at an accelerating rate.

The good news is that for those who either stopped, cut back significantly or never did lift, their weakness gives them a excellent opportunity to build. Not size, strength. Building muscle size when you’re old is rare. Building strength when older is definitely possible, and the weaker you are the faster and more accessible the gains. Even on ADT.

Creatine…I guess. I prefer effort.

Maxone73 profile image
Maxone73 in reply to London441

And GH

Teufelshunde profile image
Teufelshunde

I look at things differently. Do any of the studies say it promotes PC? If not, and there is some support for a benefit, why not take it? I need to measure my arms now at 66. Most of my contemporaries have scrawny arms and all in the medical community know the direct tie between muscle mass and longevity in general. You will never see a "gold standard" clinical study on this.

Maxone73 profile image
Maxone73 in reply to Teufelshunde

One does but it’s not clinical, and being already metastatic I don’t want to give those bastards any advantage! 😜

j-o-h-n profile image
j-o-h-n

Mouse study? Geez I never knew those little sob's could even read....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 10/13/ 2023 4:02 PM DST -- Ex wife's birthday.

Maxone73 profile image
Maxone73 in reply to j-o-h-n

😂😂😂

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