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Experiences with
Transurethral resection of the prostate (TURP)
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Large Prostate more difficult to remove ?
In 2013 I had robotic prostatectomy. My prostate was quite large, volume 130ml, size 7.43x5.61x5.97cm. As a result, prostate was removed in two pieces, no seminal vesicles where removed and path: "pT2c bilateral, pNx, GL 4+3 Tertiary 5, EPE not identified, SUV not identified". I understand, pNx means
In 2013 I had robotic prostatectomy. My prostate was quite large, volume 130ml, size 7.43x5.61x5.97cm. As a result, prostate was removed in two pieces, no seminal vesicles where removed and path: "pT2c bilateral, pNx, GL 4+3 Tertiary 5, EPE not identified, SUV not identified". I understand, pNx means
Maxi54
in
Advanced Prostate Cancer
2 months ago
Husband getting extremely tired on Zytiga
Tim began Zytiga one month ago. He is also doing Lupron and EBRT which will be over in 5 sessions (he had 5 weeks of them all together). Up until about 5 days ago, he was working and then going to Pilates once a week and to the gym, but now he is coming home EXHAUSTED from work and barely has the energy
Tim began Zytiga one month ago. He is also doing Lupron and EBRT which will be over in 5 sessions (he had 5 weeks of them all together). Up until about 5 days ago, he was working and then going to Pilates once a week and to the gym, but now he is coming home EXHAUSTED from work and barely has the energy
Usernameitis
in
Advanced Prostate Cancer
2 months ago
Has anyone heard of trial DB-1311-O-1001?
Hi all, I’m wondering whether anybody has heard of the above trial? My Dad had been put forward for this and was advised yesterday he got through onto the trial but the paperwork says “first trial on humans”. They aren’t sure of the side effects and we are all feeling a bit apprehensive… My Dad has
Hi all, I’m wondering whether anybody has heard of the above trial? My Dad had been put forward for this and was advised yesterday he got through onto the trial but the paperwork says “first trial on humans”. They aren’t sure of the side effects and we are all feeling a bit apprehensive… My Dad has
Stefciaa
in
Advanced Prostate Cancer
2 months ago
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Finally Something’s Working
I have had this mutherf*cker of a disease 19 years. I have had numerous rounds of Lupron. I have been on Casodex, Erleada, Nubeqa. Zytiga, Provenge, 8 rounds of Docetaxel and, now, Pluvicto. As is standard, after my third round of Pluvicto I had a PSMA PET scan. Finally, something seems to be working
I have had this mutherf*cker of a disease 19 years. I have had numerous rounds of Lupron. I have been on Casodex, Erleada, Nubeqa. Zytiga, Provenge, 8 rounds of Docetaxel and, now, Pluvicto. As is standard, after my third round of Pluvicto I had a PSMA PET scan. Finally, something seems to be working
MJCA
in
Advanced Prostate Cancer
2 months ago
How many treatments of Chemo can the body handle
I have had 7 cycles of docetaxel and 3 of cabazitaxel. The oncologist wants to continue with another 7 cycles of cabazitaxel. My question is how much of this poison can the body handle. Does this chemo destroy things permanently in the body. I know that the fatigue is taking over. I couldn't run
I have had 7 cycles of docetaxel and 3 of cabazitaxel. The oncologist wants to continue with another 7 cycles of cabazitaxel. My question is how much of this poison can the body handle. Does this chemo destroy things permanently in the body. I know that the fatigue is taking over. I couldn't run
Islandboy2021
in
Advanced Prostate Cancer
2 months ago
Kindly seeking advice about my options
I'm metastatic HSPCa on Lupron/Erleada over two years now. Three periaortic lymph nodes and two ribs lesions. Sooner or later, I will go metastatic HRPCa (average about 3 years to become hormone resistant). So, my question is what kind of treatment coming next Thanks for your input
I'm metastatic HSPCa on Lupron/Erleada over two years now. Three periaortic lymph nodes and two ribs lesions. Sooner or later, I will go metastatic HRPCa (average about 3 years to become hormone resistant). So, my question is what kind of treatment coming next Thanks for your input
Maxi54
in
Advanced Prostate Cancer
2 months ago
My Cancer Journey Repost
It's time for a repost of my two-part cancer journey diary. Some "starting the journey readers" might find it helpful. Originally posted as two Health Unlocked "replies" - maybe I should make them an actual full "post". So I am pleased to report that
other than fatigue, I feel sort of normal right
It's time for a repost of my two-part cancer journey diary. Some "starting the journey readers" might find it helpful. Originally posted as two Health Unlocked "replies" - maybe I should make them an actual full "post". So I am pleased to report that
other than fatigue, I feel sort of normal right
JohnInTheMiddle
in
Advanced Prostate Cancer
2 months ago
Phase 1/2 of TLX592 Targeted Alpha Therapy in Prostate Cancer starting soon - Ac 225
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
2 months ago
Chronic sinus issues
I’m currently on an Xtandi, Zometa and Lupron treatment plan. Could there be a correlation between one of these drugs and chronic sinus stuffiness? I also take a cholesterol drug and 3 different blood pressure meds. Thanks in advance if anyone has information. My Best Jim
I’m currently on an Xtandi, Zometa and Lupron treatment plan. Could there be a correlation between one of these drugs and chronic sinus stuffiness? I also take a cholesterol drug and 3 different blood pressure meds. Thanks in advance if anyone has information. My Best Jim
NDJIM
in
Advanced Prostate Cancer
2 months ago
Ped5i/Tadalafil etc as a benefit to SE of ADT?
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
pj1121
in
Advanced Prostate Cancer
2 months ago
Will Existing Drugs Stop Cancer's Bone Spread? I don't know but it's driving me crazy!
Just because I cannot know which are the two repurposed drugs that seem to have such great results with metastasis. The chief researcher is Neta Erez who has great reputation in research about bone metastasis. I am inclined to think about Ivermectin as one of the possible components of the cocktail,
Just because I cannot know which are the two repurposed drugs that seem to have such great results with metastasis. The chief researcher is Neta Erez who has great reputation in research about bone metastasis. I am inclined to think about Ivermectin as one of the possible components of the cocktail,
Maxone73
in
Fight Prostate Cancer
2 months ago
Is Orgovyx as effective as Lupron/Degarelix ?
My Dad , 83 , with bone mets has started bicalutamide since a week and is soon to take the Lupron shot. But he has a fear of injections as many years back he has developed an abscess due to an injection wrongly given. Is orgovyx as effective as the injections in reducing testesterone ? One doctor
My Dad , 83 , with bone mets has started bicalutamide since a week and is soon to take the Lupron shot. But he has a fear of injections as many years back he has developed an abscess due to an injection wrongly given. Is orgovyx as effective as the injections in reducing testesterone ? One doctor
Tinkudi
in
Advanced Prostate Cancer
2 months ago
Lupron - are there heart risks?
My father , 83 , recently got diagnosed with Prostate cancer with mets to some bones , as per PSMA test. We have not done a biopsy as one doctor said there is no need to do it as treatment options won’t change but another doctor says it’s good to do it in case later down the line we need to add treatments
My father , 83 , recently got diagnosed with Prostate cancer with mets to some bones , as per PSMA test. We have not done a biopsy as one doctor said there is no need to do it as treatment options won’t change but another doctor says it’s good to do it in case later down the line we need to add treatments
Tinkudi
in
Advanced Prostate Cancer
2 months ago
Previous c section ivf
hi everyone , I know this is an unusual case . I have had 4 c sections with my naturally conceived children however I am having to go down the ivf route now as initially my husbands sperm count was low however now it isn’t and I’m just not getting pregnant . Our first ivf fresh cycle failed and I’m
hi everyone , I know this is an unusual case . I have had 4 c sections with my naturally conceived children however I am having to go down the ivf route now as initially my husbands sperm count was low however now it isn’t and I’m just not getting pregnant . Our first ivf fresh cycle failed and I’m
Natasha2012
in
Fertility Network UK
7 months ago
Bayer Starts Phase I Study With Novel Targeted Radionuclide Therapy 225Ac-PSMA-Trillium in Advanced Metastatic Prostate Cancer
225Ac-PSMA-Trillium (BAY 3563254) is an investigational next-generation PSMA-targeted alpha therapy with potential to treat patients with advanced metastatic prostate cancer Prostate cancer is the second most commonly diagnosed cancer in men1, with less than three years median survival among metastatic
225Ac-PSMA-Trillium (BAY 3563254) is an investigational next-generation PSMA-targeted alpha therapy with potential to treat patients with advanced metastatic prostate cancer Prostate cancer is the second most commonly diagnosed cancer in men1, with less than three years median survival among metastatic
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
God_Loves_Me
in
Advanced Prostate Cancer
2 months ago
Drugs and high Calcium
My Oncologist wants me to take Prolia, but the Insurance will not pay for it and wants me to take Zometa. However, I did research on Zometa and its reputation is questionable. What are the alternatives? Xgeva seems better. Any thoughts about this.
My Oncologist wants me to take Prolia, but the Insurance will not pay for it and wants me to take Zometa. However, I did research on Zometa and its reputation is questionable. What are the alternatives? Xgeva seems better. Any thoughts about this.
Poollover
in
Advanced Prostate Cancer
2 months ago
Non invasive detection of neuroendocrine PCa
An innovation to detect neuroendocrine PCa...and one of the researchers is a friend so I wanted to promote this paper :-P https://www.urotoday.com/video-lectures/prostate-cancer/video/mediaitem/3995-non-invasive-detection-of-neuroendocrine-prostate-cancer-through-targeted-cell-free-dna-methylation-himisha-beltran-francesca-demichelis.html
An innovation to detect neuroendocrine PCa...and one of the researchers is a friend so I wanted to promote this paper :-P https://www.urotoday.com/video-lectures/prostate-cancer/video/mediaitem/3995-non-invasive-detection-of-neuroendocrine-prostate-cancer-through-targeted-cell-free-dna-methylation-himisha-beltran-francesca-demichelis.html
Maxone73
in
Advanced Prostate Cancer
2 months ago
Positive effect of diet on the whole PCa / APCa spectrum
https://www.urologytimes.com/view/plant-based-diet-demonstrates-benefits-along-spectrum-of-prostate-cancer +lots of exercise
https://www.urologytimes.com/view/plant-based-diet-demonstrates-benefits-along-spectrum-of-prostate-cancer +lots of exercise
Derf4223
in
Advanced Prostate Cancer
2 months ago
In vivo/vitro: Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
2 months ago
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