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Phase III Study: Saruparib Combo with New Hormonal Agents in mCSPC +/- HRR Mutations: AUA 2024 EvoPAR-Prostate01 Trial
AUA 2024: EvoPAR-Prostate01: Phase III, Double-Blind, Placebo-Controlled, 2-Cohort, Randomized Study of Saruparib (AZD5305) in Combination with New Hormonal Agents in Patients with mCSPC +/- HRR Mutations (UroToday.com) The 2024 American Urological Association (AUA) annual meeting featured a session
AUA 2024: EvoPAR-Prostate01: Phase III, Double-Blind, Placebo-Controlled, 2-Cohort, Randomized Study of Saruparib (AZD5305) in Combination with New Hormonal Agents in Patients with mCSPC +/- HRR Mutations (UroToday.com) The 2024 American Urological Association (AUA) annual meeting featured a session
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Any guidance appreciated!
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
Hi everyone, My Dad (77) diagnosed in January w/ stage 4 PC, mets to L5 spine. PET scan showed no other spots elsewhere. PSA was 19 at time of diagnosis, Gleason 10. BRCA negative. PSA is now at 0.2 since starting hormone therapy. Feeling good, no pain. Still works (owns his own company). Started
LDC2024
in
Advanced Prostate Cancer
3 months ago
oligometastic
I had a PSMA scan that found 3 small spots. My MO and Radiation O decided to radiate the spots without ADT. PSA is 0.28
I had a PSMA scan that found 3 small spots. My MO and Radiation O decided to radiate the spots without ADT. PSA is 0.28
Howard53545
in
Advanced Prostate Cancer
3 months ago
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TRAP trial: radiotherapy combined with hormone therapy can help some advanced prostate cancer patients avoid chemotherapy
TRAP is maybe not the best name for a clinical trial, but hey… https://www.icr.ac.uk/news-archive/new-trial-finds-radiotherapy-combined-with-hormone-therapy-can-help-some-advanced-prostate-cancer-patients-avoid-chemotherapy
TRAP is maybe not the best name for a clinical trial, but hey… https://www.icr.ac.uk/news-archive/new-trial-finds-radiotherapy-combined-with-hormone-therapy-can-help-some-advanced-prostate-cancer-patients-avoid-chemotherapy
Maxone73
in
Advanced Prostate Cancer
3 months ago
Si Joint/back pain
Hi I have a history of back pain and endometriosis. I recently turned 50 and leading up to my period my si joint pain has suddenly got worse and it all goes into spasms and I literally can't do a lot. It's not great the rest of the month either. I had linked it to the menopause or back issues but
Hi I have a history of back pain and endometriosis. I recently turned 50 and leading up to my period my si joint pain has suddenly got worse and it all goes into spasms and I literally can't do a lot. It's not great the rest of the month either. I had linked it to the menopause or back issues but
AMS_1
in
Endometriosis UK
3 months ago
A-Dream iADT Protocol
It has been awhile since my last post. Short story is I responded well to the doublet therapy in Arasec (lupron+daro). MO believes there is some chance my M1B diagnosis at the start was incorrect (he refers to my case as 'discordant' - due to conflicting data - Gleason 6 but some spots lit up on
It has been awhile since my last post. Short story is I responded well to the doublet therapy in Arasec (lupron+daro). MO believes there is some chance my M1B diagnosis at the start was incorrect (he refers to my case as 'discordant' - due to conflicting data - Gleason 6 but some spots lit up on
Heykm01
in
Advanced Prostate Cancer
3 months ago
GP Coming - what to ask
having my annual review tomorrow and GP is coming to see me. Looking at all my past results I wonder, with them being up and down constantly, whether I am one of those whereby Levo no longer works for me and might be keeping me ill. Diagnosed back in 2005 and it's too far back to remember how I was
having my annual review tomorrow and GP is coming to see me. Looking at all my past results I wonder, with them being up and down constantly, whether I am one of those whereby Levo no longer works for me and might be keeping me ill. Diagnosed back in 2005 and it's too far back to remember how I was
Jefner
in
Thyroid UK
3 months ago
Exercise making it worse?
Hi everyone, I have a question about exercise and endo. So basically I've been pretty much bedbound all of last year with rare weeks of being able to function, but lately I've experience a good couple of months of feeling better and being able to live! (Don't get me wrong still in pain but manageable
Hi everyone, I have a question about exercise and endo. So basically I've been pretty much bedbound all of last year with rare weeks of being able to function, but lately I've experience a good couple of months of feeling better and being able to live! (Don't get me wrong still in pain but manageable
Lavenderpetal
in
Endometriosis UK
7 months ago
Walsh's Folly?
I posted earlier that I had to ask ChatGPt "who came up with the 'gasoline on a fire' characterization regarding the relationship of testosterone and prostate cancer" and that Chat GPT had answered -- Dr. Patrick Walsh -- (father of the radical prostatectomy.) In that post, discussion turned to Walsh's
I posted earlier that I had to ask ChatGPt "who came up with the 'gasoline on a fire' characterization regarding the relationship of testosterone and prostate cancer" and that Chat GPT had answered -- Dr. Patrick Walsh -- (father of the radical prostatectomy.) In that post, discussion turned to Walsh's
VoxHope
in
Advanced Prostate Cancer
3 months ago
Celebrex and Curcumin and Magnesium.
I recently received a question from a fellow warrior based on a comment I had made on an older post that he had started. The question was what I thought about Naproxen compered to Celebrex and I told him I had very limited experience with Naproxen. I then clicked on older posts about nsaids and prostate
I recently received a question from a fellow warrior based on a comment I had made on an older post that he had started. The question was what I thought about Naproxen compered to Celebrex and I told him I had very limited experience with Naproxen. I then clicked on older posts about nsaids and prostate
Professorgary
in
Advanced Prostate Cancer
3 months ago
Would be grateful for your thoughts on my blood results before endo apt please, still feeling exhausted and weak. Thank you
Hello, I’ve had an underactive thyroid for 8 years after having my first child, looks like Hashimotos. Currently taking 100mcg levothyroxine and 15mcg liothyronine (10mcg on waking and 5 around 3pm). Also on HRT patches as am mid 40s and perimenopausal. I’m gluten free, have had SIBO in the past.
Hello, I’ve had an underactive thyroid for 8 years after having my first child, looks like Hashimotos. Currently taking 100mcg levothyroxine and 15mcg liothyronine (10mcg on waking and 5 around 3pm). Also on HRT patches as am mid 40s and perimenopausal. I’m gluten free, have had SIBO in the past.
Hopetoheal22
in
Thyroid UK
3 months ago
"Gasoline" Source
I have been trying to find the source for the observation? that "Testosterone to prostate cancer is like gasoline on a fire". I finally asked Bing Copilot and ChatGPT-- who came up with the answer. Me: What is the source of the "gasoline on a fire" theory in prostate cancer? ChatGPT: Dr. Patrick
I have been trying to find the source for the observation? that "Testosterone to prostate cancer is like gasoline on a fire". I finally asked Bing Copilot and ChatGPT-- who came up with the answer. Me: What is the source of the "gasoline on a fire" theory in prostate cancer? ChatGPT: Dr. Patrick
VoxHope
in
Advanced Prostate Cancer
3 months ago
What comes after, what comes next?
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
I have posted a few times about my dad. Stage 4, mets to 8+ bones at time of diagnosis, PSA at 137 (10/22.) Lupron twice a year, Bicalutamide, failed at 7 months, Xtandi failed at 4 months, currently on Zytiga. We met with my dad’s oncologist on 4/24. My Dad’s PSA dropped from 2.47-1.46 and pain has
lgutman
in
Advanced Prostate Cancer
3 months ago
hrt increase
Hi l recently increased my hrt patch from 50 to 75 and am experiencing body aches and prickly skin sensations. Is this normal? Also quite emotional too.
Hi l recently increased my hrt patch from 50 to 75 and am experiencing body aches and prickly skin sensations. Is this normal? Also quite emotional too.
RayannAbbey
in
Anxiety and Depression Support
3 months ago
ADT + Docetaxel
Am mCRPC and will be starting Docetaxel soon, after apparent failure of Zytiga. Would like to know if I should continue the ADT (zoladex), which I have tolerated well for 3 years. Most trial info I have found (STAMPEDE, CHAARTED) tests ADT alone vs ADT + Docetaxel, where the combination outcome is
Am mCRPC and will be starting Docetaxel soon, after apparent failure of Zytiga. Would like to know if I should continue the ADT (zoladex), which I have tolerated well for 3 years. Most trial info I have found (STAMPEDE, CHAARTED) tests ADT alone vs ADT + Docetaxel, where the combination outcome is
Ian99
in
Advanced Prostate Cancer
3 months ago
ADT & Pluvicto
Is it common to continue ADT treatments, like Lupron or Eligard, while receiving Pluvicto therapy?
Is it common to continue ADT treatments, like Lupron or Eligard, while receiving Pluvicto therapy?
Shams_Vjean
in
Advanced Prostate Cancer
3 months ago
Why is this so hard, someone to talk to
Hi everyone. I had treatment resistant depression for my entire adult life, I've been on pretty much every med, hospitalized, ECT tms and ketamine. Nothings helped. I've gone the DBT and cbt route. I've been suicidal. Can anyone out there relate? I'm married with a 13 year old which makes it harder.
Hi everyone. I had treatment resistant depression for my entire adult life, I've been on pretty much every med, hospitalized, ECT tms and ketamine. Nothings helped. I've gone the DBT and cbt route. I've been suicidal. Can anyone out there relate? I'm married with a 13 year old which makes it harder.
Coffeeshop
in
Anxiety and Depression Support
7 months ago
Salvage options?
Hello again, I have a few more questions, to help my husband decide between surgery and brachyboost. For context, he is localized Gleason 9. (1) Is the course of salvage radiation after RP typically the same as it would have been if the initial treatment had been radiation therapy? Or would it require
Hello again, I have a few more questions, to help my husband decide between surgery and brachyboost. For context, he is localized Gleason 9. (1) Is the course of salvage radiation after RP typically the same as it would have been if the initial treatment had been radiation therapy? Or would it require
EvFC
in
Advanced Prostate Cancer
4 months ago
If you are thinking of Travel - Go For It.
Hello everyone, We're midway through our 10-week holiday adventure, and it's been quite a journey so far! From Japan to Finland, Turkey, and now Italy, we've covered quite a bit of ground. Traveling alongside another couple, our time in Turkey stands out, where I took on the role of designated driver
Hello everyone, We're midway through our 10-week holiday adventure, and it's been quite a journey so far! From Japan to Finland, Turkey, and now Italy, we've covered quite a bit of ground. Traveling alongside another couple, our time in Turkey stands out, where I took on the role of designated driver
Mike58
in
Prostate Cancer Network
4 months ago
Update after GP call
Had my call with the GP that I mentioned in my last posts. That was a bit of a disaster, although not as bad as it could have been. She did not read my notes or blood test results before the call. She asked me about symptoms, but was only concerned about weight gain and dry skin. I had already gone
Had my call with the GP that I mentioned in my last posts. That was a bit of a disaster, although not as bad as it could have been. She did not read my notes or blood test results before the call. She asked me about symptoms, but was only concerned about weight gain and dry skin. I had already gone
Heappestre
in
Thyroid UK
4 months ago
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