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ASCO 2023: AI-Derived Digital Pathology Biomarker Predicts Benefit of Long-Term ADT with Radiotherapy in Localized High-Risk Prostate Cancer
https://www.urotoday.com/conference-highlights/asco-2023/asco-2023-prostate-cancer/144902-asco-2023-development-and-validation-of-an-ai-derived-digital-pathology-based-biomarker-to-predict-benefit-of-long-term-androgen-deprivation-therapy-with-radiotherapy-in-men-with-localized-high-risk-prostate-cancer-across-multiple-phase-iii-nrg-rtog-trials.html
https://www.urotoday.com/conference-highlights/asco-2023/asco-2023-prostate-cancer/144902-asco-2023-development-and-validation-of-an-ai-derived-digital-pathology-based-biomarker-to-predict-benefit-of-long-term-androgen-deprivation-therapy-with-radiotherapy-in-men-with-localized-high-risk-prostate-cancer-across-multiple-phase-iii-nrg-rtog-trials.html
zeitgeistxx
in
Advanced Prostate Cancer
7 months ago
Short-term vs Long-Term ADT for High Risk Men
Here's a review of a recent presentation at ASCO 2023 by Artera.ai regarding the use of Artificial Intelligence analysis of biopsy slides to predict which high-risk men do or don't benefit from short-term ADT vs long-term ADT. Their findings are summarized here: [i]"Based on these results, it appears
Here's a review of a recent presentation at ASCO 2023 by Artera.ai regarding the use of Artificial Intelligence analysis of biopsy slides to predict which high-risk men do or don't benefit from short-term ADT vs long-term ADT. Their findings are summarized here: [i]"Based on these results, it appears
janebob99
in
Prostate Cancer Network
7 months ago
Managing OAB after proton RT
Hello everyone, This 73 year old treated an unfavorable intermediate localized PCa with 28 fractions of proton radiation, completed on Dec. 15th. Completed a 4 months course of oral Orgovyx on Dec. 28th. The side effects of the ADT were hot flashes (tolerable) and loss of libido. The side effects
Hello everyone, This 73 year old treated an unfavorable intermediate localized PCa with 28 fractions of proton radiation, completed on Dec. 15th. Completed a 4 months course of oral Orgovyx on Dec. 28th. The side effects of the ADT were hot flashes (tolerable) and loss of libido. The side effects
old_reliable
in
Prostate Cancer Network
7 months ago
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Help and advice please
Hi I just wondered if anyone had any advice that might help me please I have attached my latest NHS blood test results, I am taking NDT thyroid medication called NP. Which at the moment I have started alternating for example one and then one and a half grain every other day. I have seen endocrinologist's
Hi I just wondered if anyone had any advice that might help me please I have attached my latest NHS blood test results, I am taking NDT thyroid medication called NP. Which at the moment I have started alternating for example one and then one and a half grain every other day. I have seen endocrinologist's
Bess48
in
Thyroid UK
7 months ago
Will T return?
As I near the end of my 2 years of ADT (Lupron + Abi), I am curious if I should expect a return of Testosterone. I would love to regain my libido and endurance. But after 2 years, I don't know what to expect. My MO has been pretty vague about what to expect. Another issue is that I didn't have a
As I near the end of my 2 years of ADT (Lupron + Abi), I am curious if I should expect a return of Testosterone. I would love to regain my libido and endurance. But after 2 years, I don't know what to expect. My MO has been pretty vague about what to expect. Another issue is that I didn't have a
jmarsh
in
Advanced Prostate Cancer
7 months ago
PSA 6 months after RT
Here is a review of a presentationby Dr. Ravi at ASCO 2023, regarding measuring the PSA at 6 months post radiation treatment, for all risk groups. He found that the 6-month post-RT PSA was highly prognostic of 5- and 10-year rates of metastasis free survival (MFS), Overall Survival (OS), and prostate
Here is a review of a presentationby Dr. Ravi at ASCO 2023, regarding measuring the PSA at 6 months post radiation treatment, for all risk groups. He found that the 6-month post-RT PSA was highly prognostic of 5- and 10-year rates of metastasis free survival (MFS), Overall Survival (OS), and prostate
janebob99
in
Prostate Cancer Network
7 months ago
In hospital take ndt
Hi. Just a question regarding hospital stays and taking unprescribed ndt. I am probably going to be in hospital soon and am wondering what the heck to do about my thyroid s. I ended up in A&E with chest pains and was put on a ward where they took my antibiotics off me and put them in a locked cupboard
Hi. Just a question regarding hospital stays and taking unprescribed ndt. I am probably going to be in hospital soon and am wondering what the heck to do about my thyroid s. I ended up in A&E with chest pains and was put on a ward where they took my antibiotics off me and put them in a locked cupboard
Catlover3
in
Thyroid UK
7 months ago
Testosterone was nearly back to normal, then dropped
I had a year of Lupron and Enzalutamide in 2022. Testosterone slowly came back to a high of about 240 in June and Sept 2023. Normal for me is around 350 - 375. Now this week T is down to 156. Is this sort of fluctuation normal? I had 6 months of ADT in connection with radiation for recurrent PCa
I had a year of Lupron and Enzalutamide in 2022. Testosterone slowly came back to a high of about 240 in June and Sept 2023. Normal for me is around 350 - 375. Now this week T is down to 156. Is this sort of fluctuation normal? I had 6 months of ADT in connection with radiation for recurrent PCa
Teddy28
in
Advanced Prostate Cancer
7 months ago
Frequency of testing
Hello all,I'm sure this has been answered 100 times, but I'm having difficulty finding the information. My question is how quickly do TSH, T3, and T4 numbers react to a change of medication dose. 8 weeks? 12 weeks? Does TSH react more quickly than T3 and T4? I ask specifically because 6 weeks ago
Hello all,I'm sure this has been answered 100 times, but I'm having difficulty finding the information. My question is how quickly do TSH, T3, and T4 numbers react to a change of medication dose. 8 weeks? 12 weeks? Does TSH react more quickly than T3 and T4? I ask specifically because 6 weeks ago
lutepavan
in
Thyroid UK
7 months ago
BONE DENSITY TEST IS BAD
I am 68 with low volume metastatic to hip bones. Nothing elsewhere, at this time. Had PSA of 125 last April, and oncologist put me on Relogolix and Darolutemide. That along with going to plant based diet and adding weights and HITT exercise 3-4x per week, has brought me down to < .006. that’s the
I am 68 with low volume metastatic to hip bones. Nothing elsewhere, at this time. Had PSA of 125 last April, and oncologist put me on Relogolix and Darolutemide. That along with going to plant based diet and adding weights and HITT exercise 3-4x per week, has brought me down to < .006. that’s the
JL1955
in
Advanced Prostate Cancer
7 months ago
Holding very low stable usPSA - 0.03X range for six years; no ADT, no chemo.
Eight years ago this month had RP after considerable investigation - nadir 0.050. Eleven months later had salvage RT; done at 0.10. Then after a year of pondering ADT and chemo, when my usPSA was back up to 0.10, I went to Europe for Ferrotran nano-MRI combined with Ga68 PSMA. The nanoMRI lite up
Eight years ago this month had RP after considerable investigation - nadir 0.050. Eleven months later had salvage RT; done at 0.10. Then after a year of pondering ADT and chemo, when my usPSA was back up to 0.10, I went to Europe for Ferrotran nano-MRI combined with Ga68 PSMA. The nanoMRI lite up
NanoMRI
in
Advanced Prostate Cancer
7 months ago
Spine metastasis
My father in law is 78 year old male with PCA with what appears to be a single spine metastasis. Gleason 7 ( 4+3) We have an appointment coming up with the radiation oncologist . Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site
My father in law is 78 year old male with PCA with what appears to be a single spine metastasis. Gleason 7 ( 4+3) We have an appointment coming up with the radiation oncologist . Is this something they would get a PSMA TEST for to confirm and also would he just receive ADT with radiation to primary site
Telegraph2022
in
Advanced Prostate Cancer
7 months ago
Full circle with this disease
Diagnosed 2017 PSA 105 started ADT, 6 rounds Docetaxel and radiation PSA drops to undetectable. Castrate resistant 2022 started Abiraterone and prednisone this failed after 3 months. Start Xgeva and Xofigo 2023. PSA back at 105 November 2023. Start 10 rounds of Docetaxel and PSA starts dropping again
Diagnosed 2017 PSA 105 started ADT, 6 rounds Docetaxel and radiation PSA drops to undetectable. Castrate resistant 2022 started Abiraterone and prednisone this failed after 3 months. Start Xgeva and Xofigo 2023. PSA back at 105 November 2023. Start 10 rounds of Docetaxel and PSA starts dropping again
Islandboy2021
in
Advanced Prostate Cancer
7 months ago
T3 and NDT help/advice
I have an Endo appt, 6 February, after a very long delay. I am struggling to function, despite an increase Levo to 125mg. The normal pattern; feel slightly better for a short few weeks then the awful symptoms come crashing back. I cannot function properly. I am trying to find out how to self
I have an Endo appt, 6 February, after a very long delay. I am struggling to function, despite an increase Levo to 125mg. The normal pattern; feel slightly better for a short few weeks then the awful symptoms come crashing back. I cannot function properly. I am trying to find out how to self
sunbee
in
Thyroid UK
7 months ago
Iron study results help please
HiI had a ferritin test in November and posted my results here and got some help. My result then was low at 10.2ug/l I have since persuaded the doctor to do further tests for iron. Unfortunately she did not repeat ferritin but did an iron study results as follows Serum iron level 19 umol/L [9.0 - 30.4
HiI had a ferritin test in November and posted my results here and got some help. My result then was low at 10.2ug/l I have since persuaded the doctor to do further tests for iron. Unfortunately she did not repeat ferritin but did an iron study results as follows Serum iron level 19 umol/L [9.0 - 30.4
Cn13
in
Thyroid UK
7 months ago
Enzalutimide and Amolidipine
Hi back again and you have heard it before but this time something new has been found which l wanted to share Wrote after Xmas re husband being on 160mg as 2nd add on to Adt due to CRPC . 12 Weeks in and Blood Pressure went off the wall, we were given a prescription of 5mg Amolidipine which did nothing
Hi back again and you have heard it before but this time something new has been found which l wanted to share Wrote after Xmas re husband being on 160mg as 2nd add on to Adt due to CRPC . 12 Weeks in and Blood Pressure went off the wall, we were given a prescription of 5mg Amolidipine which did nothing
Knittingque
in
Advanced Prostate Cancer
7 months ago
More Evidence Linking ADT for PCa to Adverse Neurocognitive Effects -Meta-analysis shows increased risk of dementia, Parkinson's, depression
[i]As if we needed more reasons to dislike or avoid ADT, here is additional evidence of negative neurocognitive effects. This MedPage Today article will expecially be of special interest to those of us well into our "Golden Years" and on or considering ADT. [/i]
More Evidence Linking ADT for Prostate
[i]As if we needed more reasons to dislike or avoid ADT, here is additional evidence of negative neurocognitive effects. This MedPage Today article will expecially be of special interest to those of us well into our "Golden Years" and on or considering ADT. [/i]
More Evidence Linking ADT for Prostate
cujoe
in
Fight Prostate Cancer
7 months ago
given a choice about duration of ADT
Tall Allen and others. Clean PSMA, , 3+4, 3+4, and 4+3., biopsy. 77yrs old, hit gym daily but have significant side effects of lupron.. Being treated at Comprensive cancer center. Plan was one year of Lupron. After five SBRT, and nine months on adt, my doc is willing to let me terminate my Lupron
Tall Allen and others. Clean PSMA, , 3+4, 3+4, and 4+3., biopsy. 77yrs old, hit gym daily but have significant side effects of lupron.. Being treated at Comprensive cancer center. Plan was one year of Lupron. After five SBRT, and nine months on adt, my doc is willing to let me terminate my Lupron
Photographerhere
in
Prostate Cancer Network
7 months ago
Working with Stage IV
First time posting (be gentle) Anybody else still at work with the disease. I’ve contributed to a pension for 24 years, and with being diagnosed, am I being foolish staying at work. Note-minimum retirement is 58 at my work. Also, did read this right, ADT only gives about 10 mos. to 1 year increase
First time posting (be gentle) Anybody else still at work with the disease. I’ve contributed to a pension for 24 years, and with being diagnosed, am I being foolish staying at work. Note-minimum retirement is 58 at my work. Also, did read this right, ADT only gives about 10 mos. to 1 year increase
BigJ32
in
Advanced Prostate Cancer
7 months ago
Are Lymph nodes a filter?
Do lymph nodes simply act as a temporary filter to prevent cancer from spreading too far? I was curious about this because I have 4th stage prostate cancer, and my Lymph had swelled to the size of a golfball. When I took the ADT, my PSA went from 1000, down to 6, and all evidence of cancer disappeared
Do lymph nodes simply act as a temporary filter to prevent cancer from spreading too far? I was curious about this because I have 4th stage prostate cancer, and my Lymph had swelled to the size of a golfball. When I took the ADT, my PSA went from 1000, down to 6, and all evidence of cancer disappeared
Aldo62
in
Advanced Prostate Cancer
7 months ago
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